Studies from the Rockefeller Institute for Medical Research Volume 33

Studies from the Rockefeller Institute for Medical Research Volume 33

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This historic book may have numerous typos and missing text. Purchasers can usually download a free scanned copy of the original book (without typos) from the publisher. Not indexed. Not illustrated. 1920 edition. Excerpt: ...washings. Our tests, as will appear, were carried out with tissues and with quantities that should have sufficed for infection had the virus been present in amounts to be expected and in an active state. 17 Flexner, S., Clark, P. F., and Fraser, F. R., /. Am. Med. Assn., 1913, lx, 201. 18 Kling, C, and Pettersson, A., Deutsch. med. Woch., 1914, xl, 320. 19 Taylor, E., and Amoss, H. L., /. Exp. Med., 1917, xxvi, 745. The last considerations are pertinent because of the striking contrast in the results obtained with human tissues removed either by operation or post mortem. The obvious deduction is to the effect that the upper respiratory mucosa carries far more active virus in the latter instance. All the postmortem tissues inoculated by us were derived from acute cases. Analogy with other acute infections leads to the assumption that in the fatal instances there is more active multiplication of the virus than in cases which go on to recovery. This is perhaps the simplest interpretation to put upon our tests. The discrepancy seems to illuminate the question as to the time of maximum infectivity in epidemic poliomyelitis. As far as observations made during the great epidemic, which prevailed in New York State and elsewhere in 1916, can be construed, the implication is to the effect that this period is relatively brief and is greatest early in the disease. It cannot be said, however, that this point is definitely established. As a matter of fact, the literature contains records which directly controvert this idea. The matter is perhaps one not to be settled absolutely but rather to be placed on a relative basis. What we need first to know are the conditions under which the virus of poliomyelitis can be definitely determined to be present more

Product details

  • Paperback
  • 189 x 246 x 8mm | 290g
  • United States
  • English
  • black & white illustrations
  • 1236898419
  • 9781236898418