Renin-Angiotensin System Textbook

Renin-Angiotensin System Textbook

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This is a detailed, state-of-the-art account of the renin-angiotensin system. It covers all aspects of the subject by describing contemporary research whilst also emphasising historical perspectives. Volume One considers scientific aspects such as structure, function, evolution, biochemistry and genetics; Volume two details the pathophysiology of the system and describes how knowledge of the RAS is being applied practically to therapeutic techniques. Each chapter is fully illustrated as appropriate: tables, algorithms, graphs, conceptual artworks and black and white photographs are all used. Where colour photographs are included, they are presented in a plate section at the front of the volume. It features an international team of authors, distrinctive artwork clarifies complex concepts discussed in the comprehensive, authoritative more

Product details

  • Hardback | 1344 pages
  • 234.95 x 298.45 x 101.6mm | 5,193.61g
  • Elsevier Health Sciences
  • Mosby
  • London, United Kingdom
  • English
  • 650 line drawings, 37 b&w photographs, 59 colour photographs
  • 1563755505
  • 9781563755507

Table of contents

Historical introduction; phylogeny and comparative physiology; genetic aspects of the renin system; renin - purification, structure - biochemical aspects; enzymic reactions of the RAS - biochemical aspects; inactive renin - biochemical aspects; a perspective on inactive renin; angiotensinogen - biochemical aspects; angiotensins - biochemical aspects; ACE - biochemical aspects; angiotensinases - biochemical aspects; angiotensin receptors - biochemical aspects; renin - measurement; angiotensinogen - measurement; angiotensins - measurement; ACE - measurement; renin and angiotensin standards; intrarenal and intracellular distribution of renin and angiotensin; the human renin-secreting cell in health and disease; secretory pathways; intrarenal variations in renin; elimination of renin and ang II by the kidney - renin in urine; metabolism of renin angiotensinogen and the angiotensins by tissues; control of renin secretion; intrarenal AII receptors; intrarenal and circulating AII and renal function; renal actions of AII in man - normal and abnormal; fast and slow pressor effects; renin, angiotensin and vascular endothelium; intracellular mechanisms of action of renin; renin and angiotensin - trophic effects on blood vessels and heart; renin and thirst; renin and control of aldosterone; inter-relations between renin and ACTH; inter-relations between renin and ADH; inter-relations between renin and ANP; inter-relations between the RAS and the ANS/catecholamines; renin, the kidney and prostaglandins; renin and erythropoietin; angiotensin - toxic effect on kidneys, heart and brain; brain; heart and vessels; salivary glands; adrenal gland; uterus and amniotic fluid; ovary; testis and epididymis; a perspective on extrarenal renin; the renin system and reproduction in animals; the renin system in fertility and normal human pregnancy; the foetal renin system; the renin system in human pregnancy hypertension; renin system with oral contraception; renin-secreting tumours; renin in reno-vascular hypertension; renin in clinical renal failure - acute and chronic; renin and polycystic kidney disease; renin in nephrotic syndrome; renin in aortic coarction; renin in malignant hypertension; genetics and essential (primary) hypertension - contribution of renin; renin in essential hypertension; renin in mineralocorticoid hypertension; renin in Bartter's syndrome; renin in Gordon's syndrome; renin in Liddle's syndrome; renin in pheochromocytoma; renin in adrenal insufficiency; hyperreninemic selective hypoaldosteronism; hyporeninemic hypoaldosteronism; renin and haemorrhage; renin in anorexia nervosa, purgative abuse, surreptitious vomiting; renin in diabetes insipidus; renin as a regulator of blood-pressure, sodium, water and potassium balance. (Part contents)show more