Streptomyces in Nature and Medicine

Streptomyces in Nature and Medicine : The Antibiotic Makers

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Description

This is an insider's account of 50 years of genetic studies of the soil-inhabiting microbes that produce most of the antibiotics used to treat infections, as well as anti-cancer, anti-parasitic and immunosuppressant drugs. The book begins by describing how these microbes - the actinomycetes - were discovered in the latter part of the nineteenth century, but remained a 'Cinderella' group until, in the 1940s, they shot to prominence with the discovery of streptomycin, the first effective treatment for tuberculosis and only the second antibiotic after penicillin to become a medical marvel. There followed a massive effort over several decades to find further treatments for infectious diseases and cancer, tempered by the rise of antibiotic resistance consequent on antibiotic misuse and over-use. The book goes on to describe the discovery of gene exchange in the actinomycetes in the context of the rise of microbial genetics in the mid-20th century, leading to determination of the complete DNA sequence of a model member of the group at the turn of the millennium. There follow chapters in which the intricate molecular machinery that adapts the organisms' metabolism and development to life in the soil, including antibiotic production, is illuminated by the DNA blueprint. Then comes an up-to-the minute account of the use of genetic engineering to make novel, hybrid antibiotics and a topical description of techniques to learn the roles of the thousands of genes in a genome sequence, throwing a powerful light on the biology of the organisms and their harnessing for increasing antibiotic prductivity. In the final chapter we return to the mycobacteria that cause tuberculosis and leprosy, the first actinomycetes to be discovered, and how methodology, in part derived from the study of the streptomycetes, is being applied to understand and control these still deadly pathogens.show more

Product details

  • Hardback | 272 pages
  • 160 x 236 x 22mm | 598.75g
  • Oxford University Press Inc
  • New York, United States
  • English
  • New.
  • 50 halftones, line drawings
  • 019515066X
  • 9780195150667
  • 1,642,645

Review quote

Overall this is an extremely well-written book, with a clear and concise narrative that is immensely readable. I would highly recommend it to anyone with an interest in the history of bacteriology, microbial genetics or antibiotics. * Microbiology Today * ...very accessible to the non-specialist reader. New concepts are fully introduced and explained clearly. The book has many black and white illustrations which efficiently aid understanding of the concepts presented...enormously enjoyable. * Immunology News * This work will be welcomed by scientists with an interest in the development of antibiotic microbiology and genetics. * Journal of the History of Medicine *show more

Table of contents

1. Actinomycetes and Antibiotics ; 2. Antibiotic Discovery and Resistance ; 3. Microbial Sex ; 4. Toward Gene Cloning ; 5. From Chromosome Map to DNA Sequence ; 6. Bacteria That Develop ; 7. The Switch to Antibiotic Production ; 8. Unnatural Natural Products ; 9. Functional Genomics ; 10. Genomics Against Tuberculosis and Leprosyshow more

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