The Zebrafish: Disease Models and Chemical Screens: Volume 138

The Zebrafish: Disease Models and Chemical Screens: Volume 138

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The Zebrafish: Disease Models and Chemical Screens, Fourth Edition, the latest volume in the Methods in Cell Biology series, looks at methods for analyzing genetics, genomics, and transcriptomics of zebrafish. Chapters cover such topics as gene-trap mutagenesis, genetic screens for mutations, gene editing in zebrafish, homologous gene targeting, genome-wide RNA tomography, developmental epigenetics, and the zebrafish interactome. * Covers sections on model systems and functional studies, imaging-based approaches, and emerging studies* Includes chapters written by experts in the field* Contains cutting-edge material on the topics discussed
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Product details

  • Hardback | 746 pages
  • 191 x 235 x 39.62mm | 1,700g
  • Academic Press Inc
  • San Diego, United States
  • English
  • 4th edition
  • 0128034734
  • 9780128034736

Table of contents

Part I: Adipose Tissue 1. In vivo imaging and quantification of regional adiposity in zebrafish

Part II: Innate and Adaptive Immune Systems 2. Innate immune cells and bacterial infection in zebrafish 3. Best practices for germ-free derivation and gnotobiotic zebrafish husbandry 4. Infectious disease models in zebrafish 5. Live imaging the earliest host innate immune response to preneoplastic cells using a zebrafish inducible KalTA4-ERT2/UAS system 6. Studying the adaptive immune system in zebrafish by transplantation of hematopoietic precursor cells

Part III: Blood and Lymph 7. Hematopoietic stem cell development: Using the zebrafish to identify extrinsic and intrinsic mechanisms regulating hematopoiesis 8. Studying disorders of vertebrate iron and heme metabolism using zebrafish 9. The lymphatic vasculature revisited-new developments in the zebrafish

Part IV: Visceral Organs 10. Modeling intestinal disorders using zebrafish 11. Analysis of pancreatic disease in zebrafish

Part V: Musculoskeletal System 12. Using the zebrafish to understand tendon development and repair 13. Small teleost fish provide new insights into human skeletal diseases 14. Muscular dystrophy modeling in zebrafish

Part VI: Central and Sensory Nervous Systems 15. Analysis of myelinated axon formation in zebrafish 16. Zebrafish models of human eye and inner ear diseases

Part VII: Cancer 17. A zebrafish xenograft model for studying human cancer stem cells in distant metastasis and therapy response 18. Zebrafish as a model for von Hippel Lindau and hypoxia-inducible factor signaling 19. Discovering novel oncogenic pathways and new therapies using zebrafish models of sarcoma 20. Zebrafish models of leukemia 21. Investigating microglia-brain tumor cell interactions in vivo in the larval zebrafish brain

Part VIII: Transplantation 22. Transplantation in zebrafish

Part IX: Chemical Screening 23. Chemical screening in zebrafish for novel biological and therapeutic discovery
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Review Text

Praise for the Series:
"The series is invaluable for workers at all levels of cell biology." --Nature
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Review quote

Praise for the Series: "The series is invaluable for workers at all levels of cell biology." --Nature
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About H William Detrich

Professor of Biochemistry and Marine Biology at Northeastern University, promoted 1996. Joined Northeastern faculty in 1987. Previously a faculty member in Dept. of Biochemistry at the University of Mississippi Medical Center, 1983-1987.Principal Investigator in the U.S. Antarctic Program since 1984. Twelve field seasons "on the ice" since 1981. Research conducted at Palmer Station, Antarctica, and McMurdo Station, Antarctica.Research areas: Biochemical, cellular, and physiological adaptation to low and high temperatures. Structure and function of cytoplasmic microtubules and microtubule-dependent motors from cold-adapted Antarctic fishes. Regulation of tubulin and globin gene expression in zebrafish and Antarctic fishes. Role of microtubules in morphogenesis of the zebrafish embryo. Developmental hemapoiesis in zebrafish and Antarctic fishes. UV-induced DNA damage and repair in Antarctic marine organisms. Grousbeck Professor of Pediatrics, Boston Children's Hospital / HHMI, Boston, MA, USA Professor, Department of Biology, Institute of Neuroscience, University of Oregon, Eugene, OR, USA
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