Principles of Medical Pharmacology

Principles of Medical Pharmacology

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Description

This is the Sixth Edition of a teaching text that has undergone continuous evolution and improvement since 1975. It has been extensively revised, enlarged and updated to reflect the latest research. The authors have "pre-tested" it in their own courses to ensure accessibility and clarity of presentation. Though aimed primarily at medical students, the text has also found wide acceptance in pharmacology courses for students in biological sciences, pharmacy and dentistry, and among practicing pharmacists and physicians. The text covers all aspects of medical pharmacology, including a comprehensive discussion of the clinically important features of pharmacokinetics. It also provides a detailed treatment of topics that are often given less attention in similar texts, such as drug abuse and dependence, behavioral pharmacology, drug interactions, neonatal and geriatric pharmacology, and new drug development. This new edition features a number of improvements over its predecessors. Each chapter in the systems pharmacology section now begins with a brief case history that is meant to stimulate the reader's interest by demonstrating the clinical relevance of basic pharmacology.
New overview chapters and sections have been added on second messenger systems, and on the functional organization of the nervous, cardiovascular, gastrointestinal, and immune systems. The chapter on antiparasitic agents has been expanded to include organisms and drugs with relevance to many parts of the world. Extensive sections on current chemotherapy of HIV infection and AIDS along with discussions of new agents for drug-resistant tuberculosis, malaria and cancer; inflammatory bowel disease; and genetics of drug metabolism appear for the first time in the Sixth Edition. Due attention has been paid to new drugs being tested in North America and Europe that will probably be on the market soon.
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Product details

  • Hardback | 956 pages
  • 220 x 280 x 42mm | 2,313.35g
  • Oxford University Press Inc
  • New York, United States
  • English
  • Revised
  • 6th Revised edition
  • 1 halftone, 436 line drawings, bibliography
  • 0195100247
  • 9780195100242

Table of contents

I. GENERAL PRINCIPLES OF PHARMACOLOGY; 1. Introduction to General Pharmacology; 2. Drug Solubility, Absorption, and Movement Across Body Membranes; 3. Drug Distribution; 4. Drug Biotransformation; 5. Pharmacokinetics; 6. Clearance: The Quantitative Basis of Dosage; 7. Drug Clearance by Specific Organs; 8. Dose-Response Relationships; 9. Drug Receptors; 10. Signal Transduction and Second Messengers; 11. Selectivity of Drug Action; 12. Human Pharmacogenetics; II. AUTONOMIC NERVOUS SYSTEM AND NEUROMUSCULAR JUNCTION; 13. Autonomic Nervous System Neurotransmitters; 14. Autonomic Cholinergic Agonists; 15. Autonomic Cholinergic Antagonists; 16. Adrenoceptor Agonists; 17. Adrenoceptor Antagonists; 18. Drugs Acting on Adrenergic Neurons (Adrenergic Neuronal Blocking Drugs); 19. Neuromuscular Transmission and Drugs (Muscle Relaxants); III. CENTRAL NERVOUS SYSTEM; 20. Functional Organization of the Central Nervous System; 21. Agents Modifying Movement Control; 22. Antiseizure Drugs; 23. Opioid Analgesics and Antagonists; 24. General Anesthetics; 25. Local Anesthetics; 26. The Alcohols; 27. Anxiolytics and Hypnotics; 28. Antipsychotics; 29. Antidepressant and Mood Stabilizing Agents; 30. Hallucinogens and Psychotomimetics; IV. MEDIATORS AND MODIFIERS OF TISSUE RESPONSES; 31. The Eicosanoids; 32. Autacoids; 33. Histamine and Antihistamines; 34. Anti-Inflammatory Analgesics; V. CARDIOVASCULAR SYSTEM; 35. Cardiovascular System Overview and Organization; 36. Digitalis Glycosides and Other Positive Inotropic Agents; 37. Antiarrhythmic Drugs; 38. Vasodilators; 39. Hyperlipoproteinemias and Antihyperlipidemic Drugs; VI. RESPIRATORY, RENAL, AND BLOOD SYSTEMS; 40. Drugs and the Respiratory System; 41. Diuretics; 42. Drugs Affecting Hemostasis; 43. Drugs Affecting Erythropoiesis; VII. GASTROINTESTINAL SYSTEM; 44. Pharmacotherapy of Acid-Peptic Disorders; 45. Drugs Used in the Treatment of Intestinal Motility Disorders and Inflammatory Disease; 46. Drugs, Alcohol and the Liver; VIII. ENDOCRINE SYSTEMS; 47. Vasopressin, Oxytocin, and Uterotonic Drugs; 48. Thyroid Hormones and Antihyperthyroid Drugs; 49. Gonadotropic and Gonadal Hormones; 50. Insulin and Oral Hypoglycemic Drugs; 51. Adrenocortical Steroid Hormones; IX. ANTI-INFECTIVE CHEMOTHERAPY; 52. Principles of Antimicrobial Therapy; 53. Antimicrobial Agents That Act upon Bacterial Cell Wall Formation; 54. Antimicrobial and Antifungal Agents That Act upon Cell Membranes; 55. Antimicrobial Agents That Affect the Synthesis of Cellular Proteins; 56. Drugs Affecting Cellular Nucleic Acid Synthesis; 57. Chemotherapy of Common Parasitic Infections; 58. Antiviral Agents; 59. Antiseptics, Disinfectants, and Sterilization; X. ANTINEOPLASTIC CHEMOTHERAPY, IMMUNOPHARMACOLOGY; 60. Antineoplastic Drugs; 61. Immune System Organization, Modulation, and Pharmacology; XI. SPECIAL TOPICS OF PHARMACOLOGY; 62. Sources of Individual Variation in Drug Response; 63. Adverse Drug Reactions; 64. Drug Interactions; 65. Perinatal Pharmacology; 66. Geriatric Clinical Pharmacology; 67. Vitamins; 68. Drugs Altering Bone Metabolism; 69. Chemical Carcinogenesis; 70. Chemical Teratogenesis; 71. Behavioral Pharmacology; 72. Drug Abuse and Drug Dependence; 73. Principles of Toxicology; 74. Poisonings and Antidotal Therapy; 75. Drug Development and Regulations; INDEX
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About Harold Kalant

About the authors Harold Kalant, M.D., Ph.D., is Professor Emeritus in the Department of Pharmacology at the University of Toronto Faculty of Medicine. Walter H.E. Roschlau, M.D., is Professor Emeritus in the same department
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Review quote

Praise for previous editions: "An excellent textbook...The illustrations are simple and easy to comprehend."--James W. Fisher, Chairman, Department of Pharmacology, Tulane University"The authors and the editors have done a superlative job of writing and revision. I like the new format and printing style, and I am particularly impressed with the redrawn illustrations."--D.R.H. Gourley, Chairman, Department of Pharmacology, Eastern Virginia Medical School"An easily read, inclusive, well illustrated, well organized, and up-to-date introductory text....The figures are illustrative, well presented and informative. The tables are clear and accurate."--American Journal of Pharmaceutical Education"Many aspects of this book are noteworthy. The overall organization is coherent and logical....The quality of the writing is good...The text amply lives up to its commitment to provide 'mainly...solid basics'."--Canadian Medical Association Journal Praise for previous editions: "An excellent textbook...The illustrations are simple and easy to comprehend."--James W. Fisher, Chairman, Department of Pharmacology, Tulane University "The authors and the editors have done a superlative job of writing and revision. I like the new format and printing style, and I am particularly impressed with the redrawn illustrations."--D.R.H. Gourley, Chairman, Department of Pharmacology, Eastern Virginia Medical School "An easily read, inclusive, well illustrated, well organized, and up-to-date introductory text....The figures are illustrative, well presented and informative. The tables are clear and accurate."--American Journal of Pharmaceutical Education "Many aspects of this book are noteworthy. The overall organization is coherent and logical....The quality of the writing is good...The text amply lives up to its commitment to provide 'mainly...solid basics'."--Canadian Medical Association Journal Praise for previous editions: "An excellent textbook...The illustrations are simple and easy to comprehend."--James W. Fisher, Chairman, Department of Pharmacology, Tulane University"The authors and the editors have done a superlative job of writing and revision. I like the new format and printing style, and I am particularly impressed with the redrawn illustrations."--D.R.H. Gourley, Chairman, Department of Pharmacology, Eastern Virginia Medical School"An easily read, inclusive, well illustrated, well organized, and up-to-date introductory text....The figures are illustrative, well presented and informative. The tables are clear and accurate."--American Journal of Pharmaceutical Education"Many aspects of this book are noteworthy. The overall organization is coherent and logical....The quality of the writing is good...The text amply lives up to its commitment to provide 'mainly...solid basics'."--Canadian Medical Association Journal Praise for previous editions: "An excellent textbook...The illustrations are simple and easy to comprehend."--James W. Fisher, Chairman, Department of Pharmacology, Tulane University "The authors and the editors have done a superlative job of writing and revision. I like the new format and printing style, and I am particularly impressed with the redrawn illustrations."--D.R.H. Gourley, Chairman, Department of Pharmacology, Eastern Virginia Medical School "An easily read, inclusive, well illustrated, well organized, and up-to-date introductory text....The figures are illustrative, well presented and informative. The tables are clear and accurate."--American Journal of Pharmaceutical Education "Many aspects of this book are noteworthy. The overall organization is coherent and logical....The quality of the writing is good...The text amply lives up to its commitment to provide 'mainly...solid basics'."--Canadian Medical Association Journal Praise for previous editions: "An excellent textbook...The illustrations are simple and easy to comprehend."--James W. Fisher, Chairman, Department of Pharmacology, Tulane University"The authors and the editors have done a superlative job of writing and revision. I like the new format and printing style, and I am particularly impressed with the redrawn illustrations."--D.R.H. Gourley, Chairman, Department of Pharmacology, Eastern Virginia Medical School"An easily read, inclusive, well illustrated, well organized, and up-to-date introductory text....The figures are illustrative, well presented and informative. The tables are clear and accurate."--American Journal of Pharmaceutical Education"Many aspects of this book are noteworthy. The overall organization is coherent and logical....The quality of the writing is good...The text amply lives up to its commitment to provide 'mainly...solid basics'."--Canadian Medical Association Journal
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