Recent Advances in Electron Cryomicroscopy, Part A: Volume 81

Recent Advances in Electron Cryomicroscopy, Part A: Volume 81

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Structural genomics is the systematic determination of 3-D structures of proteins representative of the range of protein structure and function found in nature. The goal is to build a body of structural information that will predict the structure and potential function for almost any protein from knowledge of its coding sequence. This is essential information for understanding the functioning of the human proteome, the ensemble of tens of thousands of proteins specified by the human genome.

While most structural biologists pursue structures of individual proteins or protein groups, specialists in structural genomics pursue structures of proteins on a genome wide scale. This implies large-scale cloning, expression and purification. One main advantage of this approach is economy of scale.
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Product details

  • Hardback | 144 pages
  • 154 x 230 x 14mm | 381.02g
  • Academic Press Inc
  • San Diego, United States
  • English
  • New
  • 0123813573
  • 9780123813572

Table of contents

From envelopes to atoms: the remarkable progress of biological electron microscopy
R. Anthony Crowther

Single-particle applications at intermediate resolution
Bettina Boettcher and Katharina Hipp

Visualizing molecular machines in action: single particle analysis with structural variability
Sjors H.W. Scheres

Cellular Tomography

Andreas Hoenger and Cedric Bouchet-Marquis
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