Snake Venoms; An Investigation of Venomous Snakes with Special Reference to the Phenomena of Their Venoms
This historic book may have numerous typos and missing text. Purchasers can usually download a free scanned copy of the original book (without typos) from the publisher. Not indexed. Not illustrated. 1909 edition. Excerpt: ...chapter, obtained somewhat different results in regard to a few facts. Thus, in speaking of the simultaneous action of an anticoagulating and a coagulation-inducing venom, he states that the action of each opposite-acting venom is entirely lost by their being mixed together. 0.00: gm. of lachesis venom can coagulate r c.c. of citrate plasma of rabbit in 1 minute. But if 0.001 gm. of the venom of Cobra or of water-moccasin is previously added to the plasma and then 0.00: gm. of lachesis venom, no coagulation takes place. Such incoagulate mixture clots perfectly if r c.c. of a 0.5 per cent solution of calcium chloride is added. It was also stated by Calmette that even the most procoagulating venoms prevent coagulation of the blood in vilro when a sufficiently large quantity of these venoms is employed. For example, 0.004 gm. of lachesis venom and 0.007 gm. of daboia venom prevent coagulation of citrate plasma of rabbit. This phenomenon was explained by the theory that these viperine venoms display a powerful proteolytic action upon coagulated or dissolved fibrin. He refers also to the fact that even with a weaker coagulating dose the proteolytic action is manifest, for the coagulum once formed is gradually softened and finally dissolved, as is usually seen in an experiment with a cube of eggalbumin in a typtic digestion. In regard to the anticoagulating property of cobra venom and colubrine venom in general, Calmette states that it is due to destruction of the fibrin ferment by the venom, whereas the viperine venoms are said to attack chiefly fibrin itself. CHAPTER XIV. NEUROTOXINS OF SNAKE VENOM. Through the exhaustive investigations of early physiologists and pathologists, notably of S. Weir Mitchell, Reichert, F ayrer, Brunton, Wall, ..
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- 13 Sep 2013
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