Transgenesis and Targeted Mutagenesis in Immunology
Investigations into the field of immunology are rapidly expanding with the use of genetically altered mice at the embryonic stage. This laboratory guide provides a complete study of transgenesis and targetted mutagenesis in laboratory mice. It features the contributions of two Nobel Prize winners and addresses the use of mouse models in studying the immune system. Further, it targets gene distribution in embryonic stem cells and their introduction to blastocyte mice models, and analyzes the in vivo functional loss of embryonic cells.
- Hardback | 307 pages
- 158 x 235 x 21mm | 649g
- 01 Jul 1994
- Elsevier Science Publishing Co Inc
- Academic Press Inc
- San Diego, United States
- Illustrations (some col.)
Table of contents
Transgenic mouse models to study VDJ recombination, F. Wartin et al; lymphocyte development and function in T cell receptor and RAG-1 mutant mice, P. Mombearts and S. Tonegawa; RAG-2-deficient blastocyst complementation, J. Chen and F.W. Alt; the role of CD4 and CD8 in determining cell fate in the thymus, C.B. Davis and E.A. Robey; CD4, CD8 and ck gene targetted mice as models for thymic selection, V. Wallace et al; T cell tolerance in T cell receptor transgenic pr/pr mice, J. Mountz et al; thymocyte selection and peripheral tolerance using the lymphocytic choriomeningitis virus as a model antigen, P.S. Ohashi et al; peripheral T cell tolerance - distinct levels and multi-step mechanisms, B. Arnold et al; peripheral tolerance and the CD4 T cell, B. Scott and D. Lo; studies of tolerance, inflammation, and autoimmunity in transgenic mice, S. Antonia et al; immunulogical studies utilizing cytokine transgenic mice, M.-S. Lee and N. Sarvetnick; the effect of MHC Class II encoding transgenes on autoimmunity in NOD mice, R. Quartey-Papafino et al; development and function of the immune system in mice with targetted disruption of the interleukin-2 gene, A. Schimpl et al; immune responses in IL4-deficient mice, G.G. Brusselle et al; manipulation of transgene-encoded self-antigens to explore mechanisms of B cell tolerance, S.B. Hartley and C.C. Goodnow; transgenic mouse model for peripheral B cell tolerance, H. Eibel et al; immunobiology of MHC Class I-deficient mice, D.H. Raulet; MHC Class II mutant mice, M.J. Grusby et al.