Proteins and Peptides

Proteins and Peptides : Pharmacokinetic, Pharmacodynamic, and Metabolic Outcomes

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Addressing the increased use of protein and peptide candidates as treatments for previously untreatable diseases, this comprehensive and progressive source provides the reader with a roadmap to an increased understanding of issues critical for successfully developing a protein or peptide therapeutic candidate. Proteins and Peptides is an invaluable source for drug discovery and development scientists in the biopharmaceutical industry who frequently navigate the maze of protein and peptide pharmacokinetics, pharmacodynamics, and metabolism.
Key features include:

issues related to delivery of protein and peptide therapeutics in elderly populations and pharmacogenomics

lessons learned on the major marketed areas of proteins and peptides, including interleukins, interferons, growth factors, and peptide hormones

innovations for protein and peptide delivery such as needle-less delivery

strategies for delivery of these molecules to locations such as the eye and brain

generic issues of proteins and peptides
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Product details

  • Hardback | 288 pages
  • 152 x 229 x 17.53mm | 612g
  • CRC Press Inc
  • Bosa Roca, United States
  • English
  • New
  • 70 Illustrations, black and white
  • 1420078062
  • 9781420078060

Table of contents

In Vitro/In Vivo Correlations of Pharmacokinetics, Pharmacodynamics, and Metabolism for Hematologic Growth Factors and Cytokines
Graham Molineux and Stephen J. Szilvassy
In Vitro-In Vivo Correlations of Pharmacokinetics, Pharmacodynamics, and Metabolism for Antibody Therapeutics
C. Andrew Boswell, Rong Deng, Kedan Lin, Wendy S. Putnam, Cherry Lei, Frank-Peter Theil, Amita Joshi, Paul J. Fielder, and Leslie A. Khawli
In Vitro/In Vivo Correlations of Pharmacokinetics, Pharmacodynamics, and Metabolism for Extracellular Matrix-Binding Growth Factors
Matthew A. Nugent, Maria Mitsi, and Jean L. Spencer
Metabolic Processes at Injection Sites Affecting Pharmacokinetics, Pharmacodynamics, and Metabolism of Protein and Peptide Therapeutics
Randall J. Mrsny
Local Tissue Responses to Polymer Implants Affecting Pharmacokinetics, Pharmacodynamics, and Metabolism of Proteins and Peptides
James M. Anderson and William G. Brodbeck
Engineering as a Means to Improve the Pharmacokinetics of Injected Therapeutic Proteins
Mark S. Dennis, Yik A. Yeung, Henry B. Lowman, and Robert F. Kelley
Ophthalmic Delivery of Protein and Peptide Therapeutics; Pharmacokinetics, Pharmacodynamics, and Metabolism Considerations
Arto Urtti
Pharmacokinetic and Pharmacodynamic Aspects of Intranasal Delivery
Henry R. Costantino, Anthony P. Sileno, Mike Templin, Chingyuan Li, Diane Frank, Gordon C. Brandt, and Steven C. Quay
Oral Delivery of Protein and Peptide Therapeutics: PK/PD and Metabolism Considerations
Puchun Liu and Steven Dinh
Drug Interaction Studies of Therapeutic Biologics: Protein and Peptide Actions and Interactions That Alter Their Pharmacokinetics, Pharmacodynamics, and Metabolism
Iftekhar Mahmood
Intersection of Pharmacogenomics with Pharmacokinetics and Pharmacodynamics
Cecile M. Krejsa, Emmanuel Monnet, and David Cregut
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