Protein Design
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Protein Design

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Description

Protein Design: Methods and Applications presents the most up-to-date protein design and engineering strategies so that readers can undertake their own projects with a maximum chance of success. The authors present integrated computational approaches that require various degrees of computational complexity, and the major accomplishments that have been achieved in the design and structural characterization of helical peptides and proteins.show more

Product details

  • Hardback | 300 pages
  • 160 x 236 x 28mm | 698.54g
  • Humana Press Inc.
  • Totowa, NJ, United States
  • English
  • 2006 ed.
  • 65 Illustrations, black and white; XIV, 300 p. 65 illus.
  • 1588295850
  • 9781588295859

Review quote

"...provides a comprehensive guide to the methods used at every stage of the protein-design process..." - ChemBioChem "...combines a thorough theoretical foundation with detailed protocols and will be invaluable to all researchers in the area, from graduate students to senior investigators." -ChemBioChemshow more

Back cover copy

Recent major advances in our understanding of modulating protein functions has led to the development of new methods and algorithms to predict and decipher how amino acid sequences shape three-dimensional structures. Protein Design: Methods and Applications presents the most up-to-date protein design and engineering strategies so that readers can undertake their own projects with a maximum chance of success. The authors present integrated computational approaches that require various degrees of computational complexity, and the major accomplishments that have been achieved in the design and structural characterization of helical peptides and proteins. Other topics of discussion include: design of structural elementary motifs, entire proteins, and interfaces of protein complexes, and of amyloidogenic polypeptides and amyloid inhibitors. Authoritative and cutting-edge, Protein Design: Methods and Applications will be of major interest to protein scientists, biochemists, and all experimentalists selecting the strategy most adaptable for their design problem.show more

Table of contents

I. Design of Structural Elementary Motifs Structure and Stability of the a-Helix: Lessons for Design Neil Errington, Teuku Iqbalsyah, and Andrew J. Doig De novo Design of Monomeric b-Hairpin and b-Sheet Peptides David Pantoja-Uceda, Clara M. Santiveri, and M. Angeles Jimenez De novo Proteins From Binary-Patterned Combinatorial Libraries Luke H. Bradley, Peter P. Thumfort, and Michael H. Hecht Non-Protein Amino Acids in the Design of Secondary Structure Scaffolds Radhakrishnan Mahalakshmi and Padmanabhan Balaram Design and Synthesis of b-Peptides With Biological Activity Marc J. Koyack and Richard P. Cheng II. Design of Entire Proteins and Protein Complexes Design of Miniproteins by the Transfer of Active Sites Onto Small-Size Scaffolds Francois Stricher, Loic Martin, and Claudio Vita Consensus Design as a Tool for Engineering Repeat Proteins Tommi Kajander, Aitziber L. Cortajarena, and Lynne Regan Multiple Sequence Alignment as a Guideline for Protein Engineering Strategies Alan R. Davidson Sequence Search Methods and Scoring Functions, for the Design of Protein Structures Hocine Madaoui, Emmanuelle Becker, and Raphael Guerois Prediction of Protein-Protein Interaction Based on Structure Gregorio Fernandez-Ballester and Luis Serrano Electrostatic Design of Protein-Protein Association Rates Gideon Schreiber, Yossi Shaul, and Kay E. Gottschalk III. Design of Amyloidogenic Polypeptides and Amyloid Inhibitors Peptide Model Systems for Amyloid Fiber Formation: Design Strategies and Validation Methods Alexandra Esteras-Chopo, Maria Teresa Pastor, and Manuela Lopez de la Paz Protein Misfolding Disorders and Rational Design of Antimisfolding Agents Lisbell D. Estrada, June Yowtak, and Claudio Soto Indexshow more