Stem Cell Transplantation for Hematologic disorders

Stem Cell Transplantation for Hematologic disorders

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Description

This is a comprehensive survey of the current state-of-the-art in hematopoietic stem cell transplantation for malignant disease. The authors focus on the indications and results of transplantation for acute leukemia, chronic myelogenous leukemia, lymphoma, multiple myeloma, and breast cancer. Special attention is given to transplant-related complications, including the pathophysiology and clinical consequences of acute and chronic GVHD, delayed immune reconstitution leading to infectious complications, and organ damage to the lung and liver. Additional chapters address the sources of stem cells and the effects of graft manipulation used to eliminate residual contaminating tumor cells in autologous transplantation, or to reduce the number of T lymphocytes causing GVHD in allogenic transplantation.show more

Product details

  • Hardback | 504 pages
  • 180.8 x 260.1 x 33.5mm | 1,270.07g
  • Humana Press Inc.
  • Totowa, NJ, United States
  • English
  • New.
  • 0
  • 1588291804
  • 9781588291806

Review quote

Current transplant approaches to the individual hematologic malignancies are discussed and the literature critiqued. The diverse complications of transplantation are discussed in considerable detail; the authors clearly define the underlying pathophysiology as well as state-of-the-art treatment approaches. Chapters on the new field of alternative graft sources is one of the book's best features and include unrelated, haploidentical and umbilical cord transplantation. This is a high-quality publication that is easy to read and not as overwhelming as the larger, more comprehensive transplant books. It is full of helpful information and references. - Doody's Health Sciences Book Review Journal This book provides a timely update and a valuable summary of this rapidly evolving field. - Annals of Internal Medicineshow more

Table of contents

Part I. Transplant for Malignant Disease Allogeneic and Autologous Stem Cell Transplantation for Acute Leukemia and Myelodysplasia in the Adult Sandra Cohen and Stephen J. Forman Hematopoietic Stem Cell Transplantation for Chronic Myelogenous Leukemia Humberto Caldera and Sergio Giralt Stem Cell Transplantation for Hodgkin's and Non-Hodgkin's Lymphomas Thomas J. Kenney and John W. Sweetenham Autologous and Allogeneic Transplantation for Multiple Myeloma Faith E. Davies and Kenneth C. Anderson Hematopoietic Progenitor Cell Transplantation for Breast Cancer Yago Nieto and Elizabeth J. Shpall Part II. Complications of Transplantation Pathophysiology of Acute Graft-vs-Host Disease Takanori Teshima and James L. M. Ferrara Acute Graft-vs-Host Disease Uwe Platzbecker and H. Joachim Deeg Chronic Graft-vs-Host Disease After Transplantation Georgia B. Vogelsang and Colleen H. McDonough Immune Reconstitution After Allogeneic Transplantation Carolyn A. Keever-Taylor Infection in the Hematopoietic Stem Cell Transplant Recipient Lindsey Baden and Robert H. Rubin EBV Lymphoproliferative Disease After Transplantation Stephen Gottschalk, Cliona M. Rooney, and Helen E. Heslop Pathophysiology of Lung Injury After Hematopoietic Stem Cell Transplantation Kenneth R. Cooke Hepatic Veno-Occlusive Disease Paul G. Richardson Quality-of-Life Issues Posttransplantation Stephanie J. Lee Part III. Sources of Donor Stem Cells Stem Cell Sources: Peripheral Blood Stem Cells and Bone Marrow for Allogeneic Transplantation Corey Cutler and Joseph H. Antin Allogeneic Unrelated Donor Blood and Marrow Transplantation Daniel Weisdorf Haploidentical Stem Cell Transplantation P. Jean Henslee-Downey Umbilical Cord Hematopoietic Stem Cell Transplantation Timothy F. Goggins and Nelson J. Chao Part IV. Graft Engineering Tumor Contamination of Stem Cell Products: The Role of Purging John G. Gribben T-Cell Depletion to Prevent Graft-vs-Host Disease Vincent Ho and Robert J. Soiffer Part V. Graft-vs-Tumor Effect Donor Lymphocyte Infusions: Clinical Applications and the Graft-vs-Leukemia Effect Edwin P. Alyea III Nonmyeloablative Transplantation Lyle C. Feinstein and Brenda M. Sandmaier Indexshow more