The Skeleton

The Skeleton : Biochemical, Genetic, and Molecular Interactions in Development and Homeostasis

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A cutting-edge review of the biochemical, physiological, pharmacological, genetic, and molecular interactions involved in the development and homeostasis of the skeleton. Topics range from chondrogenesis, chondrocytes, and cartilage to skeletal dysmorphology, and include the control of skeletal development, osteoblastic cell differentiation, and bone induction, growth, remodeling, and mineralization. The authors' understanding of bone physiology-and how it is modified throughout all the stages of life-offers novel approaches for improving the endurance of load-bearing implants, achieving life-long optimal bone strength, overcoming microgravity situations (space flight), and hastening the healing of fractures, osteotomies, and antrodeses.
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Product details

  • Hardback | 428 pages
  • 183.9 x 260.1 x 27.4mm | 1,093.17g
  • Totowa, NJ, United States
  • English
  • 2004 ed.
  • XVIII, 428 p.
  • 1588292150
  • 9781588292155

Back cover copy

The skeleton is a complex multifunctional system. In addition to its mechanical/structural support function, it is, as the major reservoir of calcium, intimately involved in intracellular signaling pathways of critical importance both in the complex process of development and the maintenance of physiologic homeostasis. It is also, as the major source of blood cells, a critical part of the circulatory, respiratory, and immune systems. In The Skeleton: Biochemical, Genetic, and Molecular Interactions in Development and Homeostasis, established biomedical researchers, developmental biologists, and clinical practitioners offer a cutting-edge survey of diverse critical issues in bone biology. Topics range from chondrogenesis, chondrocytes, and cartilage to skeletal dysmorphology, and include the control of skeletal development, osteoblastic cell differentiation, and bone induction, growth, remodeling, and mineralization. The authors focus on the biochemical, genetic, and molecular interactions that support the development and homeostasis of the skeleton. Their state-of-the-art understanding of bone physiology-and how it is modified throughout all the stages of life-offers novel approaches for improving the endurance of load-bearing implants, achieving life-long optimal bone strength, overcoming microgravity (space flight), and hastening the healing of fractures, osteotomies, and arthrodeses. Equally important are their insights into metaphyseal fractures in the aged, into the mechanism(s) of osteopenia and osteoporosis, and into how and why, during menopause, healthy women lose only bone adjacent to the marrow.
Authoritative and up-to-date, The Skeleton: Biochemical, Genetic, and Molecular Interactions in Development and Homeostasis offers biomedical and clinical researchers rapid access to the latest understanding of the biochemistry, physiology, pharmacology, genetics, molecular biology, developmental biology, and aging of the skeleton.
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Table of contents

I. Chondrogenesis, Chondrocytes, and Cartilage

Molecular Basis of Cell-Cell Interaction and Signaling in Mesenchymal Chondrogenesis
Rocky S. Tuan

Chondrocyte Cell Fate Determination in Response to Bone Morphogenetic Protein Signaling
Lillian Shum, Yuji Hatakeyama, Julius Leyton, and Kazuaki Nonaka

Regulation of Chondrocyte Differentiation
Andreia M. Ionescu, M. Hicham Drissi, and Regis J. O'Keefe

Continuous Expression of Cbfa1 in Nonhypertrophic Chondrocytes Uncovers Its Ability to Induce Hypertrophic Chondrocyte Differentiation and Partially Rescues Cbfa1-Deficient Mice
Shu Takeda, Jean-Pierre Bonnamy, Michael J. Owen, Patricia Ducy, and Gerard Karsenty

Molecular Biology and Biosynthesis of Collagens
Johanna Myllyharju

Mechanotransduction Pathways in Cartilage
Qian Chen

II. Control of Skeletal Development

Molecular Genetic Analysis of the Role of the HoxD Complex in Skeletal Development: Impact of the loxP/Cre System in Targeted Mutagenesis of the Mouse HoxD Complex
Marie Kmita, Denis Duboule, and Jozsef Zakany

Control of Development and Homeostasis Via Regulation of BMP, Wnt, and Hedgehog Signaling
Renee Hackenmiller, Catherine Degnin, and Jan Christian

FGF4 and Skeletal Morphogenesis
Valerie Ngo-Muller, Shaoguang Li, Scott A. Schaller, Manjong Han, Jennifer Farrington, Minoru Omi, Rosalie Anderson, and Ken Muneoka

Retinoid Signaling and Skeletal Development
Andrea D. Weston and T. Michael Underhill

Retinoids and Indian Hedgehog Orchestrate Long Bone Development
Maurizio Pacifici, Chiara Gentili, Eleanor Golden, and Eiki Koyama

III. Osteoblastic Cell Differentiation

Synergy Between Osteogenic Protein-1 and Osteotropic Factors in the Stimulation of Rat Osteoblastic Cell Differentiation
John C. Lee and Lee-Chuan C. Yeh

Bone MorphogenicProteins, Osteoblast Differentiation, and Cell Survival During Osteogenesis
Cun-Yu Wang

Osteoclast Differentiation
Sakamuri V. Reddy and G. David Roodman

IV. Bone Induction, Growth, and Remodeling

Soluble Signals and Insoluble Substrata: Novel Molecular Cues Instructing the Induction of Bone
Ugo Ripamonti, Nathaniel L. Ramoshebi, Janet Patton, Thato Matsaba, June Teare, and Louise Renton

Perichondrial and Periosteal Regulation of Endochondral Growth
Dana L. Di Nino and Thomas F. Linsenmayer

Computer Simulations of Cancellous Bone Remodeling
Jacqueline C. van der Linden, Harrie Weinans, and Jan A. N. Verhaar

Effects of Microgravity on Skeletal Remodeling and Bone Cells
Pierre J. Marie

V. Bone Mineralization

Quantitative Analyses of the Development of Different Hard Tissues
Siegfried Arnold, Hans J. Hoehling, and Ulrich Plate

Fetal Mineral Homeostasis and Skeletal Mineralization
Christopher S. Kovacs

Control of Osteoblast Function and Bone Extracellular Matrix Mineralization by Vitamin D
Johannes P. T. M. van Leeuwen, Marjolein van Driel, and Hulbert A. P. Pols

VI. Skeletal Dysmorphology

Role of Pax3 and PDGF-a Receptor in Skeletal Morphogenesis and Facial Clefting
Simon J. Conway

Genetics of Achondroplasia and Hypochondroplasia
Giedre Grigelioniene

Effects of Boric Acid on Hox Gene Expression and the Axial Skeleton in the Developing Rat
Michael G. Narotsky, Nathalie Wery, Bonnie T. Hamby, Deborah S. Best, Nathalie Pacico, Jacques J. Picard, Francoise Gofflot, and Robert J. Kavlock

Toxicant-Induced Lumbar and Cervical Ribs in Rodents
John M. Rogers, R. Woodrow Setzer, and Neil Chernoff

Experimental Skeletal Dysmorphology: Risk Assessment Issues
Rochelle W. Tyl, Melissa C. Marr, and Christina B. Myers

Index
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Review quote

"...a valuable book...Every substantial biomedical library should have this book." -Doody's Health Sciences Book Review Journal



"Very detailed, clinical and laden with biological terminology, which makes the preface a must for new readers." -E-STREAMS



"Authoritative and up-to-date... a cutting-edge survey of diverse critical issues in bone biology." - Clinical Laboratory International
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