Targeting of Drugs: Strategies for Gene Constructs and Delivery

Targeting of Drugs: Strategies for Gene Constructs and Delivery

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Description

Gene therapy, developed as an alternative to the use of therapeutic proteins, can be hampered by nuclease degradation of the plasmid DNA, its inability to access target cells, or - when within cells - to enter the nucleus and transfect these efficiently. This text deals with developments in circumventing the problems of direct plasmid administration by the use of viral or non-viral vectors, Representatives from both camps of therapy discuss the challenges and opportunities of the two approaches and present late-20th-century progress with a variety of constructs. These include viruses such as retroviruses, lentiviruses, poxviruses, alphavirus, herpevirus, and parvovirus. Non-viral constructs are represented by polycations, polymers, cationic liposomes and nanoparticles.show more

Product details

  • Hardback | 350 pages
  • 167.6 x 243.8 x 20.3mm | 612.36g
  • IOS Press
  • IOS Press,US
  • Amsterdam, United States
  • English
  • 1586030094
  • 9781586030094