WTEC Panel Report on Tissue Engineering Research

WTEC Panel Report on Tissue Engineering Research

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WTEC Panel on Tissue Engineering Research is a comparative review of tissue engineering research and development activities in the United States, Japan, and Western Europe conducted by a panel of leading U.S. experts in the field. This book covers biomaterials, cells, biomolecules, non-medical applications, engineering design, informatics, and legal and regulatory issues associated with tissue engineering research and applications.
This document will serve as a basis for continued dialogue within nations' tissue engineering research and development community and with other important stakeholders, providing guidance for future programs. This text highlights the necessity for providing continued and enhanced resources to further the progress in tissue engineering, harness developments, and maintain scientific and economic leadership.
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Product details

  • Hardback | 268 pages
  • 152.4 x 233.7 x 20.3mm | 476.28g
  • Academic Press Inc
  • San Diego, United States
  • English
  • New
  • 0124841503
  • 9780124841505

Table of contents


List of Figures

List of Tables

Executive Summary

1. Introduction

Background: The Significance of Tissue Engineering

History of Tissue Engineering

Promise of Tissue Engineering

Other Applications

Emerging Industry of Tissue Engineering

Objectives of the WTEC Study

Scope and Methodology

Vision for the Future



2 Biomaterials


U.S. R&D Activities

Japanese R&D Activities

European R&D Activities



3 Cells


Analysis of Current State of the Art and Factors Influencing Progress

Control of Cell Proliferation and Differentiation

U.S. R&D Activities


Current Efforts

Future Position

R&D Activities in Europe




4 Biomolecules


Gene Transfer

Angiogenic Factors/Growth Factors

Differentiation Factors

Bone Morphogenic Proteins


5 Cell-Based Technologies: Non-Medical Applications


Overview of R&D Activities


6 Engineering Design Aspects of Tissue Engineering


Bioreactor Technology

Preservation of Cells and Engineered Tissues

Mass Transport Issues Following Implantation

Biomechanics Issues



7 Informatics and Tissue Engineering


Informatics Components That Will Ultimately Support Tissue Engineering

U.S. R&D Activities

European R&D Activities

Japanese R&D Activities



8 Legal and Regulatory Issues


FDA Regulation

Other Considerations Relevant to Engineered Tissues

Regulation of Pharmaceutical/Medical Human Tissue Products in Europe

Regulation of Pharmaceutical/Medical Human Tissue Products in Japan




A. Biographies of Panelists

B. Site Reports-Europe

bwA, Aachen Centre of Competence: Biomaterials

Cell Lining GmbH

Berlin Workshop

ERA Consulting (UK), Ltd

ETH Zurich

European Agency for the Evaluation of Medicinal Products (EMEA)

European Molecular Biology Laboratory (EMBL)

German Cancer Research Center (DKFZ)

German Heart Institute

Humboldt University of Berlin, Charite

Biomaterial and Tissue Repair Laboratory (INSERM)

Imperial College of Science, Technology and Medicine

Imperial College of Science, Technology and Medicine

University of Glasgow

IsoTis (Technical Report)

IsoTis (Regulatory Report)

Kirchhoff Institute of Physics (KIP)

Manchester University

Max Planck Institute for Polymer Research


Smith & Nephew Group Research Centre

University of Freiburg

University of Koln

University of Regensburg

University of Twente

C. Appendix C. Site Reports-Japan

Hokkaido University

Japan Tissue Engineering Company, Ltd

Keio University

Kyoto University

Kyushu University

Nippon Telegraph and Telephone Corporation (NTT) Basic Research Laboratories

Nagoya University

National Cancer Center Research Institute

National Institute for Advanced Interdisciplinary Research (NAIR)

National Institute of Bioscience and Human Technology

Institute of Physical and Chemical Research (RIKEN) Cell Bank

Tokyo Institute of Technology

Tokyo Women's Medical University

University of Tokyo

University of Tsukuba

D. Summary of the June 2000 U.S. Review Workshop

E. The Federal Investment in Tissue Engineering
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About Larry V. McIntire

By Larry V. McIntire
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