Principles of Molecular Medicine

Principles of Molecular Medicine

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The concept of molecular medicine dates back to Linus means that there are many new opportunities and challenges Pauling, who in the late 1940s and early 1950s generalized for clinical medicine. One of the effects of the completion of from the ideas that came from the study of the sickle cell the Human Genome Project is the increasing application of hemoglobin molecule. With the first cloning of human genes the fields of molecular biology and genetics to the und- about 1976, molecular genetics took the molecular perspec- standing and management of common diseases. Assimi- tive on disease to the level of DNA. The term molecular tion of the new developments since the first edition has been medicine achieved wide currency in the 1980s with the ably accomplished by Drs. Runge and Patterson with the assignment of this designation to journals, at least one soci- help of their many knowledgeable authors. ety, institutes, and academic divisions of departments of in- As was evident in the first edition, molecular genetics is ternal medicine. Undoubtedly, molecular medicine has been involved in every specialty of medicine. A recurrent theme abetted by the Human Genome Project, which has aided in that edition, perhaps even more striking in the present one, greatly in the molecular characterization of disease.
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Product details

  • Hardback | 1268 pages
  • 221 x 284.5 x 55.9mm | 3,810.22g
  • Humana Press Inc.
  • Totowa, NJ, United States
  • English
  • Revised
  • 2nd ed. 2006
  • LIV, 1268 p. In 2 volumes, not available separately.
  • 1588292029
  • 9781588292025

Review quote

Winner of the Book of the Year Award from Doody's Health Science Book Review Journal"The selection of topics, the ability of the contributors to present complex topics in a clear, concise manner, and the format should all contribute to making this book the standard text and reference in its field. It should be in the collection of every medical library and on the bookshelf of every physician interested in keeping up with the transformation of medicine by molecular genetics." 5 Stars-Doody's Health Science Book Review Journal. "...bridge[s] the current gap between basic science and the bedside. It will thus be useful to researchers and clinicians alike. With more than 100 chapters covering a wide variety of topics, its distinguished cohort of section editors, and its abundant tables and illustrations, it provides an accessible and much needed manual to the present and the future of molecular genetics." -Francis S. Collins, MD, PhD"...a first-class reference textbook. The format of this book is easy to follow and is relevant to the way in which medicine is currently practiced. Its division into the traditional disciplines of medicine makes it easy to identify how molecular developments have enhanced our medical knowledge, diagnostic potentials and therapeutic options...The editor-in-chief, his section editors and the contributing authors should all be congratulated on a superb job." -Molecular Medicine Today"Because molecular medicine has already started to become an integral part of medical practice, there is a growing need to integrate it into the medical school curriculum and medical education in general. Principles of Molecular Medicine is well suited to serving this purpose. . .closing the gap between basic science and the bedside. The book is organized according to organ systems and comprises more than 120 chapters, each written by outstanding specialists. . .The various facets of human hereditary disorders, including genetic counseling and molecular diagnostic testing, are clearly and comprehensively presented. . .the book is well written and attractive. . .[and] is a valuable resource that will certainly appeal to clinicians, researchers, teachers, and students alike. It will also be of value to those involved in a particular area of molecular medicine who need a reference manual in which to find information on aspects of the field in which they are less familiar. . .a valuable reference for anyone with an interest in the achievements and the potential of molecular medicine." -Michael Gooses, MD review in the May 20, 1999 issue of the New England Journal of Medicine
"...succeeds in giving a remarkable, mostly up-to-date overview of molecular medicine such as has not been available between two covers hitherto." -New England Journal of Medicine
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Back cover copy

Marschall S. Runge, MD, PhD, Cam Patterson, MD, and a panel of 251 authoritative contributors-many of them world-renowned clinicians and researchers-have now updated and expanded the much-acclaimed first edition of Principles of Molecular Medicine to provide an integrated survey of the basic principles of internal medicine in the light of recent dramatic discoveries in molecular medicine and new technologies for the diagnosis and treatment of human disease. This second edition contains new sections on genetics, oncology, metabolic diseases, and infectious diseases, in addition to fully revised sections on neurology, cardiology, hematology, nephrology, endocrinology, dermatology, immunology, gastroenterology, pulmonary disease, musculoskeletal medicine, and psychiatry. Here, the reader will discover the latest findings about direct links between genetic mutations and diseases, genomic approaches to a variety of diseases, and stem cell populations that regenerate muscle, heart, and neural cell populations. Other advances elucidated include the roles of bone morphogenetic proteins in pulmonary hypertension, mutations involved in an array of cardiomyopathies, and new understanding of the biology of previously untreatable neurodegenerative diseases, such as Huntington's disease. For this edition, the authors have also focused on producing a tightly written text with more useful figures and tables and reduced references, so that the text is more immediately useful but not overwhelming as a reference book. A CD-ROM edition of the book (ISBN: 1-58829-929-5) is available separately.
Comprehensive and state-of-the-art, Principles of Molecular Medicine, Second Edition, offers practicing physicians, researchers, and residents an extraordinary summary of the rapidly emerging molecular mechanisms underlying disease and valuable insights into the nature and direction of future developments.
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Table of contents

I. Genetics
Terry Magnuson and James P. Evans

Mendelian Inheritance, Bruce R. Korf. Nontraditional Inheritance
Shawn E. McCandless and Suzanne B. Cassidy

Identifying Causal Genetic Factors
Christopher I. Amos, John S. Witte, and William G. Newman

Cancer Genetics and Molecular Oncology
Sharon E. Plon

Renee E. Edkins and Dennis J. Cheek

Hemophilia as a Model Disease for Gene Therapy of Genetic Disorders
Jay Lozier

Genetic Counseling
Robin L. Bennett

Animal Models in Biomedical Research: Ethics, Challenges, and Opportunities
Robert W. Williams

Ethical, Legal, and Social Implications
Marcia Van Riper

II. Cardiology
Anthony Rosenzweig

Congenital Heart Disease
Lazaros K. Kochilas and Alvin J. Chin

Inherited Cardiomyopathies
Carolyn Y. Ho and Christine E. Seidman

Heart Failure: Emerging Concepts in Excitation-Contraction Coupling and b-Adrenoceptor Coupling
Clive J. Lewis, Federica del Monte, Sian E. Harding, and Roger J. Hajjar

Aortic Diseases
Saumya Das, James L. Januzzi, Jr., and Eric M. Isselbacher

Atherosclerotic Coronary Disease
Robert E. Gerszten and Anthony Rosenzweig

Lipid Metabolism and Coronary Artery Disease
Mason W. Freeman

Khurshed A. Katki and Donald J. DiPette

Cardiac Hypertrophy
Thomas Force and Jeffrey D. Molkentin

Barry London

Calum A. MacRae and Christopher J. O'Donnell

Cardiovascular Gene Therapy
David A. Dichek

III. Pulmonary Diseases
Richard C. Boucher and Peadar G. Noone

Idiopathic Interstitial Pneumonias
Talmadge E. King, Jr.

Stephen T. Holgate, Gordon Dent, and Mark G. Buckley

Pulmonary Emphysema
Steven D. Shapiro

Pulmonary Hypertension
Brian Fouty and David M. Rodman

Acute Lung Injury
David C. Christiani and Michelle Ng Gong

Primary Ciliary Dyskinesia
Peadar G. Noone, Maimoona Zariwala, and Michael R. Knowles

Cystic Fibrosis
Scott H. Donaldson and Richard C. Boucher

Gene Therapy for Lung Diseases
Jane C. Davies, Duncan M. Geddes, and Eric W.F.W. Alton

Kelly D. Chason and Stephen L. Tilley

Disorders of Pulmonary Surfactant Homeostasis
Jeffrey A. Whitsett, Susan E. Wert, and Bruce C. Trapnell

IV. Endocrinology
Michael J. McPhaul

Mechanisms of Hormone Action
Stephen R. Hammes, Carol A. Lange, and Michael J. McPhaul

Diabetes Mellitus
William L. Lowe, Jr.

Pituitary Function and Neoplasia
Shlomo Melmed

Growth Hormone Deficiency Disorders
Amy Potter and John A. Phillips, III.

Thyroid Disorders
Peter Kopp

Disorders of the Parathyroid Gland
Andrew Arnold and Michael A. Levine

Congenital Adrenal Hyperplasia
Robert C. Wilson and Maria I. New

Adrenal Diseases
Richard J. Auchus, William E. Rainey, and Keith L. Parker

Multiple Endocrine Neoplasia Type 1
Rajesh V. Thakker

Multiple Endocrine Neoplasia Type 2
Robert F. Gagel, Sarah Shefelbine, Hironori Hayashi, and Gilbert Cote

Disorders of Sex Determination and Differentiation
Charmian A. Quigley

Sex Chromosome Disorders
Andrew R. Zinn

Disorders of Pubertal Development
Tomonobu Hasegawa

Defects of Androgen Action
Michael J. McPhaul

Molecular Endocrinology of the Testis
Marco Marcelli, Glenn R. Cunningham, Jose M. Garcia, Kirk C. Lo, and Dolores J. Lamb

Ovarian Diseases
Elizabeth A. McGee and Tammy L. Loucks

V. Metabolic
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