Studies; Reprints Volume 20

Studies; Reprints Volume 20

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This historic book may have numerous typos and missing text. Purchasers can usually download a free scanned copy of the original book (without typos) from the publisher. Not indexed. Not illustrated. 1915 edition. Excerpt: ...the amino-acids are fixed in a loose molecular combination by the proteins, as water of crystallization is held by salts, or as, according to Pfeiffer's recent results, the aminoacids themselves combine with neutral salts such as sodium and calcium chlorides.37 A second possible explanation which is not yet ruled out by the facts is that of purely physical adsorption, the amino-acids being attracted to the colloids of the tissues by forces of surface tension or molecular attraction, such as enable charcoal or cloth fibers to adsorb dyes. We shall, however, leave the solution of this phase of the problem to the future, and merely use the term "absorption" to designate the phenomenon. SUMMARY. The disappearance of intravenously injected amino-acids from the circulation is the result of neither their destruction, synthesis, nor chemical incorporation into the cell proteins. The acids are merely absorbed from the blood by the tissues, without undergoing any immediate chemical change. In the case of the muscles at least, a fairly definite saturation point exists, which sets the limit to the amount of amino-acids that can be absorbed. We have never been able to force the amino nitrogen figure of the striated muscles above 75--80 mg. per 100 grams. The capacity of the internal organs is more elastic; we have raised the amino figure of the liver to 125150 mg. The absorption of amino-acids from the circulation by the tissues, although extremely rapid, is never complete; the blood contains 3-8 mg. of amino-acid nitrogen per 100 cc. even after a fast of several days' duration. The amino-acids of the blood appear, therefore, to be in equilibrium with those of the tissues, a condition which accounts for all the observed...
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Product details

  • Paperback | 198 pages
  • 189 x 246 x 11mm | 363g
  • United States
  • English
  • black & white illustrations
  • 1236758978
  • 9781236758972