Xenobiotics and Inflammation : Roles of Cytokines and Growth Factors
The effect of xenobiotics on host resistance in general and specific immune functions has become the focus of much current research. This book synthesizes current information on how chemicals (xenobiotics) can affect the immune system to cause dysfunction, focusing on the process of inflammation. Emphasis is placed on the roles of cytokines and growth factors in the inflammatory process and how such processes are altered and modulated by xenobiotics. This volume is pertinent to those exploring the mechanisms responsible for altered host resistance following exposure to xenobiotics. More generally, it is relevant to researchers of cell growth, angiogenesis, haematopoetic differentiation, and recruitment to and proliferation of cells in various tissue sites.
- Hardback | 358 pages
- 152.4 x 228.6 x 20.32mm | 680.39g
- 01 Jul 1994
- Elsevier Science Publishing Co Inc
- Academic Press Inc
- San Diego, United States
Table of contents
Foreword, M. Karol; Immunotoxicity and Inflammation - An Overview, Rosenthal and Luster; The Inflammatory Process, Kovacs and Frazier-Jessen; Inflammatory Cytokines, Brandes and Wahl; Induction of Inflammation: Cytokines and Acute Phase Proteins, Richards and Gauldie; Role of Tumour Necrosis Factor-alpha in Acute and Chronic Inflammatory Responses: Novel Therapeutic Approaches, Edwards, Borcherding, Zhang, and Borcherding; Bone Marrow Phagocytes, Inflammatory Medicators and Benzene Toxicity, MacEachern and Laskin; Nitrosamine-induced Inflammation: Induction of Cytokines Affecting Macrophage Differentiation and Function; The Effects of Metals on Immune System Development and Function, McCabe and Lawrence; Xenobiotic-induced Skin Inflammation, Laskin, Heck, and Ford; The Pathogenesis of Atherosclerosis: A Cytokine Hypothesis, Ku and Jackson; Ozone-induced Inflammatory Response in Pulmonary Cells, Koren, Devlin, and Becker; Pulmonary Fibrosis Induced by Bleomycin and Fibers, Piguet; Role of Inflammatory Mediators and Cytokines in Endotoxin-induced Hepatotoxicity, Laskin; CNS:Viral Infection and Immune-Mediated Inflammation, Schuller-Levis, Kozlowski, and Kascsak; Subject Index.