The Somatotrophic Axis in Brain Function

The Somatotrophic Axis in Brain Function

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The somatotropic axis is one of the major hormonal systems regulating postnatal growth in mammals. It interacts with the central nervous system on several levels. Growth hormone (GH) and insulin-like growth factor-I (IGF-I) receptors are expressed in many brain areas including the hippocampus, pituitary and hypothalamus. GH and IGF-I are important factors in the development and differentiation of the CNS and have protective properties in dementia, as well as in traumatic and ischaemic injury of the CNS. Also GH has an important impact on mood and well-being with GH secretory capacity being reduced in depression.

This volume will include chapters (1) on basic knowledge on GH/IGF-1, (2) on localization of GH/IGF-1 and their receptors in the CNS, including blood brain barrier transport of both hormones, (3) on actions of the two hormones on CNS function (basic science), (4) on clinical aspects of GH/IGF-1 in relation to various CNS functions and disorders, and finally (5) on some future perspectives in this area of science.
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Product details

  • Hardback | 384 pages
  • 218.4 x 279.4 x 22.9mm | 1,111.31g
  • Academic Press Inc
  • San Diego, United States
  • English
  • Illustrated; Illustrations, unspecified
  • 0120884844
  • 9780120884841

Review quote

"Because of its breadth, this book will be a useful resource for both research scientists and clinicians. For the established scientist, the chapters provide a good brush-up and ready source of references; whereas for the new clinician or scientist entering the GH-CNS field, it will provide a strong and broad introduction to the field and a fairly comprehensive basis to build upon."
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Table of contents

Section 1: Biosynthesis of Growth Hormone and Insulin-like Growth Factor-I and Regulation of Their Secretion


Chapter 1: Regulation and Mechanism of Growth Hormone and Insulin-like Growth Factor-I Biosynthesis and Secretion

Chapter 2: Ghrelin, an Endogenous Ligand for the Growth Hormone Secretagogue Receptor

Section 2: Growth Hormone and Insulin-like Growth Factor-I and their Function at the Receptor Level

Chapter 3: Mechanisms of Signal Transduction Utilized by Growth Hormone

Chapter 4: Insulin-like Growth Factor-I and Its Binding Proteins: Regulation of Secretion and Mechanism of Action at the Receptor Level

Section 3: Growth Hormone and Insulin-like Growth Factors and Their Receptors in the Central Nervous System

Chapter 5: Growth Hormone and Insulin-like Growth Factor-I in Human Cerebrospinal Fluid

Chapter 6: Growth Hormone, Insulin, and Insulin-like Growth Factor-I: Do They Interact at the Blood-Brain Barrier?

Chapter 7: Growth Hormone and Insulin-like Growth Factors in the Central Nervous System: Localization in Mammalian Species

Chapter 8: Purification of Growth Hormone Receptors from Human Brain Tissues

Chapter 9: Growth Hormone Receptor Message in the Rat and Human Central Nervous System: Structure and Function

Section 4: Central Nervous System Action of Growth Hormone: Basic Studies Using Animal Models

Chapter 10: Interaction of Growth Hormone and Prolactin in Brain Circuits

Chapter 11: Growth Hormone and Insulin-like Growth Factor-I and Cellular Regeneration in the Adult Brain

Chapter 12: Growth Hormone and Insulin-like Growth Factor-I and Their Effects on Astroglial Gap Junctions

Chapter 13: Rodent Models for the Study of the Role of Growth Hormone-Insulin-like Growth Factor-I or the Insulin Axis in Aging and Longevity: Special Reference to a Transgenic Dwarf Rat Strain and Calorie Restriction

Chapter 14: Growth Hormone and Insulin-like Growth Factor-I and Their Interactions with Brain Circuits Involved in Cognitive Function

Chapter 15: Insulin-like Growth Factor-I and Neuroprotection

Section 5: Immediate and Long-Term Benefits on the Central Nervous System and Growth Hormone Replacement Therapy

Chapter 16: Quality of Life in Adult Growth Hormone Deficiency

Chapter 17: The Somatotropic Axis in Psychologic Functioning: Effects on Sleep and Psychopathology

Chapter 18: Growth Hormone Replacement Therapy in Adults: Responsiveness Related to Life Quality

Chapter 19: Psychological Importance to the Child of Growth Hormone Replacement

Chapter 20: Acromegaly and Brain Function: Effects on the Human Brain during Conditions with Increased Growth Hormone Concentrations

Chapter 21: Human Aging and the Growth Hormone/Insulin-like Growth Factor-I Axis: The Impact of Growth Factors on Dementia

Chapter 22: Cognitive Status of Adult Growth Hormone (GH)-Deficient Patients and GH-Induced Neuropsychological Changes

Chapter 23: Growth Hormone and Insulin-like Growth Factor-I in Alzheimer's Disease

Section 6: Growth Hormone Replacement and Related Therapies in Central Nervous System Disorders: A Future Perspective

Chapter 24: Growth Hormone Antagonists: A Pharmacological Tool in Present and Future Therapies

Chapter 25: Growth Hormone Replacement Therapy and Life Quality: Future Perspectives

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