Xenobiotics and Cancer

Xenobiotics and Cancer : Implications for Chemical Carcinogenesis and Cancer Chemotherapy - International Symposium Proceedings

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The 21st International Symposium of the Princess Takamatsu Cancer Research Fund, covered recent advances in chemical carcinogenesis and cancer chemotherapy. The two areas of xenobiotics and cancer were merged to encourage scientists with diverse interests, to focus their attention on the one theme - a better control of cancer. "Recent developments in cancer research have revealed that there are divergent causes of the multiple genetic alterations found in human cancers. The presence of many potential carcinogens in the everyday environment is represented by newly identified carcinogens in cooked food. Carcinogens are one class of xenobiotics to which human beings are continuously exposed; therefore, not only the amount of carcinogenic xenobiotics but also human response to those xenobiotics are important determinants of human carcinogenesis. Better primary cancer prevention and better cures for this disease thus depend strongly on a deeper understanding of biological responses to xenobiotics".show more

Product details

  • Hardback | 386 pages
  • 203.2 x 254 x 50.8mm | 453.59g
  • Taylor & Francis Ltd
  • London, United Kingdom
  • English
  • 0748400370
  • 9780748400379

Table of contents

Part 1 Bioactivation of xenobiotics: cytochrome P-450s as toxicogenic catalysts - the influence of dehydroepiandrosterone; polymorphic acctylation of arylamines and DNA-adduct formation. Part 2 Xenobiotics and gene regulation: structure-function aspects of the glucocorticoid receptor; molecular genetics of the human glutathione S-transferase. Part 3 Drug resistance: multidrug resistance - a transport system of antitumour agents and xenobiotics. Part 4 Xenobiotics as a cause of human cancer: heterocyclic amines produced in cooked food - unavoidable xenobiotics; natural chemicals, synthetic chemicals, risk assessment, and cancer. Part 5 Biomonitoring: the role of molecular epidemiology in cancer prevention.show more