Transforming Growth Factor-Beta in Cancer Therapy, Volume II
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Transforming Growth Factor-Beta in Cancer Therapy, Volume II : Cancer Treatment and Therapy

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Transforming Growth Factor- ss in Cancer Therapy, Vols. 1 and 2, provides a compendium of findings about the role of transforming growth factor- ss (TGF- ss) in cancer treatment and therapy. The second volume, Cancer Treatment in Therapy, is divided into three parts.
The companion volume details the role of TGF- ss on basic and clinical biology.
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Product details

  • Hardback | 786 pages
  • 168 x 250 x 30mm | 1,818.9g
  • Humana Press Inc.
  • Totowa, NJ, United States
  • English
  • Illustrated
  • 2008 ed.
  • 15 Tables, black and white; 4 Illustrations, color; 160 Illustrations, black and white; XXVI, 786 p. 164 illus., 4 illus. in color.
  • 1588297152
  • 9781588297150

Review quote

From the reviews:

"This volume ... provide readers with a detailed account of the role of TGF-beta in the development of various cancers in numerous organs. ... This will likely be of interest to those in the field as well as those who are new ... . will be of interest to researchers at all levels. The book will likely attract new researchers and students interested in becoming engaged in new frontiers of cancer therapy. ... This will be a great resource for researchers and clinicians ... ." (James P Luyendyk, Doody's Review Service, June, 2008)
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Back cover copy

Transforming Growth Factor- in Cancer Therapy, Volumes 1 and 2, provides a compendium of findings about the role of transforming growth factor- (TGF-) in cancer treatment and therapy. The second volume, Cancer Treatment and Therapy, is divided into three parts. Part I examines transforming growth factor- in developing and advanced cancers. Part II details transforming growth factor- in cancer treatment and therapy. Part III includes an investigation into the development of inhibitors of transforming growth factor- signaling for therapy.



This volume's companion, Basic and Clinical Biology, examines transforming growth factor- signaling in normal physiology, cancer pathobiology, normal and tumor biology, and inflammation and fibrosis. Together, Transforming Growth Factor- in Cancer Therapy, Volumes 1 and 2, provide researchers and clinicians with a comprehensive and cutting-edge reference for the findings about the role of transforming growth factor- in biology and cancer treatment.
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Table of contents

Transforming Growth Factor-ss in Cancer Therapy
Volume 2: Cancer Treatment and Therapy
Sonia B. Jakowlew, Ph.D., Editor
The Humana Press, Inc., Publisher
TABLE OF CONTENTS


In Memorium for Anita B. Roberts, PhD
John M. McPherson*

Preface
Sonia B. Jakowlew*

Foreward
Carl-Henrick Heldin*

Contributors


Part I. Transforming Growth Factor-ss in Developing and Advanced Cancers

1 Transforming Growth Factor-ss Signaling in Pancreas Development and
Pancreatic Cancer
Sushil Rane*, Huei-Min Lin, Ji-Hyeon Lee, and Wan Jiao

2 Role of Transforming Growth Factor-ss (TGF-ss) in the Pathogenesis of
Head and Neck Squamous Cell
Carcinoma (HNSCC)
Stephen M. Weber, Shi-Long Lu, Sophia Bernstein, and Xiao-Jing Wang*

3 TGF-ss, Smads and Cervical Cancer
Devarajan Karunagaran* and Goodwin Jinesh

4 TGF-ss Signaling and Biglycan in Pancreatic Cancer
Hendrik Ungefroren*

5 TGF-ss Signaling in Endometrial Cancer
Dagmara Piestrzeniewicz-Ulanska*, David H. McGuinnes, and Grant R.
Yeaman

6 TGF-ss Ligands, TGF-AY Receptors, and Lung Cancer
Guiying Wang, Rongmei Zhang, Xiaohua Hu, Jiucun Wang, Lindsey J. Leach,
and Zewei Luo*

7 Role of TGF-ss in Osteolytic Bone Metastases
Laurent Bartholin* and Thesesa A. Guise

8 Hormonal Regulation of Transforming Growth Factor-beta in Breast
Cancer
Miriam Buck* and Cornelius Knabbe

9 TGF-ss Signaling in Esophageal Cancer
Minoru Fukuchi*, Hiroyuki Kato, and Hiroyuki Kuwano

10 TGF-beta and HER2/ErbB2 and Breast Cancer Progression
Natasa Todorovic-Rakovic*

11 TGF-beta dependent T Cell Regulation in Colitis and Colon Cancer
Christoph Becker* and Markus F. Neurath

12 Role of Transforming Growth Factor-beta in the Kidney - Physiology
and Pathology
Elena Gagliardini and Ariela Benigni*

13 Perturbations of TGF-ss Signaling in Leukocytes as Driversof
Leukemogenesis and Epithelial
Tumorigenesis
Lawrence A. Wolfraim* and John J. Letterio

14 Transforming Growth Factor-ss in Brain Functions and Dysfunctions
Denis Vivien*, Karim Benchenane, and Carine Ali

15 Inhibition of TGF-ss Signaling in Multiple Myeloma and it's Bone
Marrow Environment
Hiroshi Yasui, Teru Hideshima, and Kenneth C. Anderson*

16 Key Roles of Smad3 in TGF-ss Responses in the Prostate
Kyung Song and David Danielpour*

17 Smad Signaling in Leukemic Growth and Differentiation: Crosstalk
Between Smad and Multiple
Pathways Through Activation of the TGF-ss Type I Receptor
Francis W. Ruscetti*, Salem Akel, Maria Birchenall-Roberts, Zhouhong
Cao, and Anita Roberts


Part II. Transforming Growth Factor-ss in Cancer Treatment and Therapy

18 High Throughput Screening of Protein Interaction Networks in the
TGFss Interactome: Understanding the
Signaling Mechanisms Driving Tumor Progression
Miriam Barrios-Rodiles, Alicia Viloria-Petit, Kevin R. Brown, Igor
Jurisica, and Jeffrey L.
Wrana*

19 Tumor Suppressor and Pro-Progression Roles for TGF-ss in Breast Cancer
Ethan Kohn* and Binwu Tang

20 Tumor Suppressors p53 and TGF-ss Converge to Regulate the
Alpha-fetoprotein - Oncodevelopmental
Tumor Marker
Deepti S. Wilkinson and Michelle Craig Barton*

21 TGF-ss1: Roles in DNA Damage Responses
Kumari L. Andarawewa, Julie Kirshner, Joni D. Mott, and Mary Helen
Barcellos-Hoff*

22 The Rationale For and Effects of Targeting TGF-beta for Glioma
Therapy
Anita B. Hjelmeland* and Jeremy N. Rich

23 Tumor Suppressor Function of TGF-ss1 in T Cells
Ramireddy Bommireddy* and Thomas Doetschman

24 Therapeutic Effects of Adenovirus-mediated Gene Transfer of TGF-ss Signal Antagonists on Undesirable
Epithelial-mesenchymal Transition and Neovascularization
Shizuka Saika*



25 Role of TGF-ss in Tumor Protection
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Review Text

From the reviews:

"This volume ... provide readers with a detailed account of the role of TGF-beta in the development of various cancers in numerous organs. ... This will likely be of interest to those in the field as well as those who are new ... . will be of interest to researchers at all levels. The book will likely attract new researchers and students interested in becoming engaged in new frontiers of cancer therapy. ... This will be a great resource for researchers and clinicians ... ." (James P Luyendyk, Doody's Review Service, June, 2008)
show more