Therapeutic Strategies in Cancer Biology and Pathology

Therapeutic Strategies in Cancer Biology and Pathology

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Currently, intensive effort is being directed toward the identification of molecular targets that can provide approaches to the development of novel therapeutic strategies in cancer management. This book focuses on metastasis-associated genes, metastasis promoter and suppressor genes, which relate specifically to behavioral alterations of cancer cells in epithelial mesenchymal transition, cancer stem cell maintenance and propagation, and to the acquisition of invasive and metastasis faculty. The function of these genes has implications for cell cycle regulation and cell proliferation and so constitute an essential element in cancer growth and dissemination. The emphasis in this book is on how appropriate these genes are as molecular targets and how practicable are the constituents of their signal transduction systems as potential candidates and how accessible they are to targeted therapy. Written in a straightforward and clear style with background information supporting the new research, this book will be useful for students and researchers in cancer therapies.
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Product details

  • Paperback | 310 pages
  • 152 x 229 x 16.51mm | 417.3g
  • United States
  • English
  • Reprint
  • 0128103426
  • 9780128103425

Table of contents


Part I: RNA interference in genetic regulation 1. The biogenesis and functions of microRNAs 2. Association of miRNAs with pathogenesis 3. Are miRNAs suitable targets for cancer therapy?

Part II: EMT associated gene targeting 4. Hedgehog signalling in EMT 5. Targeted inhibition of Hh, Wnt, TGF-ss signalling complex 6. Encountering aberrant Wnt signalling 7. Therapeutic targeting of TGF-ss signalling 8. EGFR signalling in EMT

Part III: Therapeutic deployment of tumour and metastasis promoter gene function 9. S100A4 as a potential target 10. MTAs in cancer invasion and metastasis

Part IV: Genetic determinants of tumour and metastasis suppression 11. Metastasis suppressor gene nm23 and manipulation of its expression 12. The metastasis suppressor KiSS-1 gene 13. KAI1 (CD82) suppresses metastasis, cell proliferation and invasion 14. 14-3-3 proteins in normal and tumour cell biology 15. Suppressor function of NDRG1 (N-myc downstream-regulated gene-1) 16. The ING (inhibitor of growth) suppressor gene 17. The BRCA1 and BRCA2 suppressor genes 18. BRMS1 (breast cancer metastasis suppressor 1) gene 19. Maspin, a postulated tumour suppressor 20. EPB41L3 and CADM1 tumour suppressor function

Part V: Signalling and transcription regulators as prospective candidates 21. Is MKK a metastasis suppressor? 22. RKIP (The Raf kinase inhibitor protein) suppresses invasion and metastasis) 23. CRSP3 metastasis suppressor 24. The suppressor function of TXNIP (Thioredoxin interacting protein-2) 25. The essence of the Hippo signalling system 26. HIC1 (hypermethylated in cancer 1) suppressor gene 27. The DLC suppressor genes 28. The LKB1 (STK11) suppressor gene 29. PLCD1 (phospholipase C 1) suppresses tumorigenesis 30. Inhibitor of DNA binding proteins (IDs) in tumours 31. PDCD4 (Programmed Cell Death 4)

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Review quote

"The major motivation for this volume on cancer therapeutic strategies is to identify items of therapeutic interest in the biological functioning of high-profile metastasis suppressor and promoter genes and uncover links and nodes of their signaling pathways in order to directly or indirectly countermand the biological effects of these genes."--Reference & Research Book News, December 2013
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About Gajanan V. Sherbet

Dr. G.V. Sherbet is DSc (Doctor of Science) London University; FRCPath (Fellow of the Royal College of Pathologists). He was a member of the scientific staff at the Chester Beatty Research Institute and University College Medical School of London, and Deputy Director of the Cancer Research Unit in the Medical School of University of Newcastle upon Tyne. He has held several prestigious fellowships, such as the Beit Memorial and the Williams and Cancer Research Campaign fellowships. Dr Sherbet is Adjunct professor at the Institute for Molecular Medicine Huntington Beach CA. He is on the editorial boards of many international scientific and medical journals.
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