A Text-Book of Pharmacology and Therapeutics; Or, the Action of Drugs in Health and Disease

A Text-Book of Pharmacology and Therapeutics; Or, the Action of Drugs in Health and Disease

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This historic book may have numerous typos and missing text. Purchasers can download a free scanned copy of the original book (without typos) from the publisher. Not indexed. Not illustrated. 1915 edition. Excerpt: ...rather than to the. solution. An interesting analogy has been drawn by Gros between cocaine and the general narcotics of the alcohol-chloroform series, which also have some action on nerve fibres and terminations when they are applied directly. They act in lower dilution on the central nerve cells, however, and do not affect the sensory fibres more than the motor, while the concentration of cocaine which affects the nerve cell is less distant from that which acts on the peripheral fibre and it acts much more strongly on the sensory than the motor nerves. Most of the other natural alkaloids resemble cocaine in many points of their action, as far as they have been investigated, but some of the artificial compounds present divergences from the general type. Thus a number of them do not produce anaesthesia, and some of them depart entirely from the typical cocaine action. Cocamine is often said to be a cardiac poison, but its action on the heart seems to resemble in general that of cocaine. It has, however, a much more intense action on muscular tissue, which it, like caffeine, throws into rigor mortis. Its antesthetic power is very small. Some authorities regard the muscular action of caffeine as an important factor in its preventing fatigue, and the presence of cocamine in the coca leaves might be used to explain the similar effects induced by these, but the quantity is probably too small to have any noticeable action. Benzoylecgonine is a comparatively weak body, which produces symptoms resembling caffeine--increased reflex excitability, muscular stiffness, and rigor--and ecgonine is still less active, but elicits similar effects in frogs. Cocaine Habit.--Since the introduction of cocaine into general therapeutic use, numerous cases of the...show more

Product details

  • Paperback | 354 pages
  • 185.42 x 243.84 x 22.86mm | 635.03g
  • Rarebooksclub.com
  • Miami Fl, United States
  • English
  • black & white illustrations
  • 1236664124
  • 9781236664129