Studies from the Rockefeller Institute for Medical Research Volume 20

Studies from the Rockefeller Institute for Medical Research Volume 20

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This historic book may have numerous typos and missing text. Purchasers can usually download a free scanned copy of the original book (without typos) from the publisher. Not indexed. Not illustrated. 1915 edition. Excerpt: ...showed no tendency to gelatinize. The acid in this solution was easily transformed into the crystalline brucine salt and was analyzed as such. The brucine salt was then transformed into the neutral barium salt and this again analyzed. The analysis of the two last named salts permitted us to formulate the composition of guanylic acid as C10H14N5O8P or as a mononucleotide. As a polynucleotide is formed through the process of anhydride formation, the polynucleotide hypothesis of the structure of guanylic acid requires values of carbon, nitrogen and phosphorus higher than those actually found. On the basis of this the following constitution may be ascribed to guanylic acid: /OH P_OH SO HO H O I HOH.C--C--C--C--C--CHN.O H H H / O The substance is optically active, showing a" =--1.270 in hydrochloric acid solution. There is some basis for the assumption that the structure of guanylic acid is not identical with that of inosinic acid. There apparently exists a difference in the union between phosphoric acid and the carbohydrate in these acids analogous to the difference in the union between phosphoric acid and the nucleosides of the two more complex acids, namely, that of the thymus and of the yeast nucleic acid. Both guanylic and yeast nucleic acid permit the detaching of phosphoric acid quite readily, whereas in the inosinic and in the thymus nucleic acid the same reaction is accomplished with great difficulty. This difference is probably due to a difference in the position of the phosphoric acid on the sugar. When hydrolyzed under the same conditions employed for the preparation of ribose phosphoric acid from inosinic acid, the phosphoric acid was completely cleaved from guanylic acid. We have, therefore, as yet been unable to obtain...
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Product details

  • Paperback | 210 pages
  • 189 x 246 x 11mm | 386g
  • United States
  • English
  • black & white illustrations
  • 1236778693
  • 9781236778697