Sensory Neurons

Sensory Neurons : Diversity, Development and Plasticity

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Description

Vertebrate sensory neurons occupy a unique place in the nervous system, conveying information from the periphery to the central nervous system. While sensory physiologists have long recognized differences in response properties among cells in dorsal root and cranial ganglia, the full extent of heterogeneity among these neurons has only recently become apparent. Phenotypic diversity is the underlying theme of this unique work, which summarizes our current understanding of the individual characteristics and development of sensory neurons. The chapters are arranged in three cohesive sections. The first describes heterogeneity in the function, biochemical make-up, ion channels, membrane properties, and central projection patterns of dorsal root ganglion neurons. The second section discusses the development of sensory neurons, covering such topics as the origins of dorsal root and cranial ganglia, adhesive interactions involved in axon outgrowth, trophic dependence of sensory neurons, and the development of the physiological properties and central and peripheral connections of dorsal root ganglion neurons. The last section explains regeneration and plasticity of mature neurons, including sprouting of skin sensory axons, plasticity in central terminations, axotomy and regeneration, and the continuing role of neurotrophic factors in adult neurons.show more

Product details

  • Hardback | 452 pages
  • 152.4 x 236.22 x 30.48mm | 1,043.26g
  • Oxford University Press Inc
  • New York, United States
  • English
  • line illustrations, tables
  • 0195066766
  • 9780195066760

Table of contents

E. Perl: Function of dorsal root ganglion neurons: an overview; Section I: Phenotypic diversity among sensory neurons: S.N. Lawson: Morphological and biochemical cell types of sensory neurons; S.P. Hunt, P.W. Mantyh & J.V. Priestley: The organization of biochemically characterized sensory neurons; H.R. Koerber & L.M. Mendell: Functional heterogeneity of dorsal root ganglion cells; M.C. Nowycky: Voltage-gated ion channels in dorsal root ganglion neurons; P.B. Brown & H.R. Koerber: Somatotopic organization of primary afferent projections to the spinal cord; R. Fyffe: Laminar organization of primary afferent termination in the mammalian spinal cord; Section II: Development of sensory neurons: N.N.M. LeDouarin, M.A. Teillet & C. Kalcheim: The cellular and molecular basis of early sensory ganglion development; K.S. Vogel: Origins and early development of vertebrate cranial sensory neurons; A.M. Davies: Cell death and the trophic requirements of developing sensory neurons; L.F. Reichardt: Adhesive interactions that regulate neuronal behavior; S.A. Scott: The development of peripheral sensory innervation patterns; M. O'Donovan & M. Lee: The development of muscle afferent connections in the vertebrate spinal cord; M. Fitzgerald & B. Fulton: The physiological properties of developing sensory neurons; Section III: Regeneration and plasticity in mature sensory neurons: J. Diamond & A. Gloster: Regulation of the sensory innervation of skin: trophic control of collateral sprouting; S.B. McMahon: Plasticity of central terminations of primary sensory neurons in the adult animal; G. Grant, H. Aldskogius & J. Arvidsson: Axotomy-induced changes in primary sensory neurons; R.D. Johnson & J.B. Munson: Specificity of regenerating sensory neurons in adult mammals; R.M. Lindsay; The role of neurotrophic factors in functional maintenance of mature sensory neurons.show more