Thyroid Cancer

Thyroid Cancer : A Comprehensive Guide to Clinical Management

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are new to this edition. The authors provide not only the The second edition of Thyroid Cancer: A Comp- most current review of their respective areas, but also their hensive Guide to Clinical Management marks the pub- own recommendations and approach. The reader is fo- cation of a markedly updated and expanded volume that warned that in many cases these approaches, albeit rooted covers all aspects of the etiology, pathogenesis, diag- sis, initial treatment, and long-term management of all in available data, may be empiric rather than based varieties of thyroid cancer. Like the first edition, it will upon clear-cut results of well-controlled clinical t- als. Nevertheless, controversial issues are examined serve as a valuable reference source for pathologists, and evidence-based recommendations are presented endocrine surgeons, endocrinologists, nuclear medicine when available. physicians, and oncologists. However, the biggest There are updated chapters on our current state change is that the second edition is significantly enlarged and expanded to encompass important and extensive of knowledge of the molecular changes in thyroid treatments of more topics related to nuclear medicine. cancer, molecular markers, and how targeted the- pies are being developed. New therapeutic trials of Nuclear medicine physicians and procedures play a key redifferentiation agents to restore the sodium iodide role in the management of thyroid cancer patients and in symporter when lacking and more traditional che- retrospect, a comprehensive discussion of topics related therapies are discussed, with referral sources listed for to that field was somewhat lacking in the first edition.show more

Product details

  • Hardback | 736 pages
  • 221 x 284.5 x 33mm | 2,222.63g
  • Humana Press Inc.
  • Totowa, NJ, United States
  • English
  • Revised
  • 2nd ed. 2006
  • 409 black & white illustrations, biography
  • 1588294625
  • 9781588294623

Review quote

From the reviews "...our present state of knowledge provides clinicians a wide variety of diagnostic and therapeutic modalities to effectively manage this group of cancers. I believe the knowledge contained in this text will give the practicing clinician the necessary information to provide patients the latest and best therapeutic techniques."-Foreword by Ernest L. Mazzaferri, MD "This is an excellent comprehensive up-to-date text that is scholarly and complete, yet thoroughly readable. It provides guidance to clinicians and others interested in thyroid cancer based on a combination of a distillate of the published literature [which is fully documented] and the personal experience of the expert author of each chapter...the text reads quickly... I recommend this text to anyone interested in an up-to-date, detailed, clinical guideline to the management of patients with thyroid cancer and the clinical science behind the recommendation."-Journal of Nuclear Medicine "This book illustrates the importance of the multidisciplinary approach available in major medical centers for the care of patients with thyroid cancer. The wide-ranging topical nature of this book will interest those working in many fields of medicine. It should be essential reading for trainees in endocrinology, pathology, imaging, nuclear medicine, surgery, and oncology, as well as for specialists in those fields."-The New England Journal of Medicine "The book is truly unique and is a critical addition to the contemporary endocrine texts held by general physicians, surgeons, and endocrinologists alike. The book is designed to be a comprehensive guide for clinical management of thyroid cancer and in this regard, is an overwhelming success...One of the most important aspects of this text is the multidisciplinary emphasis provided to all the sub specialists who attend patients with thyroid neoplasms... The book is uniquely organized with several chapters exclusively devoted to the surgical and medical management of individual types of thyroid cancer. This organization is important, because it helps emphasize that each thyroid cancer is unique and not necessarily amenable to one standardized form of treatment...A parallel emphasis of the book is the reliance on evidence-based practice...each chapter is thoroughly referenced, making it easy for the reader to ascertain the original studies on which these conclusions and controversy are based...One of the strengths of this book is the devotion of separate chapters to the management of unique thyroid cancers and unique patients...The text is right up -to- date with regards to the molecular biology of thyroid cancers, the management of medullary thyroid carcinoma, the use of alternative imaging techniques and the use of rhTSH for scanning patients with a history of thyroid cancer...To conclude, this is a unique and important text for all practitioners caring for patients with thyroid cancer. I congratulate the Editor and Authors for their success in detailing this complex and rapidly changing field." ------Trends in Endocrinology and Metabolism "...recommended for anyone who would like a comprehensive reference on the practical aspects of thyroid cancer management." - Head & Neck "This comprehensive book brings an instructive review of present knowledge on the pathology, etiology, epidemiology, diagnostic methods and the methods of surgical, radioiodine and chemotherapeutic treatment of various forms of thyroid cancer. Written by outstanding experts and professionally edited by Leonard Wartofsky, it may be considered of substantial utility to all physicians dealing with thyroid diseases." - Endocrine Regulations From the reviews of the second edition: "An excellent, truly comprehensive book that covers the etiology, pathogenesis, and clinical management of all forms of thyroid cancer. ... While the book is written clearly enough to be accessible to physicians in training, it will probably be most useful for practicing physicians. The targeted readers include endocrinologists, endocrine surgeons, nuclear medicine specialists, pathologists, and oncologists. ... This is an outstanding textbook ... . surely a work to be added to the library of every clinician taking care of patients with thyroid cancer." (Brian W. Kim, Doody's Review Service, May, 2006) "This book includes almost twice as many chapters and contributors as the first edition. I especially enjoyed the addition of patient-focused content, including lists of useful books and Web sites and practical advice regarding radioiodine treatment ... . an excellent, up-to-date book that is of practical value across all specialties involved in the management of thyroid cancer. It also provides a scholarly overview of the evidence base." (Jayne Franklyn, The New England Journal of Medicine, July, 2006) "This is the second edition of an outstanding textbook edited by Leonard Wartofsky and Douglas Van Nostrand. The editors are to be congratulated on bringing together a remarkable array of multidisciplinary authors, who cover every topic pertaining to the clinical management of thyroid cancer. ... Overall, I would highly recommend this book to all practitioners and associated specialties involved in the management of thyroid cancer. The book is clearly and concisely written, well illustrated ... . an excellent textbook." (John Watkinson, Annals of the Royal College of Surgeons of England, Vol. 90, June, 2008)show more

Back cover copy

In a massive updating of the highly acclaimed Thyroid Cancer: A Comprehensive Guide to Clinical Management, Drs. Leonard Wartofsky, Douglas Van Nostrand, and an expert group of contributing authors present a wealth of new information and insights on every aspect of the etiology, pathogenesis, diagnosis, initial treatment, and long-term management of all varieties of thyroid cancer. Paramount to this new edition is a thorough treatment of the nuclear medical aspects of diagnosing and managing the thyroid cancer patient. This includes extensive discussion of isotopes, isotope uptake and scanning procedures, radioiodine ablation and dosimetry (with or without recombinant human TSH), stunning, octreotide and FDG-PET scanning, and various alternative imaging modalities. Additional highlights include management of the scan-negative and thyroglobulin-positive patient, ultrasound of the lymph nodes, local adjuncts to therapy of metastases, low iodine diets and cookbooks, future directions in therapy, and alternative therapies when traditional surgery and radioactive iodine fail. Encyclopedic and definitive, Thyroid Cancer: A Comprehensive Guide to Clinical Management, Second Edition, offers clinical endocrinologists, nuclear medicine physicians, pathologists, oncologists, endocrine surgeons, and internists an authoritative guide to the optimal diagnosis and treatment of thyroid cancer today.show more

Table of contents

Part I. General Considerations I: Thyroid Cancer Anatomy and Physiology of the Thyroid Gland: Clinical Correlates to Thyroid Cancer Nikolaos Stathatos Epidemiology of Thyroid Cancer James J. Figge Molecular Pathogenesis of Thyroid Cancer James J. Figge, Nikolai A. Kartel, Dima Yarmolinsky, and Gennady Ermak Molecular Aspects of Thyroid Cancer in Children Gary L. Francis Oncogenes in Thyroid Cancer Katherine B. Weber and Michael T. McDermott Apoptosis in Thyroid Cancer Su He Wang and James R. Baker, Jr. Radiation-Induced Thyroid Cancer James J. Figge, Timothy Jennings, Gregory Gerasimov, Nikolai A. Kartel, Dima Yarmolinsky, and Gennady Ermak Classification of Thyroid Malignancies Yolanda C. Oertel Staging of Thyroid Cancer Leonard Wartofsky Thyroid Cancer in Children and Adolescents Merrily Poth Recombinant Human Thyrotropin Matthew D. Ringel and Stephen J. Burgun Part II. General Considerations II: Nuclear Medicine History of the Role of Nuclear Medicine in the Thyroid Gland and its Diseases: A Personal Perspective Henry N. Wagner, Jr. Prophylaxis against Radiation Exposure from Radioiodine Jacob Robbins and Arthur B. Schneider Radioiodine Whole Body Imaging Frank B. Atkins and Douglas Van Nostrand Primer and Atlas for the Interpretation of Radioiodine Whole-Body Scintigraphy Douglas Van Nostrand, Reetha Bakthula, and Frank B. Atkins False-Positive Radioiodine Scans in Thyroid Cancer Brahm Shapiro, Vittoria Rufini, Ayman Jarwan, Onelio Geatti, Kimberlee J. Kearfott, Lorraine M. Fig, Ian D. Kirkwood, John E. Freitas, and Milton D. Gross Part III. The Thyroid Nodule The Thyroid Nodule: Evaluation, Risk of Malignancy, and Management Leonard Wartofsky Fine Needle Aspiration: Technique Yolanda C. Oertel Thyroid Nodules: Cellular and Biochemical Markers for Malignancy Kathleen A. Prendergast Radionuclide Imaging of Thyroid Nodules Douglas Van Nostrand Ultrasonic Imaging of the Neck in Patients with Thyroid Cancer Manfred Blum Thyroid Nodules and Cancer Risk: Surgical Management Orlo H. Clark Part IV. Well-Differentiated Thyroid Cancer: Papillary Carcinoma A. Presentation Papillary Cancer: Clinical Aspects Leonard Wartofsky Surgical Approach to Papillary Cancer Orlo H. Clark Papillary Carcinoma: Cytology and Pathology Yolanda C. Oertel and James E. Oertel Part IV. Well-Differentiated Thyroid Cancer: B. Initial Management Prescribed Activity for Radioiodine Ablation Douglas Van Nostrand Thyroid Remnant Radioiodine Ablation with Recombinant Human Thyrotropin R. Michael Tuttle and Richard J. Robbins Part IV. Well-Differentiated Thyroid Cancer: C. Surveillance Follow-Up Strategy in Papillary Thyroid Cancer Henry B. Burch Levothyroxine Therapy and Thyrotropin Suppression Leonard Wartofsky Thyroglobulin and Thyroglobulin Antibodies: Measurement and Interferences D. Robert Dufour Diagnosis of Recurrent Thyroid Cancer in Patients with Positive Antithyroglobulin Antibodies Matthew D. Ringel Surveillance Radioiodine Whole-Body Scans Douglas Van Nostrand Radionuclide Imaging and Treatment of Thyroid Cancer in Children Gary L. Francis Positron Emission Tomography in Well-Differentiated Thyroid Cancer I. Ross McDougall Alternative Thyroid Imaging Anca M. Avram, Karen C. Rosenspire, Stewart C. Davidson, John E. Freitas, and Milton D. Gross The 'Stunning' Controversy. A. Stunning: Untoward Effect of 13show more

Review Text

From the reviews"...our present state of knowledge provides clinicians a wide variety of diagnostic and therapeutic modalities to effectively manage this group of cancers. I believe the knowledge contained in this text will give the practicing clinician the necessary information to provide patients the latest and best therapeutic techniques."-Foreword by Ernest L. Mazzaferri, MD"This is an excellent comprehensive up-to-date text that is scholarly and complete, yet thoroughly readable. It provides guidance to clinicians and others interested in thyroid cancer based on a combination of a distillate of the published literature [which is fully documented] and the personal experience of the expert author of each chapter. . .the text reads quickly. . . I recommend this text to anyone interested in an up-to-date, detailed, clinical guideline to the management of patients with thyroid cancer and the clinical science behind the recommendation."-Journal of Nuclear Medicine"This book illustrates the importance of the multidisciplinary approach available in major medical centers for the care of patients with thyroid cancer. The wide-ranging topical nature of this book will interest those working in many fields of medicine. It should be essential reading for trainees in endocrinology, pathology, imaging, nuclear medicine, surgery, and oncology, as well as for specialists in those fields."-The New England Journal of Medicine"The book is truly unique and is a critical addition to the contemporary endocrine texts held by general physicians, surgeons, and endocrinologists alike. The book is designed to be a comprehensive guide for clinical management of thyroid cancer and in this regard, is an overwhelming success...One of the most important aspects of this text is the multidisciplinary emphasis provided to all the sub specialists who attend patients with thyroid neoplasms... The book is uniquely organized with several chapters exclusively devoted to the surgical and medical management of individual types of thyroid cancer. This organization is important, because it helps emphasize that each thyroid cancer is unique and not necessarily amenable to one standardized form of treatment...A parallel emphasis of the book is the reliance on evidence-based practice...each chapter is thoroughly referenced, making it easy for the reader to ascertain the original studies on which these conclusions and controversy are based....One of the strengths of this book is the devotion of separate chapters to the management of unique thyroid cancers and unique patients...The text is right up -to- date with regards to the molecular biology of thyroid cancers, the management of medullary thyroid carcinoma, the use of alternative imaging techniques and the use of rhTSH for scanning patients with a history of thyroid cancer...To conclude, this is a unique and important text for all practitioners caring for patients with thyroid cancer. I congratulate the Editor and Authors for their success in detailing this complex and rapidly changing field." ------Trends in Endocrinology and Metabolism"...recommended for anyone who would like a comprehensive reference on the practical aspects of thyroid cancer management." - Head & Neck"This comprehensive book brings an instructive review of present knowledge on the pathology, etiology, epidemiology, diagnostic methods and the methods of surgical, radioiodine and chemotherapeutic treatment of various forms of thyroid cancer. Written by outstanding experts and professionally edited by Leonard Wartofsky, it may be considered of substantial utility to all physicians dealing with thyroid diseases." - Endocrine Regulations From the reviews of the second edition:"An excellent, truly comprehensive book that covers the etiology, pathogenesis, and clinical management of all forms of thyroid cancer. ... While the book is written clearly enough to be accessible to physicians in training, it will probably be most useful for pshow more

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