United States Naval Medical Bulletin Volume 6

United States Naval Medical Bulletin Volume 6

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This historic book may have numerous typos and missing text. Purchasers can download a free scanned copy of the original book (without typos) from the publisher. Not indexed. Not illustrated. 1912 edition. Excerpt: ...typical "lepra cells" of Virchow, or the bacilli attack the plasma cells, destroy their cytoplasm, and so damage the nucleus that it becomes achromatic and breaks into pieces, which remain surrounded by or on one side of a mass of bacilli embedded in mucus, thus giving rise to a false appearance of a giant cell (Unna's theory). The lesions show these large cells--the "lepra cells" containing large masses of bacilli--but, in addition to these cells, there are also masses of bacilli embedded in mucus and not inclosed in cells. The bacilli do not invade the surface epithelium nor the layer of the cutis immediately below this. The typical leproma, therefore, shows, superficially, normal epithelium, with the exception that there are few or no interpapillary processes. Below the epithelium there is a layer of connective tissue free from bacilli, under which lies the typical lesion, composed of lepra cells, plasma cells, connective tissue cells, and, according to some observers, a few polymorphonuclear leukocytes, separated by a very slight amount of fibrillar connective tissue and containing vessels whose walls are thickened by an infiltration of all the coats to such an extent that at times the lumen may be obliterated, while the lymphatic spaces are dilated and filled with bacilli. The bacilli also may enter into the nerves and cause a hyperplasia of the connective tissue cells of the coats and the formation of typical leproma cells at first around the vasa nervorum, and later in the perineurium and endoneurium. These cells press on the nerve fibers, causing a degeneration of the neurilemma and later a disintegration of the arteries and destruction of the nerve fibers. It is usually considered that the peripheral nerves only are...
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Product details

  • Paperback | 272 pages
  • 189 x 246 x 14mm | 490g
  • Miami Fl, United States
  • English
  • black & white illustrations
  • 1236496183
  • 9781236496188