Transcription Factors and Human Disease
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Transcription Factors and Human Disease

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Description

Transcription factors are essential mediators of the genetic programs that control development and physiology. This exciting book presents current knowledge of transcription factors from two viewpoints. First, the basic science of transcriptional regulation is discussed. Second, inherited human diseases attributable to mutations in DNA sequences encoding transcription factors or their cognate binding sites are described. Readers are also introduced to the involvement of transcription factors in somatic cell genetic disease (cancer) and epigenetic disease (teratogenesis).show more

Product details

  • Hardback | 382 pages
  • 152 x 236 x 30mm | 920.81g
  • Oxford University Press Inc
  • New York, United States
  • English
  • New
  • numerous illustrations
  • 0195112393
  • 9780195112399

Table of contents

Part I: Transcriptional Regulation ; 1. Gene Expression and Transcriptional Regulation ; 2. Cis-acting Transcriptional Regulatory Elements ; 3. Trans-acting Factors ; Part II: Transcriptional Pathophysiology ; 4. Mutations in Cis-acting Transcriptional Regulatory Elements ; 5. Mutations in Genes Encoding Transcription Factors: The Nuclear Receptor Superfamily ; 6. Other Zinc-Finger Proteins: WT1 and GL13 ; 7. PAX Proteins ; 8. bHLH Proteins ; 9. Homeodomain Proteins ; 10. HMG Domain Proteins ; 11. POU Domain Proteins ; 12. Other Transcriptional Factor Families ; 13. Co-activators ; 14. General Transcription Factors ; 15. Somatic Cell Genetic Disease: Cancer ; 16. Epidenetic Disease: Teratogenesisshow more

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