Serotonin : From Cell Biology to Pharmacology and Therapeutics

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This volume represents the proceedings ofthe invited lectures ofthe first International Symposium on "Serotonin from Cell Biology to Pharmacology and Therapeutics" which was held in Florence on March 29 -Aprill, 1989. This meeting, held under the co-sponsorship of the Serotonin Club and the Fondazione Giovanni Lorenzini, represents the first attempt to bring together scientists fascinated by the complexity of the action of 5-hydroxytryptamine throughout the body and in various species. Hence this volume provides the reader with the unique overview of the sources, effects, receptors, physiological actions and pathological role of Serotonin. As such it will be of interest not only to the person devoting herorhis research efforts to the study of 5-hydroxytryptamine but also to all scholars and even clinicians wanting to know how the powerful monoamine can modulate cellular functions. To accelerate the publication of these proceedings the Editors and the publishers have selected the camera ready format and have avoided a lengthy refereeing process. Hence the scientific content of, and the opinions expressed in the chapters are the sole responsibility of the authors. The Editors Milan and Houston The Editors want to thank Mrs. H. Liepman and her staff at Kluwer for the prompt and efficient handling of the manuscripts.
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Product details

  • Hardback | 668 pages
  • 156 x 234 x 42.16mm | 2,520g
  • Dordrecht, Netherlands
  • English
  • 1990 ed.
  • XVIII, 668 p.
  • 0792305310
  • 9780792305316

Table of contents

Serotonin research: historical overview.- Molecular Mechanisms in Serotonin Mediated Response.- Molecular biology of the serotonin receptor family.- Molecular structure of the central 5-HT1A receptor.- Biochemical characterization of the cloned human 5-HT1A receptor expressed in mammalian cells.- Amplifying effects of 5-hydroxytryptamine on human platelets and signal transduction.- Role of phosphoinositide hydrolysis and protein kinase C activation in 5HT2 receptor function in smooth muscle.- Adenylate cyclase-linked 5-hydroxytryptamine receptors in the brain.- Characterization and purification of the neuronal 5-HT transporter.- Structure and functional expression of cloned human liver MAO A and B.- Physiology of Serotonergic System: - Vascular System.- Amplifying effect of serotonin in the control of vascular tone.- Amplification mechanisms in platelet activation.- The role of the endothelium in the cardiovascular response to serotonin.- Endothelium-dependent relaxations to serotonin: signal transduction and effects of diets.- 5-Hydroxytryptamine in cerebrovascular sympathetic nerves and its effect on brain vessels.- The 5-HT system of blood platelets: physiological variations and pathophysiology in essential hypertension.- Serotonergic regulation of renin and vasopressin secretion.- 5HT, platelets and experimental atherosclerosis.- Responses to serotonin in atherosclerotic and hypertensive blood vessels.- Does the serotonin antagonist ketanserin have vascular protective effects?.- Central Nervous System.- Serotonin and coexisting peptides in cat and lamprey spinal cord.- Is there an endogenous modulation of serotonin uptake?.- Serotonin receptors regulating transmitter release.- Galanin/5-HT receptor interactions. A new integrative mechanism in the control of 5-HT neurotransmission in the central nervous system.- Changing views on the role of serotonergic mechanisms in the control of the sleep-wakefulness cycle.- Serotonin transmission and food intake.- Serotonin in medial hypotholamic nuclei controls circadian patterns of macronutrient intake.- Serotonin receptor sub-types and the organisation of feeding behaviour: experimental models.- Tryptophan availability and serotonin synthesis.- Gastrointestinal System.- Effects of serotonin on gastric secretion in vivo.- Serotonin in intestinal function.- Messenger function of Serotonin in the enteric nervous system.- 5-Hydroxytryptamine and cholinergic function in the gastrointestinal tract.- Serotonergic Receptors: Biochemistry, Physiology and Pharmacology.- Functional/clinical significance of 5-hydroxytryptamine binding sites.- Selective agonists and antagonists at 5-hydroxytryptamine receptor subtypes.- Electrophysiology of brain serotonin receptors: subtype specificity for effector mechanisms.- 5-Hydroxytryptamine (5-HT) receptor subtypes in invertebrates.- 5-Hydroxytryptamine1A receptors: pharmacological and functional characterization.- Modulation of serotonin release in the central nervous system via presynaptic 5-HT autoreceptors.- Receptor binding correlates of functional terminal 5-HT autoreceptors.- Pharmacology, function and adaptive regulation of 5HT-1c receptors.- Classification of serotonergic receptors: an example of a novel 5-HT11 like binding site in the rabbit caudate nucleus.- Central and peripheral 5-HT2 receptors: role in physiological versus pathological conditions.- 5-HT3 receptors.- Brain 5-HT3 receptors.- Heart 5-HT receptors. A novel 5-HT receptor in human atrium.- Characterization of the contractile 5HT receptor in the rat stomach fundus.- Peripheral neural 5-HT receptors: subtypes in the enteric nervous system.- Antagonistic modulation of A K+ channel activity by serotonin and the peptide FMRFamide in aplysia sensory neurons: molecular aspects and functional implications.- Visualization of serotonin receptor binding and their messenger RNA's in the mammalian brain: an update.- Pharmacology of Serotonergic System.- Upregulation of pain transmission from deficient serotonergic analgesia in migraine.- Selective 5-hydroxytryptaminel-like receptor agonists and migraine.- Recent insights into the antihypertensive mechanism of action of ketanserin.- Ketanserin interactions with nifedipine and captopril: two italian cross over trials.- International study of ketanserin in Raynaud's phenomenon.- Serotonin and portal hypertension.- Effects of serotonin and ketanserin on the functional morphology of skin: organotypical cultures of adult human skin and embryonic chick skin as experimental models.- Use of antagonists to 5-HT2 receptors of serotonin by topical application in healing skin ulcers.- Ketanserin in wound healing and fibrosis: investigations into its mechanism of action.- Central Nervous System.- Serotonin uptake inhibitors.- Serotonergic re-uptake inhibition and depression: the effects of fluvoxamine on sleep in depressed patients.- Chronobiological studies of serotonin uptake complex: relevance to antidepressant action.- Lack of serotonergic influence on desipramine induced ss-adrenergic receptor down-regulation.- Serotonin in depression and anxiety.- Investigations of 5-HT neuroendocrine function in depression.- Electrophysiological investigation of the effects of antidepressant treatments on serotonin receptors.- Role of 5HT2 receptors in anxiety and depression.- Effectiveness of ritanserin on pain and depression in chronic headache disorders.- 5-HT1A receptor partial agonists as anxiolytics.- 5HT2 receptor antagonism and slow wave sleep in man.- Serotonin involvement in the action of antipsychotic drugs.- Serotonin control of anxiety.- Neuroendocrine System.- Endocrine changes and 5-hydroxytryptamine receptor subtypes.- Neuroendocrine effects of serotonin agonists in rhesus monkeys, healthy humans and patients with depression or anxiety disorders: effects of antidepressant treatment.- Hormonal responses to serotonergic drugs as a means to evaluate brain serotonergic function in humans.- Role of serotonin in the control of prolactin secretion: effect of antiserotoninergic drugs in normal subjects and in hyperprolactinaemic states.- Serotonin agonist induced corticosterone and prolactin secretion: role of 5-HT2 and 5-HT1A receptors.- Role of serotonin in regulation of the pituitary- adrenocortical axis in rats.- Short and Long Term Effects of Substituted Amphetamines.- Toxicity of amphetamine-related drugs and resulting behavioral changes.- Effect of chronic D-fenfluramine administration on rat brain serotonin levels and release.- Behavioral effects of 5, 7-DHT and MDMA treatment in rats.- Immunohistochemical and autoradiographic investigations of high-dose fenfluramine treatment on monoamine neurons in rat brain.- Long term actions of dexfenfluramine on food intake, body weight and brain serotonin in rodents.- Significance of fenfluramine neurotoxicity: a kinetic approach.- Effect of D-fenfluramine on appetite in lean and obese human subjects and on changes associated with PMS (pre-menstrual syndrome).- Criteria for assessing drug-induced biochemical alterations and degeneration of serotonergic neurons.
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