The SV40 Replicon Model for Analysis of Anticancer Drugs
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The SV40 Replicon Model for Analysis of Anticancer Drugs

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Description

This book provides the most up-to-date review of the simian virus 40 (SV40) minichromosome as a model for the mammalian chromosome in studies of DNA replication. It focuses on disruption of DNA replication by anticancer drugs and DNA-damaging agents. There is a strong emphasis on the unique advantages of SV40 as an experimental system for the analysis of these classes of anticancer drug mechanisms. The new high-resolution gel electrophoresis methods for the analysis of SV40 DNA replication are covered in detail to aid readers in designing and interpreting similar experiments.
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Product details

  • Hardback | 193 pages
  • 185.2 x 260.9 x 18mm | 855.95g
  • Academic Press Inc
  • San Diego, United States
  • English
  • 0126536309
  • 9780126536300

Back cover copy

This volume of the Biotechnology Intelligence Unit series reviews the history of SV40 as a mammalian replicon model and covers the techniques used to analyze viral DNA replication.
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Table of contents

R.M. Snapka, Papovavirus Models for Mammalian Replicons.
R.M. Snapka, Analysis of SV40 DNA Replication Intermediates.
R.M. Snapka, Catastrophic Failure of DNA Replication Forks: Structural and RecombinationalPathways.
R.M. Snapka and E.F. Yamasaki, Topoisomerase II and the Termination of DNA Replication.
R.M. Snapka, DNA Damaging Agents.
R.M. Snapka, C.A. Ferrar, N.-J. Sun, and J.M. Cassady, Drug Discovery and Evaluation with SV40.
L.H. Malkas, Simian Virus 40 (SV40) in Vitro DNA Replication: A Potential Model for Studying Anticancer Drug Action.
R.M. Snapka and P.A. Permana, SV40 Circular Oligomer Series: Normal and Abnormal DNA Replication.
Subject Index.
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About Robert M. Snapka

Dr. Snapka is an associate professor of Radiology at The Ohio State University, teaching courses in Radiation Biology, DNA Tumor Viruses, Drug Resistance, and Genetic Instability. Dr. Snapka earned his B.S. in Biology and M.S. in Chemistry at North Texas State University. He earned his Ph.D. at the University of California, Irvine and worked as a Research Fellow at the University of California, Berkeley and Massachusetts Institute of Technology. He is the author of over 35 article in refereed journals and is currently conducting research in anticancer drug resistance and drug discovery.
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