Protein Kinase Inhibitors in Research and Medicine, Part B: Volume 548

Protein Kinase Inhibitors in Research and Medicine, Part B: Volume 548

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Description

This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This is the second of two volumes covering protein kinase inhibitors in research and medicine, and includes chapters on such topics as fragment-based screening, broad kinome profiling of kinase inhibitors, and designing drug-resistant kinase alleles.
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Product details

  • Hardback | 496 pages
  • 229 x 242.9 x 152mm | 788g
  • Academic Press Inc
  • San Diego, United States
  • English
  • 0123979439
  • 9780123979438

Table of contents

1. Catalytic Mechanisms and Regulation of Protein Kinases
2. The resistance tetrad: amino acid hotspots for kinome-wide design and exploitation of drug-resistant protein kinase alleles
3. Fragment-based approaches to the discovery of kinase inhibitors
4. FLiK: A Direct Binding Assay for the Identification and Kinetic Characterization of Stabilizers of Inactive Kinase ConformationsFLiK: A Direct Binding Assay for the Identification and Kinetic Characterization of Stabilizers of Inactive Kinase Conformations
5. The Logic and Design of Analog-sensitive (AS) Kinases and their Small Molecule Inhibitors
6. A Structural Atlas of Kinases Inhibited by Clinically Approved Drugs
7. Targeting Protein Kinases with Selective and Semi-Promiscuous Covalent Inhibitors
8. Discovery of Allosteric Bcr-Abl inhibitors from Phenotypic Screen to Clinical Candidate
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