The Retinal Pigment Epithelium

The Retinal Pigment Epithelium : Function and Disease

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The retinal pigment epithelium is a critical tissue within the eye. It lies directly behind the retina, where it provides metabolic support to the photoreceptors and controls their local environment. As a result, the RPE is vital to retinal function, but also a site of aging and disease that cause dysfunction and visual loss.LThis book brings together comprehensive reviews of basic and clinical science concerning the RPE. It is organized to juxtapose chapters on RPE disease with chapters on the underlying pathophysiology. These include up-to-date accounts of growth factors, laser effects, proliferative vitreoretinopathy, Bruch's membrane pathology, as well as new diagnostic tools such as ocular coherence tomography, in vivo imaging of lipofuscin and non-photic electrical responses. Other chapters cover pharmacology and toxicology, mechanisms of retinal adhesion and detachment, RPE pigments and transport, congenital and dystrophic diseases, animal models of RPE disease, and different aspects of age-related macular degeneration. The history and evolutionary aspects of the RPE are also presented.L The contributing authors are experienced clinicians and eminent basic scientists who work on this critical part of the eye. The book will be a valuable resource for anyone interested i the eye, and a necessity for specialists in the fields of retinal physiology and retinal more

Product details

  • Hardback | 764 pages
  • 226.1 x 287 x 48.3mm | 2,744.27g
  • Oxford University Press Inc
  • New York, United States
  • English
  • 8 pp colour plates and numerous illustrations
  • 0195109562
  • 9780195109566

Table of contents

INTRODUCTION; 1. The Historical Discovery of the RPE; 2. Comparative and Evolutionary Aspects of the RPE; FUNDAMENTAL PROPERTIES; 3. The RPE Cytoskeleton; 4. Melanin and the RPE; 5. Determinants of RPE Phenotype and Polarity; 6. Transport Mechanisms in the RPE; 7. Retinoids and the Pigment Epithelium; 8. Role of Pigment Epithelium in Photoreceptor Membrane Turnover; DIAGNOSTIC EVALUATION; 9. Light-Induced Responses of the RPE; 10. Clinical Electrophysiology of the Retinal Pigment Epithelium; 11. In Vivo Imaging of the RPE - Introduction; AUTOFLOURESCENCE IMAGING OF THE HUMAN FUNDUS; OPTICAL COHERENCE TOMOGRAPHY IMAGING OF THE RPE AND ITS RELATED DISORDERS; INHERITED AND METABOLIC DISODERS OF RPE; INHERITED AND METABOLIC DISORDERS OF RPE; 12. Rodent Models of Pigment Epithelial Disease; 13. Disease of the RPE - Photoreceptor Complex in non-rodent animal models; 14. Congenital Abnormalities of the RPE; 15. The RPE in Dystrophic and Metabolic Disease; 16. Retinal Heredodegenerations of RPE Involvement; DETACHMENT AND ADHESION; 17. Biology of the Interphotoreceptor Matrix-RPE-Retina Interface; 18. Mechanisms of Retinal Adhesivess; 19. Cellular responses of the RPE to Retinal Detachment and Reattachment; 20. Control of Subretinal Fluid and Mechanisms or Serous Detachment; 21. Manifestations and Pathophysiology of Serious Detachment of the Pigment Epithelium and Retina; CELLULAR GROWTH AND TRANSPLANTATION; 22. Growth Factors in the RPE and Retina; 23. The RPE, Epiretinal Membrane Formation and Proliferative Vetroretinopathy; 24. Transplantation of RPE; 25. Regulation of Immune Responses by the RPE; 26. Inflammations of Infections of the RPE; 27. Multifocal Chorioretinopathy Syndromes; 28. Light Damage to Retina and Pigment Epithelium; 29. Laser Interactions with the Retina and RPE; 30. Pharmacology of the RPE; 31. Toxicology of the RPE; AGING AND DEGENERATION; 32. Lipofuscin and Other Lysosomal Storage Deposits in the RPE; 33. Aging and Bruch's Membrane; 34. Bruch's Membrane, Drusen and Age-Related Macular Degeneration; 35. Age-Related RPE Detachments; 36. Epidemiology of Age-Related RPE Diseaseshow more