Viral Vectors

Viral Vectors : Gene Therapy and Neuroscience Applications

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Genetic manipulation of the adult mammalian nervous system is one of the most exciting areas in contemporary neurobiology. The explosive growth of this field has been facilitated by harnessing the power of viruses to transfer genetic material into mammalian cells. Viral Vectors: Gene Therapy and Neuroscience Applications represents the first comprehensive review of viral vector applications to the nervous system by leaders in virology, molecular neurobiology, neuroanatomy, and developmental neurobiology. It serves both as a source of fundamental information for those newly interested in viral vectors and as a compilation of state-of-the-art technologies and applications for more experienced researchers. This work provides expert background information on viral systems, and the broad range of applications will help readers appreciate the current and future impact of viral vectors in both clinical and basic neuroscience.
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Product details

  • Paperback | 486 pages
  • 203 x 248 x 26mm | 1,139g
  • Academic Press Inc
  • San Diego, United States
  • English
  • illustrations, index
  • 0123975719
  • 9780123975713

Table of contents

J.C. Glorioso, M.A. Bender, W. F Goins, D.J. Fink, and N. DeLuca, Herpes Simplex Virus as a Gene Delivery Vector for the Central Nervous System. A.D. Kwong and N. Frankel, Biology of Herpes Simplex Virus (HSV) Defective Viruses and Development of the Amplicon System. T Shenk Group C Adenoviruses as Vectors for Gene Therapy. J.S. Bartlett and R.J. Samulski, Genetics and Biology of Adeno-Associated Virus. R. Bannerji, Genetics and Biology of Retroviral Vectors. M.J. During, HSV Vectors in the Mammalian Brain: Molecular Analysis of Neuronal Physiology, Generation of Genetic Models, and Gene Therapy of Neurological Disorders. H.J. Federoff, The Use of Defective Herpes Simplex Virus Amplicon Vectors to Modify Neural Cells and the Nervous System. J. Verhaagen, W.T.J.M.C. Hermens, A.J.G.D. Holmaat, A.B. Oestreicher, and M. G. Kaplitt, Viral Vector-Mediated Gene Transfer in the Nervous System: Application to the Reconstruction of Neural Circuits in the Injured Mammalian Brain. D. Y Hol M.S. Lawrence, TJ. Meier, S.L Fink, and R. Dash, The Use of Herpes Simplex Virus Vectors for Protection from Necrotic Neuron Death. J. Yin, M. G. Kaplitt, and D. W. Pfaff, In Vivo Promoter Analysis in the Adult Central Nervous System Using Viral Vectors. B.L. Davidson and B.J. Roessler, Adenoviral Mediated Gene Transfer: Potential Therapeutic Applications. M. G. Kaplitt and M.J. During, Transfer and Expression of Potentially Therapeutic Genes into the Mammalian Central Nervous System in Vivo Using Adeno-Associated Viral Vectors. U.J. Kang, Genetic Modification of Cells with Retrovirus Vector for Grafting into the Central Nervous System. M.X. Wei, T Tamiya, X.O. Breakefield and E.A. Chiocca, Virus Vector-Mediated Transfer of Drug-Sensitivity Genes for Experimental BrainTumour Therapy. W. Hunter, S. Rabkin, and R. Martuza, Brain Tumour Therapy Using Genetically Engineered Replication-Competent Virus. M.R. Rosenfeld, J.J. Vershuuren, and J. Dalmau, Transfer and Expression of Antioncogenes and Paraneoplastic Genes in Normal and Neoplastic Cells in Vitro and in Vivo. G. Ugolini, Transneuronal Tracing with Alphaherpesviruses: A Review of the Methodology. J.P Card, Pseudorabies Virus Replication and Assembly in the Rodent Central Nervous System. A.D. Loewy, Pseudorabies Virus: A Transneuronal Tracer for Neuroanatomical Studies. T C. Mettenleiter, Molecular Properties of Alphaherpesviruses Used in Transneuronal Pathway Tracing. P. Coulon and A. Flamand, Molecular Analysis of Rabies and Pseudorabies Neurotropism. K. W. McDermott and M.B. Luskin, The Use of Retroviral Vectors in the Study of Cell Lineage and Migration during the Development of the Mammalian Central Nervous System. E.J. Snyder, Retroviral Vectors for the Study of Neuroembryology: Immortalisation of Neural Cells. References. Index.
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