Signal Transduction and the Gasotransmitters

Signal Transduction and the Gasotransmitters : NO, CO, and H2S in Biology and Medicine

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Distinguished researchers and clinicians review the biological and biomedical aspects of gasotransmitters, emphasizing signaling transduction mechanisms in general, and ion channel regulation in particular. The authors discuss the endogeneous metabolism and regulation of gasotransmitters, their toxicological profiles and biological actions, and their interactions in terms of their production and effects. The physiological roles of NO, CO, and H2S in the regulation of the cardiovascular, neuronal, and gastrointestinal systems, as well as of cell metabolism, are also reviewed, along with the interaction of the gastrotransmitters with KATP,KCa voltage-gated Ca2+, voltage-gated Na+, and cyclic nucleotide-gated ion channels.show more

Product details

  • Hardback | 378 pages
  • 182.9 x 256.5 x 30.5mm | 952.56g
  • Humana Press Inc.
  • Totowa, NJ, United States
  • English
  • 2004 ed.
  • XIV, 378 p.
  • 1588293491
  • 9781588293497

Review quote

From the foreword... "...a paradigm-shifting assessment of the new category of transmitters, the gasotransmitters." -Bruce McManus, MD, PhD, FRSC, Canadian Institutes of Health Research "...well-written...the account by Sanada and colleagues is particularly interesting on cardio protection and ischeamic preconditioning...this book should be of interest to both specialist researchers as well as members of the wider scientific commuity." -BTS Newsletters "...an excellent source of references for signal transduction mechanisms underlying he physiological functions of NO, CO, and H2S." - British Journal of Anesthesiologyshow more

Back cover copy

Gasotransmitters-principally nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S)-are endogenous signaling molecules that play a significant role in the biomedical, clinical, and health sciences, as well as in population health studies. In Signal Transduction and the Gasotransmitters: NO, CO, and H2S in Biology and Medicine, a panel of distinguished researchers and clinicians review the biological and biomedical aspects of gasotransmitters, emphasizing their signaling transduction mechanisms in general, and ion channel regulation in particular. The authors discuss the endogeneous metabolism and regulation of gasotransmitters, their toxicological profiles and biological actions, and their interactions in terms of their production and effects. The physiological roles of NO, CO, and H2S in the regulation of the cardiovascular, neuronal, and gastrointestinal systems, as well as of cell metabolism, are also reviewed, along with the interaction of the gastrotransmitters with KATP, KCa voltage-gated Ca2+, voltage-gated Na+, and cyclic nucleotide-gated ion channels. Included in the array of different mechanisms for the interaction of NO, CO, and H2S are channel phosphorylation, S-nitrosylation, carboxylation, sulfuration, and altered cellular redox status. The authors also offer guidance and suggestions for exploring and further characterizing other still unknown gasotransmitters. Authoritative and comprehensive, Signal Transduction and the Gasotransmitters: NO, CO, and H2S in Biology and Medicine offers clinical scientists and physicians not only a deeper understanding, but also a cutting-edge review, of the critically important field of gasotransmitter biology and medicine.show more

Table of contents

Part I. Gasotransmitters: Past, Present, and Future The Evolution of Gasotransmitter Biology and Medicine: From Atmospheric Toxic Gases to Endogenous Gaseous Signaling Molecules Rui Wang Interactions Between Gasotransmitters Ray J. Carson, Gunter Seyffarth, Rubina Mian, and Helen Maddock Part II. The Emergence of the First Gasotransmitter: Nitric Oxide Nitric Oxide: Synthesis and Metabolism, Tissue Stores, and the Relationship of Endothelium-Derived Nitric Oxide to Endothelium-Dependent Hyperpolarization Chris R. Triggle, Hong Ding, Ella S. M. Ng, and Anthie Ellis Chemical Interaction of Nitric Oxide With Protein Thiols: S-Nitrosylation Signaling Allan Doctor and Benjamin M. Gaston Nitric Oxide and Adenosine Triphosphate-Sensitive Potassium Channels: Their Different Properties But Analogous Effects on Cellular Protection Shoji Sanada, Jiyoong Kim, and Masafumi Kitakaze Interactions of Nitric Oxide and Related Radical Species With KCa Channels Yanping Liu and David D. Gutterman Nitric Oxide and Voltage-Gated Ca2+ Channels Claudio Grassi, Marcello D'Ascenzo, and Gian Battista Azzena Interactions of Nitric Oxide and Cardiac Ion Channels Zhao Zhang, Kathryn A. Glatter, and Nipavan Chiamvimonvat S-Nitrosylation of Cyclic Nucleotide-Gated Channels Marie-Christine Broillet Part III. Story of a Silent Killer: The Resurgence of Carbon Monoxide as the Second Gasotransmitter Synthesis and Metabolism of Carbon Monoxide Stefan W. Ryter and Augustine M. K. Choi Interaction of Carbon Monoxide With K+ Channels in Vascular Smooth Muscle Cells Rui Wang Modulation of Multiple Types of Ion Channels by Carbon Monoxide in Nonvascular Tissues and Cells Rui Wang The Molecular Mechanisms Underlying the Effects of Carbon Monoxide on Calcium-Activated K+ Channels Lingyun Wu Carbon Monoxide and Signal Transduction Pathways Patty J. Lee and Leo E. Otterbein Carbon Monoxide-Induced Alterations in the Expression of KCa Channels in Pulmonary Artery Smooth Muscle Cells Eric Dubuis, Prem Kumar, Pierre Bonnet, and Christophe Vandier Part IV. Gas of the Rotten Egg: Hydrogen Sulfide as Another Gasotransmitter Hydrogen Sulfide Production and Metabolism in Mammalian Tissues Kenneth N. Maclean and Jan P. Kraus Toxicological and Environmental Impacts of Hydrogen Sulfide Sheldon H. Roth Hydrogen Sulfide and the Regulation of Neuronal Activities Hideo Kimura The Role of Hydrogen Sulfide as an Endogenous Vasorelaxant Factor Rui Wang, Youqin Cheng, and Lingyun Wu Hydrogen Sulfide and Visceral Smooth Muscle Contractility Philip K. Moore Interaction of Hydrogen Sulfide and Adenosine Triphosphate-Sensitive Potassium Channels in Vascular Smooth Muscle Cells Rui Wang Part V. Gasotransmitters, Other Gaseous Molecules, and Cell Metabolism Gasotransmitters as a Novel Class of Metabolic Regulators: Nitric Oxide, Carbon Monoxide, and Nitrous Oxide Misato Kashiba Indexshow more