Studies from the Rockefeller Institute for Medical Research Volume 40

Studies from the Rockefeller Institute for Medical Research Volume 40

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This historic book may have numerous typos and missing text. Purchasers can usually download a free scanned copy of the original book (without typos) from the publisher. Not indexed. Not illustrated. 1922 edition. Excerpt: ...and was identical in every way with the product obtained by the direct method. The yield was 80 per cent of the theory. 0.1297 gm. of substance; 11.5 cc. of N (19.5C, 742 mm.). Calculated for CgHnOAs: N, 10.22 per cent. Found: N, 10.11 per cent. 3 German Patent, No. 204,664. No. 1, pp. 1-16. CEPHALIN. VII. The Glycerophosphoric Acid Of Cephalln. By P. A. LEVENE And IDA P. ROLF. (From the Laboratories of The Rockefeller Institute for Medical Research.) (Received for publication, August 2, 1919.) The generally accepted structural formula of cephalin is as follows: H2C-O-COCnH, I HC--0--COC, H,6 I H, C-0-P = 0 / OH 0-CHjCH, NH, This conception presumes the existence of glycerophosphoric acid in the molecule of cephalin. Thudichum,1 who discovered cephalin, also was the first to make this assumption. Every other worker who followed Thudichum made similar assumptions. Parnas was the first to call attention to the lack of evidence in favor of the theory, though admitting the possibility of its correctness. MacLean in his monograph on "Lecithin and allied substances" presents a very lucid summary of the weak points of the theory. The main objection to the conclusions of the older writers lies in the fact that the material employed by them was not a pure cephalin but a mixture of this substance with lecithin. In recent years, Frankel and Dimitz3 claimed to have identified glycerophosphoric acid as a component of cephalin. Unfortunately the evidence presented by these investigators is not convincing since they have failed to substantiate their claim with satisfactory analyt 1 Thudichum, J. L. W., The chemical constitution of the brain, London, 1884. 1 Parnas, J., Biochem. Z., 1909, xxii, 411. 'Frankel, S., and Dimitz, L., Biochem. Z., more

Product details

  • Paperback | 188 pages
  • 189 x 246 x 10mm | 345g
  • United States
  • English
  • black & white illustrations
  • 1236971507
  • 9781236971500