Translational Pain Research

Translational Pain Research

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One of the Most Rapidly Advancing Fields in Modern Neuroscience The success of molecular biology and the new tools derived from molecular genetics have revolutionized pain research and its translation to therapeutic effectiveness. Bringing together recent advances in modern neuroscience regarding genetic studies in mice and humans and the practicality of clinical trials, Translational Pain Research: From Mouse to Man effectively bridges the gap between basic research and patient care by humanely examining rodent models for pain associated with bone cancer, osteoarthritis, fibromyalgia, and cardiac episodes.Distinguished Team of International Contributors In addition to addressing the groundbreaking technical advances in tract tracing, endocannabinoids, cannabis, gene therapy, siRNA gene studies, and the role of glia, cytokines, P2X receptors and ATP, this book also presents cutting-edge information on: * Nociceptor sensitization * Muscle nociceptors and metabolite detection * Visceral afferents in disease * Innovative rodent model for bone cancer pain * Highly specific receptor cloning * Modular molecular mechanisms relevant to painful neuropathies This sharply focused work also discusses unexpected discoveries derived from brain-imaging studies related to thalamic pain. Translational Pain Research covers the progress made toward bringing laboratory science (much of it at the molecular level) to our understanding of pain phenomena in humans, with the ultimate goal of reducing the suffering that often accompanies pain and its indirect more

Product details

  • Hardback | 432 pages
  • 160 x 236 x 28mm | 762.03g
  • Taylor & Francis Inc
  • CRC Press Inc
  • Bosa Roca, United States
  • English
  • 66 black & white illustrations, 10 colour illustrations, 13 black & white tables
  • 1439812098
  • 9781439812099

Review quote

As the editors of Translational Pain Research: From Mouse to Man state in their preface, "the study of pain is of enormous human importance for the obvious reason that in the course of a lifetime, few individuals manage to evade disruption of their lives by consequential pain experiences." The book is a comprehensive survey of recent pain research that attempts to bring basic science closer to the bedside. The primary intended audience of the book is academic and pharmaceutical industry researchers. Laboratory animal veterinarians and research technicians will also find it a useful reference...In conclusion, Translational Pain Research is a comprehensive review of current research in an area of vital interest to laboratory animal professionals responsible for programs in experimental pain research. The book is highly technical but a non-specialist would find it difficult, but ultimately rewarding. --Journal of the American Association for Laboratory Animal Science, September 2010show more

About Lawrence Kruger

Lawrence Kruger, Distinguished Professor of Neurobiology, University of California, USA Alan Light, Research Professor of Anesthesiology, University of Utah, USAshow more

Table of contents

Painful Multi-Symptom Disorders: A Systems Perspective C. Richard Chapman Neurotrophic Factors and Nociceptor Sensitization Michael P. Jankowski and H. Richard Koerber The Role of Visceral Afferents in Disease Julie A. Christianson and Brian M. Davis Cancer Pain: From the Development of Mouse Models to Human Clinical Trials Juan Miguel Jimenez Andrade and Patrick Mantyh Therapeutic Targeting of Peripheral Cannabinoid Receptors in Inflammatory and Neuropathic Pain States Igor Spigelman Molecular Strategies for Therapeutic Targeting of Primary Sensory Neurons in Chronic Pain Syndromes Ichiro Nishimura, Devang Thakor, Audrey Lin, Supanigar Ruangsri, and Igor Spigelman Transgenic Mouse Models for the Tracing of "Pain" Pathways Allan I. Basbaum and Joao M. Braz Cytokines in Pain Veronica I. Shubayev, Kinshi Kato, and Robert R. Myers Glial Modulation in Pain States: Translation into Humans Ryan J. Horvath, Edgar Alfonso Romero-Sandoval, and Joyce A. De Leo On the Role of ATP-Gated P2X Receptors in Acute, Inflammatory, and Neuropathic Pain Estelle Toulme, Makoto Tsuda, Baljit S. Khakh, and Kazuhide Inoue Myalgia and Fatigue: Translation from Mouse Sensory Neurons to Fibromyalgia and Chronic Fatigue Syndromes Alan R. Light, Charles J. Vierck, and Kathleen C. Light Reflex Autonomic Responses Evoked by Group III and IV Muscle Afferents Jennifer L. McCord and Marc P. Kaufman Central Pain as a Thalamocortical Dysrhythmia: A Thalamic Efference Disconnection? Kerry D. Walton and Rodolfo R. Llinas What Can Neuroimaging Tell Us about Central Pain? D.S. Veldhuijzen, F.A. Lenz, S.C. LaGraize, and J.D. Greenspan Human Brain Imaging Studies of Chronic Pain: Translational Opportunities A. Vania Apkarian Consideration of Pharmacokinetic Pharmacodynamic Relationships in the Discovery of New Pain Drugs Garth T. Whiteside and Jeffrey D. Kennedy Large Animal Models for Pain Therapeutic Development Darrell A. Henze and Mark O. Urban Drug Discovery and Development for Pain Sandra R. Chaplan, William A. Eckert III, and Nicholas I. Carruthers Indexshow more