Signal Transduction is a well-illustrated, coherent look at cellular signaling processes. Beginning with the basics, it explains how cells respond to external cues, hormones, growth factors, cytokines, cell surfaces, etc., and then shows how these inputs are integrated and coordinated. The extensive color artwork provides the reader with a clearer comprehension of key topics, and margin notes are incorporated to highlight milestones in the evolution of signal transduction. This book serves as an invaluable resource for advanced undergraduates, graduate researchers, and established scientists working in cell biology, pharmacology, immunology, and related fields.
- Hardback | 420 pages
- 190.5 x 248.92 x 30.48mm | 1,428.81g
- 18 Mar 2002
- Elsevier Science Publishing Co Inc
- Academic Press Inc
- San Diego, United States
- colour and b&w illustrations
Table of contents
Prologue: Signal transduction, origins and personalities. First messengers. Receptors. GTP-binding proteins and signal transduction. Effector enzymes coupled to GTP-binding proteins: adenylyl cyclase and phospholipase. The regulation of visual transduction. Calcium and signal transduction. Calcium signalling. Phosphorylation and dephosphorylation:protein kinases A and C. Growth Factors :setting the framework. Signalling pathways operated by receptor protein tyrosine kinases. Signalling pathways operated by non-receptor protein tyrosine kinases. Phosphoinositide 3-kinases. Signal transduction to and from adhesion molecules. Adhesion molecules and trafficking of leukocytes. Signalling through receptor bound protein serine-threonine kinases. Protein dephosphorylation and protein phosphorylation. Protein domains and signal transduction.
About Bastien D. Gomperts
IJsbrand Kramer is a professor at the University of Bordeaux, working in the European Institute of Chemistry and Biology (IECB). He holds a Bachelors and Masters degree in BioMedicine from the University of Utrecht, The Netherlands, with a one year research-excursion in the Department of Cell Biology at the University of Liverpool, UK. He did his Ph.D. at the University of Amsterdam, in the Central Laboratory of Blood transfusion services (Stichting Sanquin) and worked as a post-doctoral fellow at the Hubrecht Laboratory in Utrecht and at the University of Washington in Seattle. He then took a lecturer position at the Department of Pharmacology at University College London, where he taught Signal Transduction (with Bastien Gomperts and Pether Tatham) and Pharmacology. Both teaching activities have been documented in textbooks: Signal Transduction (3 editions) and Receptor Pharmacology (CRC Press/Taylor Francis Group, 3 editions). Most of his research centers on the theme of inflammation, starting with neutrophils and the NADPH oxidase, synovial fibroblasts and destruction of the joint and more recently podosomes formation and extracellular matrix destruction in vascular endothelium. He moved to the University of Bordeaux for family reasons and switched from Pharmacology to Cell Biology, with a strong contribution to an introductory course for 1st year university students. Given the important teaching load and the general low level of student engagement in higher education he started to investigate the reasons for student failure (finding out about their expectations and attitudes) and the role of images and animations in comprehension. Scientific publications, web-based multimedia resources and dramatically enhanced retention rates (from 33 to 85%) are the fruits of these activities. At the same time he organized with University College London and Universitat Pompeu Fabra, Barcelona, summer schools on Receptor and Signalling Mechanism. He has been co-director of two European Programmes (Interbio and Transbio) that aimed at enhancing industrial innovation in the biomedical sector in the South West European Region (SUDOE). For book/publicity purposes, image of the author by (c) Maarten Kramer
"Signal Transduction is indispensable for modern life sciences." -BIOELECTROCHEMISTRY (April 2003) "...useful to senior undergrad and grad students entering the field, but will also provide a valuable reference for established researchers." -CELL