The Theoretical Foundations of Cancer Chemotherapy Introduced by Computer Models
This book is intended for oncologists, pharmacologists, biochemists, biomathematicians, and cell biologists in academia as well as in industry; graduate, medical, and senior undergraduate students in the biological sciences. This is the first book to describe the principles of cancer chemotherapy quantitatively, using computer modelling. It includes a computer program on disk that allows the user to model tumour biology and drug effects. This ability to treat imaginary tumours with imaginary drugs and to change the properties of each makes it possible to use a trial and error approach to the understanding of the principles of chemotherapy.
- Mixed media product | 396 pages
- 165.1 x 230 x 25.4mm | 805g
- 01 Oct 1992
- Elsevier Science Publishing Co Inc
- Academic Press Inc
- San Diego, United States
- bibliography, index
Table of contents
Introduction - models as tools for teaching and research; cell cycle effects of drugs; anticancer drug selectivity; quiescent cells, differentiated cells and lost cells; pharmacokinetic models; invasion and metastasis; the blood-brain barrier; cancer treatment and the immune response; drug resistance and its implications for treatment strategy; the growth kinetics of large tumours; the biochemical basis of anticancer drug selectivity; biochemical principles of drug interaction; cytokinetics, pharmacokinetics, and inhibition kinetics - a unified model. Appendices: chemical structures of the anticancer drugs studied by the models; notes on the programming.