Transactions of the American Ophthalmological Society Annual Meeting Volume 57
This historic book may have numerous typos and missing text. Purchasers can usually download a free scanned copy of the original book (without typos) from the publisher. Not indexed. Not illustrated. 1921 edition. Excerpt: ...cause of tumor development or of any other definite extrinsic influence, and yet we are all familiar with the many instances in which injurious influences of all sorts preceded the development of tumors, making the causative relation between them extremely suggestive. Nevertheless, we cannot conceive of such injuries causing tumor growth without assuming the existence of some abnormality in the tissue involved. The irritants which, by Virchow, were called formative irritants, and which are now looked upon merely in the light of contributory factors in tumor development, are not necessarily the result of one direct violence, but may be due to long-continued influence of mechanical, chemical, or bacterial irritation, associated with inflammatory infiltration. Common examples of this kind are seen in the pipesmoker's epithelioma of the lip, malignant uterine growths following long-continued acrid discharge, etc. In considering the exogenous causes of tumor development, it is quite natural to look to parasites, either of animal or vegetable nature, as etiologic possibilities, though up to the present time growths have not been produced experimentally by inoculation nor have bacterial inclusions been demonstrated in cells of new-growths. McCallu1n1 believes that bacteria, in order to cause cell growth, must be so included in the growing cells as to multiply with them and accompany them wherever they go, since otherwise it would seem impossible that they could maintain their stimulating effect upon the cells which have been transplanted to distant organs. Some twenty years ago pathologists believed to have found withinthe protoplasm of tumor cells bodies which they considered as protozoa. As late as 1913 Rohdenburg2 expressed the belief...
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