Studies from the Rockefeller Institute for Medical Research Volume 42

Studies from the Rockefeller Institute for Medical Research Volume 42

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This historic book may have numerous typos and missing text. Purchasers can usually download a free scanned copy of the original book (without typos) from the publisher. Not indexed. Not illustrated. 1922 edition. Excerpt: ...were found when the intervals between analyses were 5 to 30 minutes, as in Tables IX, XI, and XXII, or Table xxv. Sheep 2.' Normal. several hours as in other tables. The observations suggest that the distribution of sugar between plasma and corpuscles is governed not by permeability in any proper sense but by a coefficient of solubility between the two media. Table xxvi. Permeability of Sheep Corpuscles in Vitro. CONCLUSIONS. 1. No specific alteration of the distribution of sugar between the blood plasma and corpuscles was found in experiments with different quantities and modes of administration of glucose, different degrees of pancreatectomy and diabetes, lipemia, acidosis, exercise, cold, or different levels of the renal threshold. 2. The concentration of sugar in the corpuscles is normally a little below that in the plasma. The discrepancy in favor of the plasma generally becomes greater as the blood sugar rises. These relations hold good in the several animal species examined, and in experiments in vivo and in vitro. The statement that in the declining stage of hyperglycemia the corpuscles retain sugar longer than the plasma was not confirmed. The concentration in the corpuscles rarely equals that in the plasma, and the finding of an excess in the corpuscles is probably to be interpreted as an analytical error. 3. The term permeability as commonly used in relation to the sugar content of the corpuscles carries the idea that this is governed by a partially permeable membrane surrounding the corpuscle, and further that the solubility of glucose in the corpuscle substance is the same as in the plasma. This conception of permeability has received support from the assertions that the corpuscles take up and give off sugar more slowly more

Product details

  • Paperback | 196 pages
  • 189 x 246 x 11mm | 358g
  • United States
  • English
  • black & white illustrations
  • 1236806840
  • 9781236806840