This comprehensive and authoritative reference covers all aspects of Vitamin D biology, chemistry, and pharmacology. The book discusses current research on Vitamin D under various pathophysiological conditions and predicts developing uses and areas of study. No other single source currently available deals with the entire subject of Vitamin D. The editors are world-recognized experts, and the authors are carefully chosen authorities on specific topics.
- Hardback | 1200 pages
- 224.5 x 286 x 56.6mm | 4,319.56g
- 01 Oct 1997
- Elsevier Science Publishing Co Inc
- Academic Press Inc
- San Diego, United States
- b&w illustrations, index
Overall the book provides a comprehensive introduction to vitamin D. It will be especially useful for clinical investigators who would like a review of the metabolism of vitamin D so that they can keep abreast of rapid new developments and for basic scientists who are entering the field. --NEW ENGLAND JOURNAL OF MEDICINE
Table of contents
Chemistry and metabolism: Overview, H. Deluca; Vitamin D metabolism, R. Horst, T. Reinhardt; Photobiology of vitamin D, M. Holick; Vitamin D-25 hydroxylase, M. Gascon-Barre; I-hydroxylase, H. Henry; 24-hydroxylase, J. Omdahl, B. May; Vitamin D binding protein, N. Cooke, J. Haddad. Mechanism of action: Vitamin D receptor - the protein and its gene, J.W. Pike; Structural and functional determinants of DNA-binding and dimerization by the vitamin D receptor, L. Freedman, B. Lemon; The nuclear vitamin D receptor - structure/function, phosphorylation and control of gene transcription, M. Haussler et al; Regulation of vitamin D receptor abundance, A. Krishnan, D. Fieldman; Vitamin regulation of type I collagen expression, B. Kream et al; Target genes - bone proteins (OC, OP, MGP), P. Price; Target genes - calbindins, S. Christakos et al; Rapid responses of I(,25(OH)2D3, A. Norman. Target organs and actions: Intestinal calcium and phosphorus absorption, R.H. Wasseman, C. Fullmer; Vitamin D and the kidney, R. Kumar; Vitamin D and bone development, R. St-Amound, F. Glorieux; Vitamin D metabolites and bone, Y. Seino; Bone osteoblasts, J. Aubin, J. Heersche; Vitamin D and osteoclasts, T. Suda, N. Takahashi; Calcitriol interactions with local factors in bone remodelling, P. Stem; Vitamin D and the parathyroid, J. Silver, T. Naveh-Many; Thyroidal C-cells and medullary thyroid carcinoma as target tissues for vitamin D action, R. Gagel, S. Peleg; Vitamin D and the skin, D. Bikle; Cartilage, B. Boyan et al; Vitamin D action on oro-facial development and biomineralization, A. Berdal; Vitamin D in pregnancy, the fetal-placental unit and lactation, A. care; immunomodulatory and cell differentiation effects of vitamin D, J. O'Riordan, M. Hewison; Other vitamin D target tissues, M. Walters. Physiology: Vitamin D - role in the calcium economy, R.P. Heany; Regulation of phosphate transport, K. Hruska, J.-P. Bonjour; Racial, geographic, genetic, and body habitus effects on vitamin D metabolism, D. Mitra, N. Bell; Perinatal vitamin D actions, N. Bishop, B. Salle; Vitamin D and aging, B. Halloran. Diagnosis and management: Radiology of rickets and osteomalacia, J. Adams; Bone histomorphometry, J. Campston; Detection of vitamin D and its major metabolites, B. Hallis; Pharmacology of vitamin D preparations, N. Breslau, J. Zerwekh; Approach to the patient with metabolic bone disease, M. Whyte. Disorders of the vitamin D endocrine system: Vitamin D and the pathogenesis of rickets and osteomalacia, M. Parfitt. (Part contents).