Studies from the Rockefeller Institute for Medical Research Volume 26

Studies from the Rockefeller Institute for Medical Research Volume 26

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This historic book may have numerous typos and missing text. Purchasers can usually download a free scanned copy of the original book (without typos) from the publisher. Not indexed. Not illustrated. 1917 edition. Excerpt: ... it was of short duration, had no marked disturbing influence on the curve representing the cicatrization of the wound. As soon as normal conditions were reestablished, the progress of cicatrization was hastened (Textfig. 9). After a period of inactivity an automatic mechanism seemed to accelerate the healing process. This explains why short periods of infection did not produce marked irregularities in the curve of cicatrization. Again, a period of greater activity was generally followed by a period of slow repair which reestablished the regularity of the curve. In all the experiments cicatrization was more rapid at the beginning than at the end of the period of repair. At the beginning of the process of contraction, the curve inclined rapidly downwards (Textfig. 7), then the inclination diminished and finally the curve became almost horizontal. The greater activity of the beginning of the granulating period has already been observed. It was generally attributed to the aging of the wound. In previous experiments1 we found that during the period of contraction, a wound 60 to 70 mm. wide diminished from 9 to 10 mm. in 24 hours. When it was not more than 20 mm. wide the velocity of cicatrization decreased markedly and became very slight when the edges of the wound were located at a distance of only 10 to 12 mm. from each other. In recent experiments the variations of the size of a wound and not only of one of its dimensions were examined. The absolute value of the rate of cicatrization, that is, the surface lost by the wound in 24 hours, depended mainly on the size of the wound. Wounds of from 120 to 150 sq. cm. decreased from 4 to 7 sq. cm. in 24 hours, while the daily diminution of wounds from 10 to 20 sq. cm. was but 1 to 2 sq. cm. more

Product details

  • Paperback | 166 pages
  • 189 x 246 x 9mm | 308g
  • United States
  • English
  • black & white illustrations
  • 1236811739
  • 9781236811738