Proceedings of the Society for Experimental Biology and Medicine Volume 17-18

Proceedings of the Society for Experimental Biology and Medicine Volume 17-18

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This historic book may have numerous typos and missing text. Purchasers can usually download a free scanned copy of the original book (without typos) from the publisher. Not indexed. Not illustrated. 1920 edition. Excerpt: ...and relative toxicity for various animals, are difficult to determine with absolute certainty because of the great fluctuation in potency of the substances obtained and the probable differences in susceptibility of individual rabbits. In spite of fluctuations of potency, however, some degree of toxic action was never absent and its importance in connection with animal immunization necessitated further study. As to the formation of these substances in the body of the animal, we can say, at the present time, only that the symptoms produced after an incubation of from I to 1% hours in a rabbit are similar in general to those which appear in a rabbit at the time when the streptococci begin to appear in the blood stream in considerable numbers. SUBSTANCES Pnooucao IN BACTERIAL CULTURES. 51 II. A very important consideration is whether these substances represent toxic split products of the culture fluids produced by the bacterial growth, rather than toxic products secreted by the bacteria. In favor of regarding them as split products of the medium is the fact that they were more potent when the media was rich in proteins. Also suggesting this is their apparent non-specificity, in that, as will be shown directly, we obtained similar substances from many other organisms including non-pathogens. Again, in our experiments up to date, as will be seen, we have no reason to believe that they are in any sense antigenic. Against the conception that they are split products of the constituents of the media are the following facts: The substances were often high in potency from simple hormone media, as well as from media containing rabbit's blood and other proteins. It seems that they are more potent in young cultures at the height of their growth energy....
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Product details

  • Paperback | 210 pages
  • 189 x 246 x 11mm | 386g
  • United States
  • English
  • black & white illustrations
  • 1236748603
  • 9781236748607