Excerpt from The Therapeutic Gazette, 1898, Vol. 22: A Monthly Journal of General, Special and Physiological Therapeutics
One drug only is markedly efficient to pro duce skin action, viz., jaborandi or its active principle pilocarpine. The latter is the most convenient preparation, and the best method of administering it is by the hypodermic syringe. One-fourth of a grain should be the maximum dose, and a powerful eﬂ'ect may be produced if it is associated with artificial warmth. The patient should also be clad in a sweater or lie naked between blankets rather than in a muslin shirt or between muslin sheets. Should dangerous edema of the lungs arise it may easily be controlled by a hypo dermic injection of Th or 310 of a grain of atropine.
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