The Skeleton
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The Skeleton : Biochemical, Genetic, and Molecular Interactions in Development and Homeostasis

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Description

This book gives a cutting-edge review of the biochemical, physiological, pharmacological, genetic, and molecular interactions involved in the development and homeostasis of the skeleton. The topics range from chondrogenesis, chondrocytes, and cartilage to skeletal dysmorphology, and include the control of skeletal development, osteoblastic cell differentiation, and bone induction, growth, remodeling, and mineralization. The authors' understanding of bone physiology - and how it is modified throughout all the stages of life - offers novel approaches for improving the endurance of load-bearing implants, achieving life-long optimal bone strength, overcoming microgravity situations (space flight), and hastening the healing of fractures, osteotomies, and antrodeses.show more

Product details

  • Hardback | 428 pages
  • 183.9 x 260.1 x 27.4mm | 1,093.17g
  • Humana Press Inc.
  • Totowa, NJ, United States
  • English
  • 2004 ed.
  • biography
  • 1588292150
  • 9781588292155

Review quote

"...a valuable book...Every substantial biomedical library should have this book." -Doody's Health Sciences Book Review Journal "Very detailed, clinical and laden with biological terminology, which makes the preface a must for new readers." -E-STREAMS "Authoritative and up-to-date... a cutting-edge survey of diverse critical issues in bone biology." - Clinical Laboratory Internationalshow more

Back cover copy

The skeleton is a complex multifunctional system. In addition to its mechanical/structural support function, it is, as the major reservoir of calcium, intimately involved in intracellular signaling pathways of critical importance both in the complex process of development and the maintenance of physiologic homeostasis. It is also, as the major source of blood cells, a critical part of the circulatory, respiratory, and immune systems. In The Skeleton: Biochemical, Genetic, and Molecular Interactions in Development and Homeostasis, established biomedical researchers, developmental biologists, and clinical practitioners offer a cutting-edge survey of diverse critical issues in bone biology. Topics range from chondrogenesis, chondrocytes, and cartilage to skeletal dysmorphology, and include the control of skeletal development, osteoblastic cell differentiation, and bone induction, growth, remodeling, and mineralization. The authors focus on the biochemical, genetic, and molecular interactions that support the development and homeostasis of the skeleton. Their state-of-the-art understanding of bone physiology-and how it is modified throughout all the stages of life-offers novel approaches for improving the endurance of load-bearing implants, achieving life-long optimal bone strength, overcoming microgravity (space flight), and hastening the healing of fractures, osteotomies, and arthrodeses. Equally important are their insights into metaphyseal fractures in the aged, into the mechanism(s) of osteopenia and osteoporosis, and into how and why, during menopause, healthy women lose only bone adjacent to the marrow. Authoritative and up-to-date, The Skeleton: Biochemical, Genetic, and Molecular Interactions in Development and Homeostasis offers biomedical and clinical researchers rapid access to the latest understanding of the biochemistry, physiology, pharmacology, genetics, molecular biology, developmental biology, and aging of the skeleton.show more

Table of contents

I. Chondrogenesis, Chondrocytes, and Cartilage Molecular Basis of Cell-Cell Interaction and Signaling in Mesenchymal Chondrogenesis Rocky S. Tuan Chondrocyte Cell Fate Determination in Response to Bone Morphogenetic Protein Signaling Lillian Shum, Yuji Hatakeyama, Julius Leyton, and Kazuaki Nonaka Regulation of Chondrocyte Differentiation Andreia M. Ionescu, M. Hicham Drissi, and Regis J. O'Keefe Continuous Expression of Cbfa1 in Nonhypertrophic Chondrocytes Uncovers Its Ability to Induce Hypertrophic Chondrocyte Differentiation and Partially Rescues Cbfa1-Deficient Mice Shu Takeda, Jean-Pierre Bonnamy, Michael J. Owen, Patricia Ducy, and Gerard Karsenty Molecular Biology and Biosynthesis of Collagens Johanna Myllyharju Mechanotransduction Pathways in Cartilage Qian Chen II. Control of Skeletal Development Molecular Genetic Analysis of the Role of the HoxD Complex in Skeletal Development: Impact of the loxP/Cre System in Targeted Mutagenesis of the Mouse HoxD Complex Marie Kmita, Denis Duboule, and Jozsef Zakany Control of Development and Homeostasis Via Regulation of BMP, Wnt, and Hedgehog Signaling Renee Hackenmiller, Catherine Degnin, and Jan Christian FGF4 and Skeletal Morphogenesis Valerie Ngo-Muller, Shaoguang Li, Scott A. Schaller, Manjong Han, Jennifer Farrington, Minoru Omi, Rosalie Anderson, and Ken Muneoka Retinoid Signaling and Skeletal Development Andrea D. Weston and T. Michael Underhill Retinoids and Indian Hedgehog Orchestrate Long Bone Development Maurizio Pacifici, Chiara Gentili, Eleanor Golden, and Eiki Koyama III. Osteoblastic Cell Differentiation Synergy Between Osteogenic Protein-1 and Osteotropic Factors in the Stimulation of Rat Osteoblastic Cell Differentiation John C. Lee and Lee-Chuan C. Yeh Bone MorphogenicProteins, Osteoblast Differentiation, and Cell Survival During Osteogenesis Cun-Yu Wang Osteoclast Differentiation Sakamuri V. Reddy and G. David Roodman IV. Bone Induction, Growth, and Remodeling Soluble Signals and Insoluble Substrata: Novel Molecular Cues Instructing the Induction of Bone Ugo Ripamonti, Nathaniel L. Ramoshebi, Janet Patton, Thato Matsaba, June Teare, and Louise Renton Perichondrial and Periosteal Regulation of Endochondral Growth Dana L. Di Nino and Thomas F. Linsenmayer Computer Simulations of Cancellous Bone Remodeling Jacqueline C. van der Linden, Harrie Weinans, and Jan A. N. Verhaar Effects of Microgravity on Skeletal Remodeling and Bone Cells Pierre J. Marie V. Bone Mineralization Quantitative Analyses of the Development of Different Hard Tissues Siegfried Arnold, Hans J. Hohling, and Ulrich Plate Fetal Mineral Homeostasis and Skeletal Mineralization Christopher S. Kovacs Control of Osteoblast Function and Bone Extracellular Matrix Mineralization by Vitamin D Johannes P. T. M. van Leeuwen, Marjolein van Driel, and Hulbert A. P. Pols VI. Skeletal Dysmorphology Role of Pax3 and PDGF-a Receptor in Skeletal Morphogenesis and Facial Clefting Simon J. Conway Genetics of Achondroplasia and Hypochondroplasia Giedre Grigelioniene Effects of Boric Acid on Hox Gene Expression and the Axial Skeleton in the Developing Rat Michael G. Narotsky, Nathalie Wery, Bonnie T. Hamby, Deborah S. Best, Nathalie Pacico, Jacques J. Picard, Francoise Gofflot, and Robert J. Kavlock Toxicant-Induced Lumbar and Cervical Ribs in Rodents John M. Rogers, R. Woodrow Setzer, and Neil Chernoff Experimental Skeletal Dysmorphology: Risk Assessment Issues Rochelle W. Tyl, Melissa C. Marr, and Christina B. Myers Indexshow more