Stem Cells and Human Diseases

Stem Cells and Human Diseases

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The main objective of this book is to provide a comprehensive review on stem cells and their role in tissue regeneration, homeostasis and therapy. In addition, the role of cancer stem cells in cancer initiation, progression and drug resistance are discussed. The cell signaling pathways and microRNA regulating stem cell self-renewal, tissue homeostasis and drug resistance are also mentioned. Overall, these reviews will provide a new understanding of the influence of stem cells in tissue regeneration, disease regulation, therapy and drug resistance in several human diseases.
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Product details

  • Paperback | 630 pages
  • 155 x 235 x 32.77mm | 967g
  • Dordrecht, Netherlands
  • English
  • 2012 ed.
  • 20 Tables, black and white; X, 630 p.
  • 940178471X
  • 9789401784719

Back cover copy

There have been major advances in understanding the behavior of stem cells and their roles in tissue regeneration, homeostasis and therapy. Cancer stem cell hypothesis opened a new opportunity for treating and preventing cancers by targeting cancer stem cells or cancer initiating cells. An increased understanding of stem cell behavior and biology along with rapid advancement of high throughput screening has led to the discovery and development of novel drugs that control stem cell self-renewal and differentiation. In near future, these molecules will be very useful for treating and preventing several human diseases.

While progress on the clinical front has been slower than desired, the use of stem cells for tissue regeneration and disease management has great potential in human health.

The first decade of the 21st century has brought with it significant progress in our understanding of stem cell or progenitor cells and their role in tissue regeneration and management of human diseases including cancer, neurodegenerative disorders, and heart diseases. This book covers the current state-of-the-art knowledge on the role of stem cells in tissue regeneration, homeostasis and disease management.


Coverage of the biology of stem cell and their role in tissue regeneration and organogenesis.Mechanism-based strategies for stem cell self-renewal and differentiation.Role of cancer stem cells or tumor initiating cells in cancer initiation, progression, relapse and drug resistance.Use of stem cells in treating several human diseases, such as Alzheimer's disease, Parkinson's disease, cancer and diabetes.
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Table of contents

Cancer Stem Cells: Biology, Perspectives and Therapeutic Implications; Brahma N. Singh, Sharmila Shankar and Rakesh K. Srivastava
The Perspectives of Stem Cell-based Therapy in Neurological Diseases; Wojciech Maksymowicz, Joanna Wojtkiewicz, Hanna Kozlowska, Aleksandra Habich and Wlodek Lopaczynski
Stem Cell-based Therapy for Lysosomal Storage Diseases; Brittni A. Scruggs, Xiujuan Zhang, Jeffrey M. Gimble and Bruce A. Bunnell
Drosophila germline stem cells; Yalan Xing and Willis X. Li
Mesenchymal Stem Cells in Hematopoietic Stem Cell Transplantation; Peiman Hematti, Jaehyup Kim and Minoo Battiwalla
Cancer Stem Cells in Solid Tumors, Markers and Therapy; Ortiz-Sanchez Elizabeth, Gonzalez-Montoya Jose Luis, Langley Elizabeth and Garcia-Carranca Alejandro
Cancer Stem Cells: Paradigm Shifting or Perishing Concept?; Senthil K Pazhanisamy and Keith Syson Chan
Genomics of Prostate Cancer; Kern Rei Chng, Shin Chet Chuah, Edwin Cheung
Ischemia, reactive radicals, redox signaling and hematopoietic stem cells; Suman Kanji, Vincent J. Pompili and Hiranmoy Das
Cancer stem cell models and role in drug discovery; Rohit Duggal, Boris Minev, Angelo Vescovi and Aladar Szalay
Origins of Metastasis-Initiating Cells; Sara M. Nolte and Sheila K. Singh
The Reduction of Callus Formation during Bone Regeneration by BMP-2 and Human Adipose Derived Stem Cells; Claudia Keibl and Martijn van Griensven
Stem cells and leukemia; Vincenzo Giambra and Christopher R. Jenkins
The role of adult bone marrow derived mesenchymal stem cells, growth factors and scaffolds in the repair of cartilage and bone; Antal Salamon and Erzsebet Toldy
Worth the Weight: Adipose Stem Cells in Human Disease; Saleh Heneidi and Gregorio Chazenbalk
Neural crest and Hirschsprung's disease; Kim Hei-Man CHOW , Paul Kwong-Hang TAM, Elly Sau-Wai NGAN
Common denominators of self-renewal and malignancy IN neural stem cells and GLIOMA; Grzegorz Wicher, Karin Holmqvist and Karin Forsberg-Nilsson
Stem-like cells from brain tumours or vice versa?; Sara G.M. Piccirillo
Translating Mammary Stem Cell and Cancer Stem Cell Biology to the Clinics; Rajneesh Pathania, Vadivel Ganapathy and Muthusamy Thangaraju
Breast Cancer Stem Cells; Shane R. Stecklein and Roy A. Jensen
Translin/TRAX deficiency affects mesenchymal differentiation programs and induces bone marrow failure; Reiko Ishida, Katsunori Aoki, Kazuhiko Nakahara, Yuko Fukuda, Momoko Ohhori, Yumi Saito, Kimihiko Kano, Junichiro Matsuda, Shigetaka Asano, Richard T. Maziarz and Masataka Kasai
Cancer therapies and Stem cells; Hiromichi Kimura
Cancer Stem Cells and Head and Neck Squamous Cell Carcinomas; Shi-Long Lu
The Biology of Lung Cancer Stem Cells; Sandeep Singh and Srikumar P. Chellappan
Stem Cell Characters in Primary and Metastatic Tumour Establishment; Maria Tsekrekou, Dimitris Mavroudis, Dimitris Kafetzopoulos, Despoina Vassou
Plasticity of Cancer Stem Cells; Zhizhong Li
Cross talks among Notch, Wnt, and Hedgehog signaling pathways regulate stem cell characteristics; Su-Ni Tang, Sharmila Shankar, and Rakesh K. Srivastava
Global OMICs profiling and functional analysis of CD44+/CD24- stem-like cells in normal human breast tissue and breast cancer; Marina Bessarabova, Kornelia Polyak, Yuri Nikolsky
Breast Cancer Stem Cells: Isolation, characterization and targeting; Anurag N. Paranjape
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