Pyridines: From Lab to Production

Pyridines: From Lab to Production

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Pyridines: From Lab to Production provides a synthetic armory of tools to aid the practicing chemist by reviewing the most reliable historical methods alongside new methods/ Written by scientists who have actually used these in synthesis. By emphasizing tricks and tips to optimize reactions for the best yields and purity, which are often missing from the primary literature, this book provides another dimension for the synthetic chemist. A combined academic and industrial approach evaluates the best methods for different scales of reaction and discusses practical tips (e.g. when to stop a reaction early to maximize purity or when to re-use side products). Chapters also assess whether to make or source starting materials, how to connect them and what are the best synthetic routes. The book is designed to be a stand-alone reference, but also provides cross references to leading reviews and the Comprehensive Heterocyclic Chemistry reference works for those who want to learn more.
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Product details

  • Hardback | 582 pages
  • 192 x 236 x 28mm | 1,338.09g
  • Academic Press Inc
  • San Diego, United States
  • English
  • Approx. 600 illustrations; Illustrations, unspecified
  • 0123852358
  • 9780123852359
  • 2,131,977

Table of contents

1. Introduction 2. Ring synthesis 3. Attachment at ring positions 4. Substituent modifications and cyclizations 5. Formation of completely or partially reduced pyridines and quinolines 6. Applications to alkaloid synthesis 7. Fluoropyridines 8. Pyridine reagents 9. Application of Flow Reactors in Pyridine Synthesis
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Review quote

"Editor Scriven...presents this comprehensive reference for academics and industrialists working in the synthesis of pyridine derivatives. Strategic considerations for economizing reagents are discussed in the introduction; in particular, the question of whether to install substituents before or after cyclization is highlighted." --Reference and Research Book News, October 2013
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About Eric F. V. Scriven

Eric Scriven was educated in the UK and appointed lecturer in organic chemistry at the University of Salford in 1971. He joined Reilly Industries in 1979, and was Head of Research & Development 1991-2003. He is now Publishing Editor of Arkivoc and is based at the Department of Chemistry, University of Florida in Gainesville. His research interests are in heterocyclic chemistry, especially pyridines. He has over 100 publications and patents in heterocyclic chemistry. He has also published and consulted in the field of technology management. He was a founding editor (with Hans Suschitzky) of Progress in Heterocyclic Chemistry now in its 25th year. He has collaborated with Alan Katritzky and others as an Editor-in-Chief of Comprehensive Heterocyclic Chemistry 2nd and 3rd editions. He has edited two other works, Azides and Nitrenes (1984), and Pyridines (2013).
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