The Search for an AIDS Vaccine : Ethical Issues in the Development and Testing of a Preventive HIV Vaccine
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Efforts to halt the spread of AIDS have failed so far, and the creation of a vaccine now seems the best hope for controlling the disease. Yet developing and testing an HIV vaccine raises a host of difficult ethical issues. These concerns are the focus of this timely and important book. Christine Grady traces the history of vaccine research and surveys the guidelines, regulations, and attitudes concerning human subjects research. There is current information on the state of HIV research and the challenges facing scientists. Vaccine research differs considerably from drug research, and Grady explores the current wisdom governing research with human subjects. Proposing a model for the ethical conduct of vaccine research in general, this book applies it to the complex case of an HIV vaccine. Clinical trials are already ongoing, and the next step, field trials to determine efficacy, involve another set of issuesNand call for new strategies for ethical conduct. The Search for an AIDS Vaccine is essential reading for everyone interested in ethics and the conduct of HIV vaccine research.
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Product details
- Hardback | 208 pages
- 156 x 235 x 23.62mm | 500g
- 22 May 1995
- Indiana University Press
- Bloomington, IN, United States
- English
- 0253326192
- 9780253326195
Back cover copy
Efforts to halt the spread of AIDS have failed so far, and the creation of a vaccine seems the best hope for controlling the disease. Yet the process of developing and testing an HIV vaccine raises a host of difficult ethical issues. These concerns are the focus of this timely and important book. Describing the role of vaccines in controlling infectious disease, this study surveys the guidelines, regulations, and attitudes concerning human-subjects research. There is current information on the state of HIV research and the challenges facing scientists. Vaccine research differs considerably from drug research, and Grady explores the current wisdom governing research with human subjects. Proposing a model for the ethical conduct of vaccine research in general, this book applies it to the complex case of an HIV vaccine. Clinical trials are already ongoing, and the next step, field trials to determine efficacy, involves another set of issues - and a call for new strategies for ethical conduct. The Search for an AIDS Vaccine is essential reading for everyone interested in ethics and the conduct of HIV vaccine research.
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Table of contents
Dedication and Acknowledgments Introduction ONE Vaccines and Their Development: Historical, Social, and Scientific Perspectives TWO Human-Subjects Research and the Regulation of Drugs and Biologicals THREE Human-Subjects Research and HIV Vaccines FOUR The State of HIV Vaccine Science FIVE Planning Phase III HIV Vaccine Efficacy Trials SIX Summary Glossary Notes References Index
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About Christine C. Grady
CHRISTINE GRADY, R.N., Ph.D., is Acting Clinical Director and Research Associate at the National Institute of Nursing Research, the National Institutes of Health and has served as a member of the staff of the President's Commission on the HIV Epidemic.
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