Translational Pain Research

Translational Pain Research : From Mouse to Man

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Description

One of the Most Rapidly Advancing Fields in Modern Neuroscience


The success of molecular biology and the new tools derived from molecular genetics have revolutionized pain research and its translation to therapeutic effectiveness. Bringing together recent advances in modern neuroscience regarding genetic studies in mice and humans and the practicality of clinical trials, Translational Pain Research: From Mouse to Man effectively bridges the gap between basic research and patient care by humanely examining rodent models for pain associated with bone cancer, osteoarthritis, fibromyalgia, and cardiac episodes.





Distinguished Team of International Contributors


In addition to addressing the groundbreaking technical advances in tract tracing, endocannabinoids, cannabis, gene therapy, siRNA gene studies, and the role of glia, cytokines, P2X receptors and ATP, this book also presents cutting-edge information on:











Nociceptor sensitization
Muscle nociceptors and metabolite detection
Visceral afferents in disease
Innovative rodent model for bone cancer pain
Highly specific receptor cloning
Modular molecular mechanisms relevant to painful neuropathies








This sharply focused work also discusses unexpected discoveries derived from brain-imaging studies related to thalamic pain. Translational Pain Research covers the progress made toward bringing laboratory science (much of it at the molecular level) to our understanding of pain phenomena in humans, with the ultimate goal of reducing the suffering that often accompanies pain and its indirect consequences.
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Product details

  • Hardback | 456 pages
  • 160 x 236 x 28mm | 762.03g
  • CRC Press Inc
  • Bosa Roca, United States
  • English
  • Color insert - est 10 figures / # pages TBD; 13 Tables, black and white; 10 Illustrations, color; 66 Illustrations, black and white
  • 1439812098
  • 9781439812099

Table of contents

Painful Multi-Symptom Disorders: A Systems Perspective


C. Richard Chapman





Neurotrophic Factors and Nociceptor Sensitization


Michael P. Jankowski and H. Richard Koerber





The Role of Visceral Afferents in Disease


Julie A. Christianson and Brian M. Davis





Cancer Pain: From the Development of Mouse Models to Human Clinical Trials


Juan Miguel Jimenez Andrade and Patrick Mantyh





Therapeutic Targeting of Peripheral Cannabinoid Receptors in Inflammatory and Neuropathic Pain States


Igor Spigelman





Molecular Strategies for Therapeutic Targeting of Primary Sensory Neurons in Chronic Pain Syndromes


Ichiro Nishimura, Devang Thakor, Audrey Lin, Supanigar Ruangsri, and Igor Spigelman





Transgenic Mouse Models for the Tracing of "Pain" Pathways


Allan I. Basbaum and Joao M. Braz





Cytokines in Pain


Veronica I. Shubayev, Kinshi Kato, and Robert R. Myers





Glial Modulation in Pain States: Translation into Humans


Ryan J. Horvath, Edgar Alfonso Romero-Sandoval, and Joyce A. De Leo





On the Role of ATP-Gated P2X Receptors in Acute, Inflammatory, and Neuropathic Pain


Estelle Toulme, Makoto Tsuda, Baljit S. Khakh, and Kazuhide Inoue





Myalgia and Fatigue: Translation from Mouse Sensory Neurons to Fibromyalgia and Chronic Fatigue Syndromes


Alan R. Light, Charles J. Vierck, and Kathleen C. Light





Reflex Autonomic Responses Evoked by Group III and IV Muscle Afferents


Jennifer L. McCord and Marc P. Kaufman





Central Pain as a Thalamocortical Dysrhythmia: A Thalamic Efference Disconnection?


Kerry D. Walton and Rodolfo R. Llinas





What Can Neuroimaging Tell Us about Central Pain?


D.S. Veldhuijzen, F.A. Lenz, S.C. LaGraize, and J.D. Greenspan





Human Brain Imaging Studies of Chronic Pain: Translational Opportunities


A. Vania Apkarian





Consideration of Pharmacokinetic Pharmacodynamic Relationships in the Discovery of New Pain Drugs


Garth T. Whiteside and Jeffrey D. Kennedy





Large Animal Models for Pain Therapeutic Development


Darrell A. Henze and Mark O. Urban





Drug Discovery and Development for Pain


Sandra R. Chaplan, William A. Eckert III, and Nicholas I. Carruthers





Index
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Review quote

As the editors of Translational Pain Research: From Mouse to Man state in their preface, "the study of pain is of enormous human importance for the obvious reason that in the course of a lifetime, few individuals manage to evade disruption of their lives by consequential pain experiences." The book is a comprehensive survey of recent pain research that attempts to bring basic science closer to the bedside. The primary intended audience of the book is academic and pharmaceutical industry researchers. Laboratory animal veterinarians and research technicians will also find it a useful reference...In conclusion, Translational Pain Research is a comprehensive review of current research in an area of vital interest to laboratory animal professionals responsible for programs in experimental pain research. The book is highly technical but a non-specialist would find it difficult, but ultimately rewarding.
--Journal of the American Association for Laboratory Animal Science, September 2010
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About Lawrence Kruger

Lawrence Kruger, Distinguished Professor of Neurobiology, University of California, USA


Alan Light, Research Professor of Anesthesiology, University of Utah, USA
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