Principles of Molecular Medicine

Principles of Molecular Medicine

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Description

The concept of molecular medicine dates back to Linus means that there are many new opportunities and challenges Pauling, who in the late 1940s and early 1950s generalized for clinical medicine. One of the effects of the completion of from the ideas that came from the study of the sickle cell the Human Genome Project is the increasing application of hemoglobin molecule. With the first cloning of human genes the fields of molecular biology and genetics to the und- about 1976, molecular genetics took the molecular perspec- standing and management of common diseases. Assimi- tive on disease to the level of DNA. The term molecular tion of the new developments since the first edition has been medicine achieved wide currency in the 1980s with the ably accomplished by Drs. Runge and Patterson with the assignment of this designation to journals, at least one soci- help of their many knowledgeable authors. ety, institutes, and academic divisions of departments of in- As was evident in the first edition, molecular genetics is ternal medicine. Undoubtedly, molecular medicine has been involved in every specialty of medicine. A recurrent theme abetted by the Human Genome Project, which has aided in that edition, perhaps even more striking in the present one, greatly in the molecular characterization of disease.show more

Product details

  • Hardback | 1268 pages
  • 221 x 284.5 x 55.9mm | 3,810.22g
  • Humana Press Inc.
  • Totowa, NJ, United States
  • English
  • Revised
  • 2nd ed. 2006
  • biography
  • 1588292029
  • 9781588292025

Review quote

Winner of the Book of the Year Award from Doody's Health Science Book Review Journal "The selection of topics, the ability of the contributors to present complex topics in a clear, concise manner, and the format should all contribute to making this book the standard text and reference in its field. It should be in the collection of every medical library and on the bookshelf of every physician interested in keeping up with the transformation of medicine by molecular genetics." 5 Stars-Doody's Health Science Book Review Journal. "...bridge[s] the current gap between basic science and the bedside. It will thus be useful to researchers and clinicians alike. With more than 100 chapters covering a wide variety of topics, its distinguished cohort of section editors, and its abundant tables and illustrations, it provides an accessible and much needed manual to the present and the future of molecular genetics." -Francis S. Collins, MD, PhD "...a first-class reference textbook. The format of this book is easy to follow and is relevant to the way in which medicine is currently practiced. Its division into the traditional disciplines of medicine makes it easy to identify how molecular developments have enhanced our medical knowledge, diagnostic potentials and therapeutic options...The editor-in-chief, his section editors and the contributing authors should all be congratulated on a superb job." -Molecular Medicine Today "Because molecular medicine has already started to become an integral part of medical practice, there is a growing need to integrate it into the medical school curriculum and medical education in general. Principles of Molecular Medicine is well suited to serving this purpose...closing the gap between basic science and the bedside. The book is organized according to organ systems and comprises more than 120 chapters, each written by outstanding specialists...The various facets of human hereditary disorders, including genetic counseling and molecular diagnostic testing, are clearly and comprehensively presented...the book is well written and attractive...[and] is a valuable resource that will certainly appeal to clinicians, researchers, teachers, and students alike. It will also be of value to those involved in a particular area of molecular medicine who need a reference manual in which to find information on aspects of the field in which they are less familiar...a valuable reference for anyone with an interest in the achievements and the potential of molecular medicine." -Michael Gooses, MD review in the May 20, 1999 issue of the New England Journal of Medicine "...succeeds in giving a remarkable, mostly up-to-date overview of molecular medicine such as has not been available between two covers hitherto." -New England Journal of Medicineshow more

Back cover copy

Marschall S. Runge, MD, PhD, Cam Patterson, MD, and a panel of 251 authoritative contributors-many of them world-renowned clinicians and researchers-have now updated and expanded the much-acclaimed first edition of Principles of Molecular Medicine to provide an integrated survey of the basic principles of internal medicine in the light of recent dramatic discoveries in molecular medicine and new technologies for the diagnosis and treatment of human disease. This second edition contains new sections on genetics, oncology, metabolic diseases, and infectious diseases, in addition to fully revised sections on neurology, cardiology, hematology, nephrology, endocrinology, dermatology, immunology, gastroenterology, pulmonary disease, musculoskeletal medicine, and psychiatry. Here, the reader will discover the latest findings about direct links between genetic mutations and diseases, genomic approaches to a variety of diseases, and stem cell populations that regenerate muscle, heart, and neural cell populations. Other advances elucidated include the roles of bone morphogenetic proteins in pulmonary hypertension, mutations involved in an array of cardiomyopathies, and new understanding of the biology of previously untreatable neurodegenerative diseases, such as Huntington's disease. For this edition, the authors have also focused on producing a tightly written text with more useful figures and tables and reduced references, so that the text is more immediately useful but not overwhelming as a reference book. A CD-ROM edition of the book (ISBN: 1-58829-929-5) is available separately. Comprehensive and state-of-the-art, Principles of Molecular Medicine, Second Edition, offers practicing physicians, researchers, and residents an extraordinary summary of the rapidly emerging molecular mechanisms underlying disease and valuable insights into the nature and direction of future developments.show more

Table of contents

I. Genetics Terry Magnuson and James P. Evans Mendelian Inheritance, Bruce R. Korf. Nontraditional Inheritance Shawn E. McCandless and Suzanne B. Cassidy Identifying Causal Genetic Factors Christopher I. Amos, John S. Witte, and William G. Newman Cancer Genetics and Molecular Oncology Sharon E. Plon Pharmacogenetics Renee E. Edkins and Dennis J. Cheek Hemophilia as a Model Disease for Gene Therapy of Genetic Disorders Jay Lozier Genetic Counseling Robin L. Bennett Animal Models in Biomedical Research: Ethics, Challenges, and Opportunities Robert W. Williams Ethical, Legal, and Social Implications Marcia Van Riper II. Cardiology Anthony Rosenzweig Congenital Heart Disease Lazaros K. Kochilas and Alvin J. Chin Inherited Cardiomyopathies Carolyn Y. Ho and Christine E. Seidman Heart Failure: Emerging Concepts in Excitation-Contraction Coupling and b-Adrenoceptor Coupling Clive J. Lewis, Federica del Monte, Sian E. Harding, and Roger J. Hajjar Aortic Diseases Saumya Das, James L. Januzzi, Jr., and Eric M. Isselbacher Atherosclerotic Coronary Disease Robert E. Gerszten and Anthony Rosenzweig Lipid Metabolism and Coronary Artery Disease Mason W. Freeman Hypertension Khurshed A. Katki and Donald J. DiPette Cardiac Hypertrophy Thomas Force and Jeffrey D. Molkentin Arrhythmias Barry London Genomics Calum A. MacRae and Christopher J. O'Donnell Cardiovascular Gene Therapy David A. Dichek III. Pulmonary Diseases Richard C. Boucher and Peadar G. Noone Idiopathic Interstitial Pneumonias Talmadge E. King, Jr. Asthma Stephen T. Holgate, Gordon Dent, and Mark G. Buckley Pulmonary Emphysema Steven D. Shapiro Pulmonary Hypertension Brian Fouty and David M. Rodman Acute Lung Injury David C. Christiani and Michelle Ng Gong Primary Ciliary Dyskinesia Peadar G. Noone, Maimoona Zariwala, and Michael R. Knowles Cystic Fibrosis Scott H. Donaldson and Richard C. Boucher Gene Therapy for Lung Diseases Jane C. Davies, Duncan M. Geddes, and Eric W.F.W. Alton Sarcoidosis Kelly D. Chason and Stephen L. Tilley Disorders of Pulmonary Surfactant Homeostasis Jeffrey A. Whitsett, Susan E. Wert, and Bruce C. Trapnell IV. Endocrinology Michael J. McPhaul Mechanisms of Hormone Action Stephen R. Hammes, Carol A. Lange, and Michael J. McPhaul Diabetes Mellitus William L. Lowe, Jr. Pituitary Function and Neoplasia Shlomo Melmed Growth Hormone Deficiency Disorders Amy Potter and John A. Phillips, III. Thyroid Disorders Peter Kopp Disorders of the Parathyroid Gland Andrew Arnold and Michael A. Levine Congenital Adrenal Hyperplasia Robert C. Wilson and Maria I. New Adrenal Diseases Richard J. Auchus, William E. Rainey, and Keith L. Parker Multiple Endocrine Neoplasia Type 1 Rajesh V. Thakker Multiple Endocrine Neoplasia Type 2 Robert F. Gagel, Sarah Shefelbine, Hironori Hayashi, and Gilbert Cote Disorders of Sex Determination and Differentiation Charmian A. Quigley Sex Chromosome Disorders Andrew R. Zinn Disorders of Pubertal Development Tomonobu Hasegawa Defects of Androgen Action Michael J. McPhaul Molecular Endocrinology of the Testis Marco Marcelli, Glenn R. Cunningham, Jose M. Garcia, Kirk C. Lo, and Dolores J. Lamb Ovarian Diseases Elizabeth A. McGee and Tammy L. Loucks V. Metabolicshow more

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