Regenerative Medicine Applications in Organ Transplantation
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Regenerative Medicine Applications in Organ Transplantation

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Description

Regenerative Medicine Applications in Organ Transplantation illustrates exactly how these two fields are coming together and can benefit one another. It discusses technologies being developed, methods being implemented, and which of these are the most promising. The text encompasses tissue engineering, biomaterial sciences, stem cell biology, and developmental biology, all from a transplant perspective. Organ systems considered include liver, renal, intestinal, pancreatic, and more. Leaders from both fields have contributed chapters, clearly illustrating that regenerative medicine and solid organ transplantation speak the same language and that both aim for similar medical outcomes. The overall theme of the book is to provide insight into the synergy between organ transplantation and regenerative medicine.

Recent groundbreaking achievements in regenerative medicine have received unprecedented coverage by the media, fueling interest and enthusiasm in transplant clinicians and researchers. Regenerative medicine is changing the premise of solid organ transplantation, requiring transplantation investigators to become familiar with regenerative medicine investigations that can be extremely relevant to their work. Similarly, regenerative medicine investigators need to be aware of the needs of the transplant field to bring these two fields together for greater results.
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Product details

  • Hardback | 1050 pages
  • 218.44 x 284.48 x 53.34mm | 3,129.77g
  • Academic Press Inc
  • San Diego, United States
  • English
  • 0123985234
  • 9780123985231

Table of contents

Meet the Editors Preface 1. Introduction: Regenerative medicine and solid organ transplantation from a historical perspective 2. Solid organ transplantation: has the promise been kept and the needs met?

Principles of Regenerative Medicine and Cell, Tissue, and Organ Bioengineering 3. Strategies for the specification of tissue engineering biomaterials 4. Principles of Stem Cell Biology 5. Principles of cell sheet technology 6. Principles of bioprinting technology 7. Synthetic biomaterial for regenerative medicine applications 8. Natural biomaterials for regenerative medicine applications 9. Bioartificial biomaterials for regenerative medicine applications 10. Bioactivated materials for cell and tissue guidance 11. Biocompatibility and immune response to biomaterials 12. Harnessing regenerative and immunomodulatory properties of stem cells 13. Bioreactors for tissue engineering purposes

Kidney 14. Current status of renal transplantation 15. Living related renal transplantation: progress, pitfalls and promise 16. Machine perfusion of kidneys donated after cardiac death: the Carrel and Lindbergh legacy 17. Renal regeneration: the bioengineering approach 18. Renal regeneration: the stem cell biology approach 19. Renal regeneration: the developmental approach

Liver 20. Current status of liver transplantation 21. Living related liver transplantation: progress, pitfalls and promise 22. Donation after cardiac death liver transplantation 23. Artificial liver support 24. Liver regeneration: the bioengineering approach 25. Liver regeneration: the developmental biology approach 26. Liver regeneration: the stem cell approach 27. Liver bioengineering using human cells

Heart 28. Current status of heart transplantation 29. Artificial heart support 30. Heart regeneration: the bioengineering approach 31. Heart regeneration: the developmental and stem cell biology approach

Small Bowel 32. Current status of intestinal transplantation 33. Living related small bowel transplantation: progress, pitfalls and promise 34. Intestinal regeneration: the bioengineering approach 35. Intestinal regeneration: the developmental biology approach 36. Intestinal regeneration: stem cell approach 37. Building blocks for engineering the small intestine

Endocrine pancreas and islets of Langerhans 38. Current status of pancreas transplantation 39. Living related pancreas transplantation: progress, pitfalls and promise 40. Current status of islet transplantation 41. Pancreatic islets regeneration: the bioengineering approach 42. Pancreatic islet regeneration: the developmental and stem cell biology approach 43. Microencapsulation technology 44. Autologous islets transplantation

Lung 45. Current status of lung transplantation 46. Living related lung transplantation: progress, pitfalls and promise 47. Artificial Lung Support 48. Lung regeneration: the bioengineering approach 49. Lung regeneration: the developmental biology approach 50. Lung regeneration: stem cell approach

Composite tissues allotransplantation Immunosuppression-free transplantation in the regenerative medicine era Epilogue: Organ Bioengineering and Regeneration as the new Holy Grail of Organ Transplantation
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Review Text

"It is without doubt a very valuable book that captures well the current status of the many areas it addresses...It is a superb summary of the current status of RM and organ transplantation." -- Expert Review of Clinical Immunology, Regenerative Medicine Applications in Organ Transplantation

".represents an invaluable reference for students, physicians, and researchers who are interested in getting a comprehensive, up-to-date snapshot on how regenerative medicine and organ transplantation are reshaping the medical profession."-- Transplantation, November 27,2014

".an invaluable reference for students, physicians, and researchers who are interested in getting a comprehensive up-to-date snapshot on how regenerative medicine and organ transplantation are reshaping the medical profession."-- Transplantation , Nov 27 2014

"Given the implications that a chronic shortage of organs has on public health and society, this book is a valuable resource for students and professionals seeking to do something about this problem by taking advantage of cutting-edge developments in one of those most dynamic scientific disciplines existing today, namely regenerative medicine."-- Regenerative Medicine 2014 9(3) "The text is well organized.Chapters on tracheal reconstruction and bladder reconstruction are impressive in demonstrating proximity to clinical utility and indicate that simple structural elements can be manufactured and implanted in humans to bridge a limited defect.if you want to spark your enthusiasm for what is to come, then this textbook is a fine first step into the future."-- American Journal of Transplantation, June 2014 "With beautiful illustrations throughout that greatly enhance the overall reading experience of this book, this book is a must-have for anyone interested in tissue engineering and organ transplantation. This is one of the best textbooks I have come across that combines surgery with science, and it is a must for all surgeon-scientists involved in tissue engineering and organ transplantation."-- BCS Online, April 3, 2014 "This book succeeds in providing a detailed and comprehensible description of current and future therapies for solid organ replacement. It is unique in that it encompasses all solid organs and compiles a great deal of research. It will serve as a valuable reference for all those involved in the evolution of transplantation." Rating: 4 Stars-- Organ Transplantation review on Doody.com, January 24, 2014
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Review quote

"It is without doubt a very valuable book that captures well the current status of the many areas it addresses...It is a superb summary of the current status of RM and organ transplantation."--Expert Review of Clinical Immunology, Regenerative Medicine Applications in Organ Transplantation

"...represents an invaluable reference for students, physicians, and researchers who are interested in getting a comprehensive, up-to-date snapshot on how regenerative medicine and organ transplantation are reshaping the medical profession."--Transplantation,November 27,2014

"...an invaluable reference for students, physicians, and researchers who are interested in getting a comprehensive up-to-date snapshot on how regenerative medicine and organ transplantation are reshaping the medical profession."--Transplantation, Nov 27 2014

"Given the implications that a chronic shortage of organs has on public health and society, this book is a valuable resource for students and professionals seeking to do something about this problem by taking advantage of cutting-edge developments in one of those most dynamic scientific disciplines existing today, namely regenerative medicine."--Regenerative Medicine 2014 9(3) "The text is well organized...Chapters on tracheal reconstruction and bladder reconstruction are impressive in demonstrating proximity to clinical utility and indicate that simple structural elements can be manufactured and implanted in humans to bridge a limited defect...if you want to spark your enthusiasm for what is to come, then this textbook is a fine first step into the future."--American Journal of Transplantation, June 2014 "With beautiful illustrations throughout that greatly enhance the overall reading experience of this book, this book is a must-have for anyone interested in tissue engineering and organ transplantation. This is one of the best textbooks I have come across that combines surgery with science, and it is a must for all surgeon-scientists involved in tissue engineering and organ transplantation."--BCS Online, April 3, 2014 "This book succeeds in providing a detailed and comprehensible description of current and future therapies for solid organ replacement. It is unique in that it encompasses all solid organs and compiles a great deal of research. It will serve as a valuable reference for all those involved in the evolution of transplantation." Rating: 4 Stars--Organ Transplantation review on Doody.com, January 24, 2014
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About Giuseppe Orlando

Transplant surgeon scientist, specializing in kidney and pancreas transplantation, as well as in abdominal organ bioengineering and regeneration. My main achievements have been in the field of steroid-free immunosuppression (IS), IS minimization and clinical tolerance after liver transplantation, as well as in the development of platforms for renal, small bowel and endocrine pancreas bioengineering and regeneration research. The main goal of my investigations is to bio-engineer and implant in humans renal organoids, insulin-producing cells and segments of small bowel. The ability to produce kidneys, insulin-producing cells and small bowel from patient's own cells will revolutionize transplant medicine. The main goal of my scientific production is to orchestrate the transition of organ transplantation towards a regenerative medicine-focused type of research. I originally hail from Rome, Italy, where I grew up, matriculated, attended medical school, and received training in general and transplant surgery. I also participated in fellowships in Paris (Liver Unit, Paul Brousse Hospital, Dir: Henri Bismuth, 6 months) and Brussels (General and Transplant Surgery, Catholic University of Leuven, Dir: Jan Lerut, Jean Bernard Otte, Jean De Ville De Goyet, 31 months). 2006-2008, I was a practicing transplant surgeon at the University of L'Aquila, Italy. 2008-2011, I received and implemented the distinguished Marie Curie International Outgoing Fellowship, for which I spent 2 years at the Wake Forest Institute of Regenerative Medicine (Winston Salem, USA) and 1 year at the Transplant Research Immunology Group (Oxford, UK), specializing in organ bioengineering and regeneration and transplant immunology. I have authored more than 135 research papers, review articles, and book chapters. I have just published - as editor in chief - a book on organ transplantation and regenerative medicine which is destined to set a new standard in transplant and regenerative medicine literature and to become a referral work for the future generations of specialists of both fields. I am a member of numerous transplant societies and am on the board and act as a regular reviewer for a number of relevant journals.
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