Toxicology of Chemical Mixtures
Although toxicologic studies in the laboratory often focus on a single chemical, in the larger world, mixtures of chemicals are routinely encountered. Toxicology of Chemical Mixtures examines the mechanisms of interactions and health effects stemming from chemical mixtures in the environment. Toxicologists, pharmacologists, environmental scientists, and professionals involved in environmental clean-ups will benefit from its content. Emphasis is on low-level, long-term exposure.
- Hardback | 692 pages
- 162.1 x 237.2 x 35.1mm | 1,283.92g
- 18 May 1994
- Elsevier Science Publishing Co Inc
- Academic Press Inc
- San Diego, United States
Table of contents
Introduction to the toxicology of chemical mixtures; real life case studies or special problem-related situations - love canal - the development of the toxicologic evaluation of its complex chemical contamination; toxicological studies on mixtures of chemical contaminants in the great lakes; health effect studies on recycled drinking water from secondary waste water; assessing the carcinogenic potency of coal tar; toxicology of chemical mixtures derived from hazardous waste sites or applications of pesticides and fertilizers; diesel exhaust - an approach for the study of the toxicity of chemical mixtures; toxicologic problems associated with pesticide mixtures and pesticide impurities - identification of potential carcinogenic hazards associated with consuming seafood contaminated with mixtures of diverse and "unknown" chemical composition; target organ toxicity or special toxicologic responses related to chemical mixture exposures - immune alterations resulting from exposure to chemical mixtures; cytogenetic effects from chemical mixture exposures; multiple chemical exposure and risks of adverse reproductive function and outcome; mechanism of the interactive amplification of halomethane hepatotoxicity and lethality by other chemicals; nephrotoxicity resulting from multiple chemical exposures and chemical interactions; effects of low dose level exposure to multiple carcinogens in combination; contemporary issues - new approaches to bioassay - and biomarker - directed identification and mutation spectra; physiologically based pharmacokinetic modelling of chemical mixtures; the application of physico-chemical concepts to mechanistic elucidation of toxicologic interactions; defining populations potentially exposed to chemical waste mixtures using computer-aided mapping and analysis; challenges for in situ bioremediation of chemical mixtures; chemical mixture toxicity assessment using an alternative-species model - applications, opportunities, and perspectives; regulatory approaches and problems in risk assessments of chemical mixtures; statistical methods for the toxicological evaluation of the additivity assumption; analysis of chemical combinations - relating isobolograms to response surfaces; the potential effects of chemical mixtures on the carcinogenic process within the context of the mathematical multistage model.
This book contains much valuable and some unique information about toxicological problems of the real world. --HUMAN AND EXPERIMENTAL TOXICOLOGY Good, cutting-edge material for toxicologists, biomedical scientists and pharmacologists! --VET HUMAN TOXICOLOGY