Target Discovery and Validation Reviews and Protocols: Emerging Molecular Targets and Treatment Options Volume 2
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Target Discovery and Validation Reviews and Protocols: Emerging Molecular Targets and Treatment Options Volume 2

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Description

The aim of "Target Discovery and Validation" is to discuss the recent progress in our understanding of the molecular mechanisms of most human diseases and technical advances in target identification and validation. The covered topics include cancers, autoimmune diseases, cell signaling, gene profiling technologies, tumor immunology, tumor editing, immune tolerance and transgenic animals.show more

Product details

  • Hardback | 345 pages
  • 157.5 x 231.1 x 25.4mm | 680.4g
  • Humana Press Inc.
  • Totowa, NJ, United States
  • English
  • biography
  • 1588298906
  • 9781588298904

Review quote

From the reviews: "...provide a thorough review of the most cutting-edge methods available for each step in drug target identification, validation, and clinical applications." -Anticancer Research "Review current methods for drug target discovery and validation. ... the chapters are generally well written and clear, and provide extensive references to the current literature. Overall ... provide useful overviews that would provide entry into this field. Novice and more experienced researchers ... would find useful information ... ." (Jonathan B. Chaires, ChemMedChem, Issue 3, 2008)show more

Table of contents

Part II: Emerging molecular targets and treatment options 1. Druggable signaling proteins Mouldy Sioud and Marianne leirdal 2. DNA methylation and histone modifications in patients with cancer: Potential prognostic and therapeutic targets Michael Herranz and Manel Esteller 3. Wnt signaling as therapeutic target for cancer Andreas Herbst and Frank Thomas Kolligs 4. The NG2/HMP proteoglycan as a cancer therapeutic target Martha Chekenya and Heike Immervoll 5. Heterotrimeric G proteins and disease Oyvind Melien 6. High Mobility Group Box1 isoforms as potential therapeutic targets in sepsis William Parrish and Luis Ulloa 7. Antisense oligonucleotides: Target validation and development of systemically-delivered therapeutic nanoparticles Chuanbo Zhang, Jin Pei, Deepak Kumar, Isamu Sakabe, Howard E. Boudreau, Prafulla C. Gokhale, and Usha N. Kasid 8. Therapeutic applications of RNA-based aptamers de Franciscis Vittorio 9. Guidelines for the selection of effective siRNA sequences for functional genomics and therapeutic applications Kumiko Ui-Tei, Yuki Naito, and Kaoru Saigo 10. Suppression of apoptosis in the liver by systematic and local delivery of siRNA Lars Zender and Stefan Kubicka 11. Inhibition of tumour growth by intratumoral delivery of siRNAs Seyedhossein Aharinejad, Mouldy Sioud, Trevor Lucas, and Dietmar Abraham 12. Validation of telomerase and survivin as anticancer therapeutic targets using ribozymes and small interfering RNAs Nadia Zaffaroni, Marzia Pennati, and Marco Folini 13. Collagen-induced arthritis in mice: A major role for TNFa Richard O. Williams 14. Novel opportunities for therapeutic targeting in systemic autoimmune diseases Meryem Ouarzane and Moncef Zouali 15. Regulatory RNAs: Future perspectives in diagnosis, prognosis and individualized therapy ProvostPatrick 16. Therapeutic options and individualized medicine Mouldy Sioud Oyvind Melien NB. Chapters 8 and 15, which I am now editing, will be send on Monday.show more

Review Text

From the reviews: "...provide a thorough review of the most cutting-edge methods available for each step in drug target identification, validation, and clinical applications." -Anticancer Research "Review current methods for drug target discovery and validation. ... the chapters are generally well written and clear, and provide extensive references to the current literature. Overall ... provide useful overviews that would provide entry into this field. Novice and more experienced researchers ... would find useful information ... ." (Jonathan B. Chaires, ChemMedChem, Issue 3, 2008)show more