Vascular Innervation and Receptor Mechanisms : New Perspectives
During the past decade our understanding of the complicity of mechanisms controlling circulation has increased. This work provides an overview of vascular innervation and receptor mechanisms, especially the involvement of neurotransmithers, endothelium, and physiological control by neuropeptides. Also examined is the role of neuropeptides. Also examined is the role of neuropeptidergic innervation in vascular disorders and new approaches to possible future therapeutics.
- Hardback | 464 pages
- 158.75 x 230 x 19.05mm | 805g
- 01 Jun 1993
- Elsevier Science Publishing Co Inc
- Academic Press Inc
- San Diego, United States
- references, index
Table of contents
Introduction, G. Burnstock. Basic studies - regulation of the autonomic innervation fo blood vessels during development and ageing, T. Cowen; endothelial-derived relaxing factors - focus on nitric oxide, S.M. Gardiner and T. Bennett; effect of endothelin on circulation system, T. Masaki; interaction between endothelium-derived vasoactive factors and neurohumoral substances in the regulation of vascular tone, G.M. Rubanyi; modulation of endothelial-inflammatory cell interactions by primary afferent nerves, Z. Khalil, et al; the sympathetic system - noradrenaline and neuropeptide Y in the sympathetic system - prejunctional interactions and regulation of release, P. Linton-Dahlof and C. Dahlof; neuropeptide Y (NYP) receptor subtypes, and putative receptor ligands, T. Hedner, et al; ATP as a cotransmitter with noradrenaline in sympathetic perivascular nerves, C. Kennedy; parasympathetic innervation of circulation - regulatory peptides of the parasympathetic vascular innervation, R. Uddman, et al; pharmacology of acetylchlorine and vasoactive intestinal peptide in perivascular nerves, O. Rorstad, et al; sensory afferent system - pattern of innervation of sensory afferent systems in the circulation - immunocytochemistry and ultrastructure, S. Gulbenkian and J. Wharton; calcitonin gene-related peptide and blood vessels, I. Jansen, et al; characterization of neurokinin receptors in the circulation, D. Regoli, et al; peptidergic sensory neurons in the local regulation of splanchnic blood flow, P. Holzer; clinical application - neuropeptides in human cardiovascular regulation, J. Pernow; perivascular peptides (NPY, CGRP, and SP) in hypertension and congestive heart failure, L. Edvinsson, et al; perivascular peptides in the coronary circulation - relation to pathophysiology, J. Clarke; perivascular peptides in subarachnoid hemorrhage, R. Juul and L. Edvinsson; vasoactive peptides in migraine and cluster headache, P.J. Goadsby; perivascular peptides in the respiratory tract, J.G. Widdicombe; gastrointestinal circulation in man and animals - regulation by perivascular peptides and classical neurotransmitters, O. Lundgren.